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公开(公告)号：US20240141288A1
公开(公告)日：2024-05-02
申请号：US17993659
申请日：2022-11-23
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M.R. Ferreira , Jack L. Strominger , Chad A. Cowan
IPC: C12N5/0735 , A61K39/00 , C12N5/074 , C12N15/86 , C12N15/90
CPC classification number: C12N5/0606 , A61K39/001 , C12N5/0696 , C12N15/86 , C12N15/907 , C12N2310/20 , C12N2501/50 , C12N2501/599 , C12N2501/998 , C12N2510/00
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US12031154B2
公开(公告)日：2024-07-09
申请号：US17993674
申请日：2022-11-23
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M. R. Ferreira , Jack L. Strominger , Chad A Cowan
IPC: C12N5/0735 , A61K39/00 , C12N5/074 , C12N15/86 , C12N15/90
CPC classification number: C12N5/0606 , A61K39/001 , C12N5/0696 , C12N15/86 , C12N15/907 , C12N2310/20 , C12N2501/50 , C12N2501/599 , C12N2501/998 , C12N2510/00
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US20230303969A1
公开(公告)日：2023-09-28
申请号：US17993680
申请日：2022-11-23
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M.R. Ferreira , Jack L. Strominger , Chad A. Cowan
IPC: C12N5/0735 , C12N5/074 , C12N15/86 , C12N15/90 , A61K39/00
CPC classification number: C12N5/0606 , C12N5/0696 , C12N15/86 , C12N15/907 , A61K39/001 , C12N2310/20 , C12N2501/599 , C12N2501/998 , C12N2510/00 , C12N2501/50
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US20210261916A1
公开(公告)日：2021-08-26
申请号：US17148556
申请日：2021-01-13
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M.R. Ferreira , Jack L. Strominger , Chad A. Cowan
IPC: C12N5/0735 , C12N5/074 , C12N15/86 , C12N15/90 , A61K39/00
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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5.发明申请公开(公告)号：US20180141992A1
公开(公告)日：2018-05-24
申请号：US15524968
申请日：2015-11-06
Applicant: President and Fellows of Harvard College
Inventor： Chad A. Cowan , Leonardo M.R. Ferreira , Torsten B. Meissner , Jack L. Strominger
CPC classification number: C07K14/70539 , A61K35/12 , A61K35/28 , A61K48/0066 , A61K2035/124 , A61P31/18 , C12N5/0647 , C12N9/22 , C12N15/11 , C12N15/1138 , C12N2310/10 , C12N2310/20 , C12N2510/00
Abstract: Disclosed herein are cells and populations of cells comprising a genome in which the B2M gene has been edited to eliminate surface expression of MHC Class I protein in the cells or population of cells, and methods for allogeneic administration of such cells to reduce the likelihood that the cells will trigger a host immune response when the cells are administered to a subject in need of such cells.
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Patent Agency Ranking
公开(公告)号：US20230303968A1
公开(公告)日：2023-09-28
申请号：US17993674
申请日：2022-11-23
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M.R. Ferreira , Jack L. Strominger , Chad A. Cowan
IPC: C12N5/0735 , C12N5/074 , C12N15/86 , C12N15/90 , A61K39/00
CPC classification number: C12N5/0606 , C12N5/0696 , C12N15/86 , C12N15/907 , A61K39/001 , C12N2310/20 , C12N2501/599 , C12N2501/998 , C12N2510/00 , C12N2501/50
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US10968426B2
公开(公告)日：2021-04-06
申请号：US15572776
申请日：2016-05-09
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M. R. Ferreira , Jack L. Strominger , Chad A. Cowan
IPC: C12N5/0735 , C12N5/074 , C12N15/86 , C12N15/90 , A61K39/00
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US20240368539A1
公开(公告)日：2024-11-07
申请号：US18658343
申请日：2024-05-08
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M.R. Ferreira , Jack L. Strominger , Chad A. Cowan
IPC: C12N5/0735 , A61K39/00 , C12N5/074 , C12N15/86 , C12N15/90
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US12110500B2
公开(公告)日：2024-10-08
申请号：US17993667
申请日：2022-11-23
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M. R. Ferreira , Jack L. Strominger , Chad A. Cowan
IPC: C12N5/0735 , A61K39/00 , C12N5/074 , C12N15/86 , C12N15/90
CPC classification number: C12N5/0606 , A61K39/001 , C12N5/0696 , C12N15/86 , C12N15/907 , C12N2310/20 , C12N2501/50 , C12N2501/599 , C12N2501/998 , C12N2510/00
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US12031155B2
公开(公告)日：2024-07-09
申请号：US17993680
申请日：2022-11-23
Applicant: President and Fellows of Harvard College
Inventor： Torsten B. Meissner , Leonardo M. R. Ferreira , Jack L. Strominger , Chad A. Cowan
IPC: C12N5/0735 , A61K39/00 , C12N5/074 , C12N15/86 , C12N15/90
CPC classification number: C12N5/0606 , A61K39/001 , C12N5/0696 , C12N15/86 , C12N15/907 , C12N2310/20 , C12N2501/50 , C12N2501/599 , C12N2501/998 , C12N2510/00
Abstract: Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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