公开(公告)号：US20160002300A1

公开(公告)日：2016-01-07

申请号：US14766359

申请日：2014-02-05

Applicant: Chi-Ming LIANG ,  Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  C12N7/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/292 ,  C12N7/00 ,  C12N2730/10133 ,  C12N2730/10134

Abstract: A pharmaceutical composition for use in killing and/or inhibiting the growth and/or proliferation of a microorganism in a subject in need thereof, or for treating a subject afflicted with a microbial infection is disclosed. The composition comprises: (a) an effective amount of an isolated peptide, wherein the peptide comprises the arginine-rich carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an antimicrobial activity; and (b) a pharmaceutically acceptable carrier. The peptide exhibits an activity against Gram-negative bacteria, Gram-positive bacteria, and/or fungi.

Abstract translation: 公开了用于杀死和/或抑制有需要的受试者中的微生物的生长和/或增殖或用于治疗受到微生物感染的受试者的药物组合物。 所述组合物包含：（a）有效量的分离的肽，其中所述肽包含乙型肝炎病毒核心蛋白（HBc）的富含精氨酸的羧基末端区域并显示出抗微生物活性; 和（b）药学上可接受的载体。 肽表现出对革兰氏阴性菌，革兰氏阳性菌和/或真菌的活性。

公开(公告)号：US20190144510A1

公开(公告)日：2019-05-16

申请号：US16303464

申请日：2017-05-25

Applicant: Chiaho Shih ,  Academia Sinica Office Of Public Affairs (Technology Transfer)(05)

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  A61P31/04

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：US10752657B2

公开(公告)日：2020-08-25

申请号：US16258115

申请日：2019-01-25

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/29 ,  C12N7/00 ,  A61K38/00

Abstract: A pharmaceutical composition comprising: (a) an isolated peptide, wherein the peptide includes three or four arginine-rich domains (ARDs) from the carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an anti-microbial activity; and (b) a pharmaceutically acceptable carrier.

公开(公告)号：US12084479B2

公开(公告)日：2024-09-10

申请号：US16932372

申请日：2020-07-17

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  A01N37/46 ,  A01N63/50 ,  A61K38/00 ,  A61P31/04 ,  C07K7/08

CPC classification number: C07K14/005 ,  A01N37/46 ,  A01N63/50 ,  A61P31/04 ,  C07K7/08 ,  A61K38/00 ,  C12N2730/10122 ,  C12N2730/10133

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：US20210101939A1

公开(公告)日：2021-04-08

申请号：US16932372

申请日：2020-07-17

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  A01N37/46 ,  A01N63/00 ,  C07K7/08 ,  A61P31/04

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：US20190153042A1

公开(公告)日：2019-05-23

申请号：US16258115

申请日：2019-01-25

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  A61K39/29 ,  C12N7/00 ,  A61K39/12

Abstract: A pharmaceutical composition comprising: (a) an isolated peptide, wherein the peptide includes three or four arginine-rich domains (ARDs) from the carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an anti-microbial activity; and (b) a pharmaceutically acceptable carrier.

公开(公告)号：US10214564B2

公开(公告)日：2019-02-26

申请号：US14766359

申请日：2014-02-05

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  C12N7/00 ,  A61K39/29 ,  A61K39/12 ,  A61K38/00

Abstract: A pharmaceutical composition for use in killing and/or inhibiting the growth and/or proliferation of a microorganism in a subject in need thereof, or for treating a subject afflicted with a microbial infection is disclosed. The composition comprises: (a) an effective amount of an isolated peptide, wherein the peptide comprises the arginine-rich carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an antimicrobial activity; and (b) a pharmaceutically acceptable carrier. The peptide exhibits an activity against Gram-negative bacteria, Gram-positive bacteria, and/or fungi.