公开(公告)号：US20120135427A1

公开(公告)日：2012-05-31

申请号：US13259883

申请日：2010-04-23

申请人： Nicolaides Kypros ,  Tarja Ahola

发明人： Nicolaides Kypros ,  Tarja Ahola

IPC分类号： G01N33/566

CPC分类号： G01N33/74 ,  G01N2333/475 ,  G01N2800/368

摘要： The present description relates to a method for determining the risk of a pregnant woman developing a hypertensive disorder, more specifically gestational hyper-tension or late onset preeclampsia. The present description provides methods useful for determining risk that a pregnant individual will develop a hypertensive disorder or condition of pregnancy, such as gestational hypertension, early preeclampsia, late preeclampsia and related disorders. Several useful combinations of biochemical markers and related clinical population studies are described herein. Additionally, it is proposed herein that certain sets of biochemical markers can be used to determine risk of multiple hypertensive disorders in a single screen. The biochemical markers are PlGF, Activin A and optionally P-Selectin.

摘要翻译： 本描述涉及一种用于确定孕妇发展为高血压病症，特别是妊娠期高血压或迟发性先兆子痫的风险的方法。 本描述提供了用于确定怀孕个体将发展为高血压病症或妊娠状况（诸如妊娠高血压，早期先兆子痫，晚期先兆子痫和相关疾病）的风险的方法。 本文描述了生化标记物和相关临床群体研究的几种有用组合。 此外，在本文中提出，可以使用某些组生化标志物来确定单个筛选中的多种高血压疾病的风险。 生化标志物是PlGF，活化素A和任选的P-选择素。