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1.发明授权公开(公告)号：US11505543B2
公开(公告)日：2022-11-22
申请号：US17042413
申请日：2019-04-11
发明人： Makonen Belema , John A. Bender , David B. Frennesson , Eric P. Gillis , Christiana Iwuagwu , John F. Kadow , B. Narasimhulu Naidu , Kyle E. Parcella , Kevin M. Peese , Ramkumar Rajamani , Mark G. Saulnier , Alan Xiangdong Wang , Manoj Patel , Michael S. Bowsher
IPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , A61K31/517 , A61P31/18 , C07D403/12 , C07D413/14 , C07D491/052
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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![5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication](/abs-image/US/2020/03/03/US10577353B2/abs.jpg.150x150.jpg)
公开(公告)号：US10577353B2
公开(公告)日：2020-03-03
申请号：US15749144
申请日：2016-08-10
发明人： John F. Kadow , B. Narasimhulu Naidu , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D401/14 , C07D403/14 , C07D473/16 , C07D471/04 , C07D513/04 , C07D487/04 , C07D495/04 , C07D417/14 , C07D473/18 , A61K31/4427 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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3.发明授权公开(公告)号：US10407410B2
公开(公告)日：2019-09-10
申请号：US16094536
申请日：2017-05-09
发明人： John F. Kadow , B. Narasimhulu Naidu , Manoj Patel , Michael A. Walker , Tao Wang , Zhiwei Yin , Zhongxing Zhang , Zhizhen Barbara Zheng
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D407/14 , C07D409/14 , C07D417/14 , A61P31/18 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5365 , C07D411/14
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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公开(公告)号：US10125148B2
公开(公告)日：2018-11-13
申请号：US15119475
申请日：2014-02-19
发明人： Timothy P. Connolly , Stanley D'Andrea , John F. Kadow , David R. Langley , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Michael A. Walker , Zhongyu Wang , Zhizhen Barbara Zheng
IPC分类号： C07D498/16 , C07D498/22 , A61K31/519 , A61K45/06
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US09938271B2
公开(公告)日：2018-04-10
申请号：US15119465
申请日：2015-02-13
IPC分类号： C07D471/04 , C07D498/22
CPC分类号： C07D471/04 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US09586957B2
公开(公告)日：2017-03-07
申请号：US14779648
申请日：2014-03-25
发明人： Tao Wang , Zhiwei Yin , Zhongxing Zhang , John A. Bender , Barry L. Johnson , John F. Kadow , Nicholas A. Meanwell
IPC分类号： A61K31/55 , C07D471/04 , A61K45/06 , A61K31/437 , C07D401/06 , A61K31/4545 , A61K31/454 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/55 , A61K45/06 , C07D401/06 , C07D519/00
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof: I useful as HIV attachment inhibitors.
摘要翻译： 式I的化合物，包括其药学上可接受的盐：可用作HIV附着抑制剂。
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7.发明授权公开(公告)号：US10351546B2
公开(公告)日：2019-07-16
申请号：US15749584
申请日：2016-08-10
发明人： Kyle J. Eastman , John F. Kadow , B. Narasimhulu Naidu , Kyle E. Parcella , Manoj Patel , Prasanna Sivaprakasam , Yong Tu
IPC分类号： A61K31/444 , C07D401/14 , C07D405/14 , C07D401/04 , C07D487/04 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV.
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公开(公告)号：US20190092754A1
公开(公告)日：2019-03-28
申请号：US16202653
申请日：2018-11-28
发明人： Kyle J. EASTMAN , John F. Kadow , Kyle E. Parcella , B. Narasimhulu Naidu , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D401/14 , C07D401/04 , A61K31/444 , A61P31/18
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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9.发明授权公开(公告)号：US10221156B2
公开(公告)日：2019-03-05
申请号：US15579977
申请日：2016-07-06
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61P31/18
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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10.发明授权公开(公告)号：US10106504B2
公开(公告)日：2018-10-23
申请号：US15749133
申请日：2016-08-18
发明人： John F. Kadow , B. Narasimhulu Naidu , Yong Tu
IPC分类号： C07D213/55 , C07D405/14 , C07D405/04 , C07D487/04 , C07D491/052 , A61K31/5365 , A61K31/4433 , A61K31/4418 , A61P31/18 , A61K31/519 , A61K31/506 , C07D401/04 , C07D491/06 , A61K31/4741 , A61K31/4725
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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