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公开(公告)号：US20230355626A1
公开(公告)日：2023-11-09
申请号：US17802194
申请日：2021-03-03
发明人： Eric P. GILLIS , Christiana IWUAGWU
IPC分类号： A61K31/519 , C07D471/04 , A61K31/5365 , A61K31/537 , A61K31/513 , A61K31/675 , A61K31/4985 , A61K31/54 , A61K45/06 , A61P31/18
CPC分类号： A61K31/519 , C07D471/04 , A61K31/5365 , A61K31/537 , A61K31/513 , A61K31/675 , A61K31/4985 , A61K31/54 , A61K45/06 , A61P31/18
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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公开(公告)号：US11084845B2
公开(公告)日：2021-08-10
申请号：US16534208
申请日：2019-08-07
发明人： Jie Chen , Yan Chen , Ira B. Dicker , Richard A. Hartz , Nicholas A. Meanwell , Beata Nowicka-Sans , Alicia Regueiro-Ren , Sing-Yuen Sit , Ny Sin , Jacob Swidorski , Brian Lee Venables
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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3.发明申请公开(公告)号：US20210024503A1
公开(公告)日：2021-01-28
申请号：US17042413
申请日：2019-04-11
发明人： Makonen BELEMA , John A. BENDER , David B. FRENNESSON , Eric P. GILLIS , Christiana IWUAGWU , John F. KADOW , B. Narasimhulu NAIDU , Kyle E. PARCELLA , Kevin M. PEESE , Ramkumar RAJAMANI , Mark G. SAULNIER , Alan Xiangdong WANG , Manoj PATEL , Michael S. BOWSHER
IPC分类号： C07D403/14 , A61P31/18 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D491/052
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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公开(公告)号：US10407490B2
公开(公告)日：2019-09-10
申请号：US15568830
申请日：2016-04-14
发明人： Mark R. Krystal , David L. Wensel , Jonathan Davis
IPC分类号： A61K38/00 , A61P31/18 , C07K14/78 , A61K47/60 , C07K14/79 , C07K14/005 , C07K14/765
摘要： The invention is directed to polypeptides comprising a CD4 binding moiety, a gp41 binding moiety, a HIV fusion peptide inhibitor moiety and combinations thereof. More specifically, the present invention relates to polypeptides comprising a fibronectin-based scaffold domain protein that binds CD4, a fibronectin-based scaffold domain protein that binds the N17 domain of gp41, and a HIV fusion peptide inhibitor or combinations thereof. The invention also relates to the use of the innovative proteins in therapeutic applications to treat HIV.
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5.发明授权公开(公告)号：US10351546B2
公开(公告)日：2019-07-16
申请号：US15749584
申请日：2016-08-10
发明人： Kyle J. Eastman , John F. Kadow , B. Narasimhulu Naidu , Kyle E. Parcella , Manoj Patel , Prasanna Sivaprakasam , Yong Tu
IPC分类号： A61K31/444 , C07D401/14 , C07D405/14 , C07D401/04 , C07D487/04 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV.
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6.发明授权公开(公告)号：US10221156B2
公开(公告)日：2019-03-05
申请号：US15579977
申请日：2016-07-06
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61P31/18
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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7.发明授权公开(公告)号：US10106504B2
公开(公告)日：2018-10-23
申请号：US15749133
申请日：2016-08-18
发明人： John F. Kadow , B. Narasimhulu Naidu , Yong Tu
IPC分类号： C07D213/55 , C07D405/14 , C07D405/04 , C07D487/04 , C07D491/052 , A61K31/5365 , A61K31/4433 , A61K31/4418 , A61P31/18 , A61K31/519 , A61K31/506 , C07D401/04 , C07D491/06 , A61K31/4741 , A61K31/4725
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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公开(公告)号：US09932356B2
公开(公告)日：2018-04-03
申请号：US15115758
申请日：2015-02-10
IPC分类号： C07D513/22 , C07D498/22 , C07D471/22
CPC分类号： C07D513/22 , C07D471/22 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US09834566B2
公开(公告)日：2017-12-05
申请号：US15119431
申请日：2015-02-13
发明人： John F. Kadow , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D498/16 , C07D498/22 , A61K31/519 , A61K45/06
CPC分类号： C07D498/16 , A61K31/519 , A61K45/06 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US20170305962A1
公开(公告)日：2017-10-26
申请号：US15523453
申请日：2015-11-12
发明人： Jie CHEN , Yan CHEN , Nicholas A. MEANWELL , Alicia REGUEIRO-REN , NY SIN , Sing-Yuen SIT
IPC分类号： C07J63/00
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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