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公开(公告)号：US20230192758A1
公开(公告)日：2023-06-22
申请号：US18096272
申请日：2023-01-12
IPC分类号： C07J63/00 , A61P31/18 , A61K31/4985 , A61K31/5365 , A61K31/58
CPC分类号： C07J63/008 , A61P31/18 , A61K31/4985 , A61K31/5365 , A61K31/58
摘要： The present invention relates to compound of Formula I or a pharmaceutically acceptable salt thereof
wherein R1 is
where the squiggly line indicates the point of attachment to the rest of the molecule;
R2 is F or
where the squiggly line indicates the point of attachment to the rest of the molecule;
R3 is H or CH3;
Z is O or is absent; and
R4 is —OC1-3alkyl, C1-30alkyl, or —N(CH3)2.-
2.发明授权公开(公告)号：US11505543B2
公开(公告)日：2022-11-22
申请号：US17042413
申请日：2019-04-11
发明人： Makonen Belema , John A. Bender , David B. Frennesson , Eric P. Gillis , Christiana Iwuagwu , John F. Kadow , B. Narasimhulu Naidu , Kyle E. Parcella , Kevin M. Peese , Ramkumar Rajamani , Mark G. Saulnier , Alan Xiangdong Wang , Manoj Patel , Michael S. Bowsher
IPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , A61K31/517 , A61P31/18 , C07D403/12 , C07D413/14 , C07D491/052
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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![5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication](/abs-image/US/2020/03/03/US10577353B2/abs.jpg.150x150.jpg)
公开(公告)号：US10577353B2
公开(公告)日：2020-03-03
申请号：US15749144
申请日：2016-08-10
发明人： John F. Kadow , B. Narasimhulu Naidu , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D401/14 , C07D403/14 , C07D473/16 , C07D471/04 , C07D513/04 , C07D487/04 , C07D495/04 , C07D417/14 , C07D473/18 , A61K31/4427 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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4.发明授权公开(公告)号：US10407410B2
公开(公告)日：2019-09-10
申请号：US16094536
申请日：2017-05-09
发明人： John F. Kadow , B. Narasimhulu Naidu , Manoj Patel , Michael A. Walker , Tao Wang , Zhiwei Yin , Zhongxing Zhang , Zhizhen Barbara Zheng
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D407/14 , C07D409/14 , C07D417/14 , A61P31/18 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5365 , C07D411/14
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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公开(公告)号：US10125148B2
公开(公告)日：2018-11-13
申请号：US15119475
申请日：2014-02-19
发明人： Timothy P. Connolly , Stanley D'Andrea , John F. Kadow , David R. Langley , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Michael A. Walker , Zhongyu Wang , Zhizhen Barbara Zheng
IPC分类号： C07D498/16 , C07D498/22 , A61K31/519 , A61K45/06
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US09938271B2
公开(公告)日：2018-04-10
申请号：US15119465
申请日：2015-02-13
IPC分类号： C07D471/04 , C07D498/22
CPC分类号： C07D471/04 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US09540393B2
公开(公告)日：2017-01-10
申请号：US14773028
申请日：2014-03-07
IPC分类号： A61K31/535 , C07D498/22 , A61K31/519 , A61K31/5383 , C07D487/04 , C07D487/16 , C07D498/16 , A61K45/06 , A61K31/529 , A61K31/5386 , C07D471/22 , C07D498/18
CPC分类号： C07D498/22 , A61K31/519 , A61K31/529 , A61K31/5383 , A61K31/5386 , A61K45/06 , C07D471/22 , C07D487/04 , C07D487/16 , C07D498/16 , C07D498/18 , A61K2300/00
摘要： The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
摘要翻译： 本发明一般涉及式（I）化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
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公开(公告)号：US10954252B1
公开(公告)日：2021-03-23
申请号：US16606345
申请日：2018-05-01
发明人： Suresh Babu , Makonen Belema , John A. Bender , Christiana Iwuagwu , John F. Kadow , Selvakumar Kumaravel , Pulicharla Nagalakshmi , B. Narasimhulu Naidu , Manoj Patel , Kevin M. Peese , Ramkumar Rajamani , Mark Saulnier , Alan Xiangdong Wang
IPC分类号： C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D513/04 , A61P31/18 , A61K45/06
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth.
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公开(公告)号：US09663536B2
公开(公告)日：2017-05-30
申请号：US14769646
申请日：2014-03-10
发明人： B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Zhongyu Wang
IPC分类号： C07D498/22 , A61K31/529 , C07D487/04 , C07D498/18 , C07D513/22 , C07D515/22 , A61K45/06
CPC分类号： C07D498/22 , A61K31/529 , A61K45/06 , C07D487/04 , C07D498/18 , C07D513/22 , C07D515/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection. Formule (I).
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10.发明授权公开(公告)号：US10351546B2
公开(公告)日：2019-07-16
申请号：US15749584
申请日：2016-08-10
发明人： Kyle J. Eastman , John F. Kadow , B. Narasimhulu Naidu , Kyle E. Parcella , Manoj Patel , Prasanna Sivaprakasam , Yong Tu
IPC分类号： A61K31/444 , C07D401/14 , C07D405/14 , C07D401/04 , C07D487/04 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV.
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