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公开(公告)号：US20190002534A1
公开(公告)日：2019-01-03
申请号：US15750716
申请日：2016-08-12
发明人： William D. THOMAS, Jr. , Yang WANG
IPC分类号： C07K16/10 , A61P31/14 , A61K39/205
CPC分类号： C07K16/10 , A61K39/12 , A61K39/205 , A61K2039/507 , A61K2300/00 , A61P31/14 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N2760/20121 , C12N2760/20134 , C12N2760/20171
摘要： The invention provides human antibodies against rabies and methods of using the same.
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公开(公告)号：US20240350107A1
公开(公告)日：2024-10-24
申请号：US18291451
申请日：2022-07-25
发明人： Piotr Zygmanski , Davide Brivio , Erno Sajo
CPC分类号： A61B6/5235 , A61B6/4241 , A61B6/4258 , A61B6/4266
摘要： Systems and methods for detecting and imaging high Z agents within anatomy of a subject are provided. A fast photon counting detector array is positioned relative to the subject to detect coincident photons having 511 keV energy and opposing directions. The trajectories of those photons can be determined, thereby leading to the origin of the photons, namely, the location of an annihilation event. Based on the number of these events, the high Z agent can be detected and/or imaged within the anatomy, thereby providing useful information for clinicians regarding the distribution of high Z agents in the anatomy and/or the behavior of the therapeutic medical high energy photon source.
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公开(公告)号：US12115686B2
公开(公告)日：2024-10-15
申请号：US17830831
申请日：2022-06-02
发明人： Takahide Yoshiike , Christopher Garry , Frank Charles Sup, IV , Soumitra P. Sitole , Mark A. Price
CPC分类号： B25J9/1697 , B25J9/1664 , G06F3/015 , G06T7/20 , G06F3/012 , G06F3/013 , G06F3/014 , G06T2207/20081 , H04N7/183
摘要： An operation system and an operation method that may improve operability are provided. The operation system includes a circuitry configured to determine a predicted value of an operator motion after a predetermined prediction latency from a current time based on a bio-signal using a prescribed machine learning model, the bio-signal captured from the operator and a controller configured to control a motion of a robot based on the predicted value. The operation method includes a step of determining a predicted value of an operator motion after a predetermined latency from the current time based on a bio-signal using a prescribed machine learning model, the bio-signal captured from the operator, and a step of controlling a motion of a robot on the predicted value.
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公开(公告)号：US20240324881A1
公开(公告)日：2024-10-03
申请号：US18683122
申请日：2022-08-23
CPC分类号： A61B5/0075 , A61B5/01 , A61N5/067 , A61N2005/0628 , A61N2005/063
摘要： The techniques described herein relate to a system including a light source configured to providing a beam of light to a sample of biological tissue, the light source including wavelengths over a range of at least 50 nm: a spectrometer configured for measuring a spectrum of an amount of light reflected from the biological tissue in response to the beam of light provided to the tissue; and a controller configured for directly correlating a temperature of the biological tissue with the spectrum of the light reflected from the biological tissue to determine a temperature of the biological tissue.
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公开(公告)号：US12104183B2
公开(公告)日：2024-10-01
申请号：US17870336
申请日：2022-07-21
发明人： Erik J. Sontheimer , Yan Zhang
CPC分类号： C12N9/22 , C12N15/11 , A61K38/00 , C12N2310/20
摘要： Many strains of the human pathogen Neisseria meningitidis carry a compact Cas9 (NmeCas9) that can serve to limit genetic exchange via natural transformation. Cas9 orthologues (including NmeCas9) have recently been adopted for RNA-guided genome engineering and DNA binding, adding to the need to define better their activities and properties. The present invention examines DNA cleavage activities and substrate requirements of NmeCas9, including a set of unusually complex PAM recognition patterns. Unexpectedly, NmeCas9 is found able to cleave single-stranded DNA (ssDNA) targets in a manner that is RNA-guided but both PAM- and tracrRNA-independent. Beyond the requirement for guide-target pairing, this activity has no apparent sequence requirements, and the cleavage sites are measured from the 5′ end of the DNA substrate's RNA-paired region. These results indicate that tracrRNA domains are not strictly required for enzymatic activation of NmeCas9, and expand the list of targeting activities exhibited by these revolutionary RNA-guided nucleases.
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公开(公告)号：US12098381B2
公开(公告)日：2024-09-24
申请号：US17200398
申请日：2021-03-12
发明人： Thoru Pederson , Scot Andrew Wolfe , Hanhui Ma , Metewo Selase Kosi Enuameh , Nicola Anne Kearns , Ryan Michael Jude Genga , Rene Maehr , Shaojie Zhang , Ardalan Naseri , Manuel Garber
IPC分类号： C12N15/85 , C12N5/0735 , C12N5/074 , C12N9/22 , C12N15/63 , C12N15/86 , C12N15/90 , C12Q1/6841
CPC分类号： C12N15/86 , C12N5/0606 , C12N5/0696 , C12N9/22 , C12N15/63 , C12N15/907 , C12Q1/6841 , C12N2501/65 , C12N2501/70 , C12N2510/00 , C12N2740/15043
摘要： The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal CRISPR/Cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state.
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公开(公告)号：US12096561B2
公开(公告)日：2024-09-17
申请号：US17515870
申请日：2021-11-01
发明人： Craig A. Armiento , Yuri Piro , Andrew M. Luce , Emily Lamport , Oshadha Ranasingha , Christopher R. Areias , Christopher N. Kuncho , Alkim Akyurtlu , Edward D. Kingsley
IPC分类号： H05K1/18 , C09D11/037 , C09D11/101 , C09D11/102 , H05K3/30
CPC分类号： H05K1/183 , C09D11/037 , C09D11/101 , C09D11/102 , H05K3/30 , H05K2201/0112 , H05K2201/0137 , H05K2201/0209
摘要： A chip-embedded printed circuit board includes a cavity in a printed circuit board, a chip in the cavity of the printed circuit board, and a thixotropic dielectric filler in a gap in the cavity to seal the chip in the printed circuit board.
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公开(公告)号：US12091659B2
公开(公告)日：2024-09-17
申请号：US16879914
申请日：2020-05-21
IPC分类号： C12N15/10 , C07K14/005 , C40B40/08
CPC分类号： C12N15/1065 , C07K14/005 , C40B40/08 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14171
摘要： Aspects of the disclosure relate to barcoded chimeric adeno-associated virus (AAV) capsid libraries, chimeric capsids and related recombinant AAVs (rAAVs) identified using the libraries. Specifically, the chimeric AAV capsid libraries comprise a plurality of nucleic adds encoding AAV capsid proteins, wherein each nucleic acid (i) encodes a unique AAV capsid protein having distinct polypeptide regions of greater than six amino acids in length that are derived from at least two different AAV serotypes, and (ii) comprises a unique barcode sequence. Further disclosed are methods of preparing an AAV library and identifying AAV capsids tropic for a target tissue.
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公开(公告)号：US20240301410A1
公开(公告)日：2024-09-12
申请号：US18430581
申请日：2024-02-01
发明人： Anastasia Khvorova , Julia Alterman , Socheata Ly , Faith Conroy , Daniel O'Reilly , Sarah Allen
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/351
摘要： This disclosure relates to novel HTT-1A targeting sequences. Novel HTT-1A targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
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公开(公告)号：US20240294615A1
公开(公告)日：2024-09-05
申请号：US18408793
申请日：2024-01-10
CPC分类号： C07K16/1217 , A61P31/04 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/734
摘要： Provided are humanized antibodies that bind to the 2C7 epitope of Neisseria gonorrhoeae. Also provided are compositions and methods for treating Neisseria gonorrhoeae infection in a subject in need thereof.
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