公开(公告)号：US20240232289A9

公开(公告)日：2024-07-11

申请号：US17969507

申请日：2022-10-19

申请人： Wallac Oy

发明人： Aki Koivu ,  Kim Karlin ,  Petri Kivelä ,  Markku Jaakkola

IPC分类号： G06F17/18 ,  H04N5/60

CPC分类号： G06F17/18 ,  H04N5/60

摘要： A method for applying pairwise differential privacy to variables in a data set is disclosed. The method includes designating a random instance seed value to a first data set variable in an original data set and designating the random instance seed value to at least one additional data set variable in the original data set if a high degree of correlation is identified between the first data set variable and the at least one additional data set variable. The method further includes determining an adaptive sensitivity parameter corresponding to the first data set variable and utilizing, by a noise generation manager, two or more among the first data set variable, the random instance seed value, and/or the adaptive sensitivity parameter to generate and apply additive noise to the first data set variable to produce a pseudonymized variable for inclusion in a pseudonymized data set associated with the original data set.

公开(公告)号：US10444247B2

公开(公告)日：2019-10-15

申请号：US15512190

申请日：2015-09-11

申请人： Wallac Oy

发明人： Pertti Hurskainen ,  Heikki Kouru ,  Mikko Sairanen ,  Tarja Ahola ,  Teemu Korpimäki

IPC分类号： G01N33/68 ,  G01N33/53

摘要： The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.

公开(公告)号：US09736555B2

公开(公告)日：2017-08-15

申请号：US14784768

申请日：2014-04-08

申请人： WALLAC OY

发明人： Ville Petteri Laitala ,  Raimo Harju

IPC分类号： H04Q11/00 ,  C12Q1/68 ,  G01N21/27 ,  G01N21/64

CPC分类号： H04Q11/0005 ,  C12Q1/6818 ,  C12Q2537/101 ,  G01N21/274 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2021/6441 ,  H04Q11/0003 ,  H04Q2011/0049

摘要： A method for cross-talk correction of intensities measured on mutually separate detection wavelength bands is presented. Each detection wavelength band relates to one of analyte-specific probe-populations contained by a sample to be analyzed. Each probe-population is capable of emitting a first signal component and a second signal component whose spectra have maxima at different wavelengths and at least the first signal component is dependent on presence of analyte detectable with that probe-population. Cross-talk corrected intensities are computed on the basis of a) the intensities measured on the detection wavelength bands, b) a value indicative of intensity occurring on an auxiliary wavelength band outside the detection wavelength bands and at least partially caused by the second signal components, and c) pre-determined cross-talk parameters. For example in con-junction with FRET-based assays, the dependency of a background signal on the percentage of hybridized probes can be taken into account in the cross-talk correction.

公开(公告)号：US20140273025A1

公开(公告)日：2014-09-18

申请号：US13837134

申请日：2013-03-15

申请人： WALLAC OY

发明人： Pertti Hurskainen ,  Teemu Korpimäki ,  Heikki Kouru ,  Mikko Sairanen

IPC分类号： G01N33/68

CPC分类号： G01N33/689 ,  G01N2333/47 ,  G01N2333/475 ,  G01N2333/515 ,  G01N2800/368 ,  G01N2800/50 ,  G16B40/00

摘要： A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.

摘要翻译： 用于预测怀孕个体中先兆子痫风险的方法包括在从怀孕个体获得的血液样品中测量一种或多种生物化学标志物，包括RBP4生物化学标记物，以确定一种或多种生物标志物水平，包括RBP4生物标志物水平，鉴定 所述一个或多个测量的生物化学标记中的每一个，所测量的生物标志物水平与相应的预定对照水平之间的差异，以及响应于所述鉴定，确定对应于具有或发展先兆子痫的孕妇的相对风险的预测。

公开(公告)号：US08814427B2

公开(公告)日：2014-08-26

申请号：US13146290

申请日：2009-10-13

申请人： Jyrki Laitinen ,  Markku Ojala

发明人： Jyrki Laitinen ,  Markku Ojala

IPC分类号： G01N25/20 ,  G01J5/08 ,  G01N21/25 ,  G01N21/64

CPC分类号： G01N21/253 ,  G01N21/6452 ,  G01N2201/1211

摘要： An optical measurement instrument includes one or more temperature sensors (122) arranged to measure sample well specific temperatures from sample wells (111-117) arranged to store samples (103-109) to be optically measured. A processing device (121) of the optical measurement instrument is arranged to correct, using a pre-determined mathematical rule, measurement results obtained by the optical measurements on the basis of the measured sample well specific temperatures. Hence, the adverse effect caused by temperature differences between different samples on the accuracy of the temperature correction of the measurement results is mitigated.

摘要翻译： 一种光学测量仪器包括一个或多个温度传感器（122），其设置成测量样品阱特定的温度，该样品井被布置成存储待光学测量的样品（103-109）的样品孔（111-117）。 光学测量仪器的处理设备（121）被布置成使用预定的数学规则来校正通过基于测量的样品阱特定温度的光学测量获得的测量结果。 因此，不同样品之间的温度差异对测量结果的温度校正精度的不利影响得到了缓解。

公开(公告)号：US08742367B2

公开(公告)日：2014-06-03

申请号：US12739144

申请日：2008-10-08

申请人： Jyrki Laitinen ,  Petri Kivelä

发明人： Jyrki Laitinen ,  Petri Kivelä

IPC分类号： G01N21/64 ,  G01J3/10 ,  G01J3/44 ,  G01N21/25 ,  G01J3/42 ,  G01J3/12 ,  G02B6/42 ,  G01J3/02

CPC分类号： G01N21/253 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/12 ,  G01J3/42 ,  G01J3/44 ,  G01N21/6408 ,  G01N21/6452 ,  G01N2021/6439 ,  G01N2021/6484 ,  G01N2021/6491 ,  G02B6/4298

摘要： An apparatus for optically analyzing samples contained in sample sites of a sample holder, the apparatus has a first light source and at least one second light source, a monochromator having an input to which first light source is optically connected or connectable and an output for monochromatized light, light guiding portion for guiding light originating from the first and from the at least one second light sources to the sample sites, and a detector for detecting light from the sample sites. A light relay having a first input optically connected to the output of the monochromator, at least one second input optically connected or connectable to a second light source such that the light from the second light source by-passes the monochromator, and a first output for guiding light from selected input of the light relay to the sample sites. Based on the apparatus and light relay a versatile sample analyzer can be achieved in a cost-effective manner.

摘要翻译： 一种用于光学分析样品保持器的样品位置中包含的样品的装置，该装置具有第一光源和至少一个第二光源，具有第一光源被光学连接或可连接的输入的单色仪和用于单色化的输出 用于引导来自第一和至少一个第二光源的光源到样品位置的光，光引导部分，以及用于检测来自样品位点的光的检测器。 一种光继电器，具有光学连接到单色仪的输出的第一输入，至少一个第二输入，光学连接或可连接到第二光源，使得来自第二光源的光旁路单色器，以及第一输出， 将光继电器的选定输入的光引导到样品位置。 基于设备和光继电器，可以以成本有效的方式实现通用的样品分析仪。

公开(公告)号：US08597903B2

公开(公告)日：2013-12-03

申请号：US13256819

申请日：2010-03-10

申请人： Jarkko Karvinen ,  Pertti Hurskainen ,  Pekka Mattsson ,  Outi Mulari ,  Jari Peuralahti ,  Lassi Jaakkola

发明人： Jarkko Karvinen ,  Pertti Hurskainen ,  Pekka Mattsson ,  Outi Mulari ,  Jari Peuralahti ,  Lassi Jaakkola

IPC分类号： C12Q1/34 ,  C07D403/02 ,  C07D235/00 ,  C07F15/00

CPC分类号： C12Q1/37 ,  G01N2333/98

摘要： The present technology discloses biotinidase assay, biotinidase substrates (I) and a kit wherein the biotinidase substrate includes a label molecule separated from the biotin carbamoyl group by a linker X longer than about 4 Å but shorter than about 27 Å.

摘要翻译： 本技术公开了生物素酶测定，生物素酶底物（I）和试剂盒，其中生物素酶底物包括通过长度大于约但小于约的连接体X从生物素氨基甲酰基分离的标记分子。

公开(公告)号：US20120135427A1

公开(公告)日：2012-05-31

申请号：US13259883

申请日：2010-04-23

申请人： Nicolaides Kypros ,  Tarja Ahola

发明人： Nicolaides Kypros ,  Tarja Ahola

IPC分类号： G01N33/566

CPC分类号： G01N33/74 ,  G01N2333/475 ,  G01N2800/368

摘要： The present description relates to a method for determining the risk of a pregnant woman developing a hypertensive disorder, more specifically gestational hyper-tension or late onset preeclampsia. The present description provides methods useful for determining risk that a pregnant individual will develop a hypertensive disorder or condition of pregnancy, such as gestational hypertension, early preeclampsia, late preeclampsia and related disorders. Several useful combinations of biochemical markers and related clinical population studies are described herein. Additionally, it is proposed herein that certain sets of biochemical markers can be used to determine risk of multiple hypertensive disorders in a single screen. The biochemical markers are PlGF, Activin A and optionally P-Selectin.

摘要翻译： 本描述涉及一种用于确定孕妇发展为高血压病症，特别是妊娠期高血压或迟发性先兆子痫的风险的方法。 本描述提供了用于确定怀孕个体将发展为高血压病症或妊娠状况（诸如妊娠高血压，早期先兆子痫，晚期先兆子痫和相关疾病）的风险的方法。 本文描述了生化标记物和相关临床群体研究的几种有用组合。 此外，在本文中提出，可以使用某些组生化标志物来确定单个筛选中的多种高血压疾病的风险。 生化标志物是PlGF，活化素A和任选的P-选择素。

公开(公告)号：US08158782B2

公开(公告)日：2012-04-17

申请号：US12298143

申请日：2007-05-04

申请人： Jari Hovinen

发明人： Jari Hovinen

IPC分类号： C07D255/02 ,  C07D257/02

CPC分类号： C07D255/02 ,  C07D257/02 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07F9/6515 ,  C07F9/65586 ,  C07K1/13

摘要： This invention concerns novel labeling reactants based on azacycloalkanes, wherein a suitable group is linked to the molecule allowing introduction of the said molecules to bioactive molecules in solution or on solid phase.

摘要翻译： 本发明涉及基于氮杂环烷烃的新型标记反应物，其中合适的基团与分子连接，允许将所述分子引入溶液或固相中的生物活性分子。

公开(公告)号：US20110070585A1

公开(公告)日：2011-03-24

申请号：US12832647

申请日：2010-07-08

申请人： Pia OLLIKKA ,  Alice Ylikoski

发明人： Pia OLLIKKA ,  Alice Ylikoski

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  C12Q2523/308

摘要： The present invention relates to an integrated method of nucleic acid analysis, and more particularly to a simplified sample pre-treatment, which renders the method more easily automated, where the sample is provided on or applied onto a solid matrix and the subsequent amplification and detection steps are performed in one single, sealed reaction vial without removing the matrix.

摘要翻译： 本发明涉及一种综合的核酸分析方法，更具体地说涉及简化的样品预处理，其使得该方法更容易自动化，其中将样品提供在固体基质上或施加到固体基质上，随后的扩增和检测 在一个单一密封的反应小瓶中进行步骤，而不去除基质。