公开(公告)号：US11526994B1

公开(公告)日：2022-12-13

申请号：US17733579

申请日：2022-04-29

申请人： Neosoma, Inc. ,  The University of Bern

发明人： Mauricio Reyes ,  Michael Müller ,  Aly Abayazeed

IPC分类号： G06T7/174 ,  G06V10/764 ,  G06V10/32 ,  G06T7/00 ,  A61B5/00 ,  G06V10/82 ,  G06T3/40 ,  G06T7/62 ,  G01R33/56 ,  G06T7/38

摘要： Systems, methods, and computer program products are provided for segmenting a brain tumor from various MRI sequencing techniques. A plurality of MRI sequences of a head of a patient are received. Each MRI sequence includes a T1-weighted with contrast image, a Fluid Attenuated Inversion Recovery (FLAIR) image, a T1-weighted image, and a T2-weighted image. Each image of the plurality of MRI sequences is registered to an anatomical atlas. A plurality of modified MRI sequences are generated by removing a skull from each image in the plurality of MRI sequences. A tumor segmentation map is determined by segmenting a tumor within a brain in each image in the plurality of modified MRI sequences. The tumor segmentation map is applied to each of the plurality of MRI sequences to thereby generate a plurality of labelled MRI sequences.

公开(公告)号：US20150190534A1

公开(公告)日：2015-07-09

申请号：US14151501

申请日：2014-01-09

申请人： UNIVERSITY OF BERN

发明人： Brigitte FREY ,  Reto BERTOLLINI

IPC分类号： A61K51/04 ,  C07J1/00

CPC分类号： A61K51/0493 ,  C07J1/0022 ,  C07J41/0038

摘要： The present invention relates generally to compounds according to formula I that bind more specifically to mutated androgen receptors than to the wild type androgen receptors and therefore are useful as imaging agents for positron emission tomography (PET) used in the diagnosis and monitoring of prostate cancer.

摘要翻译： 本发明一般涉及比野生型雄激素受体更特异地结合突变的雄激素受体的式I化合物，因此可用作用于诊断和监测前列腺癌的正电子发射断层扫描（PET）的成像剂。

公开(公告)号：US20110165124A1

公开(公告)日：2011-07-07

申请号：US12846356

申请日：2010-07-29

申请人： Pierre-Yves Bochud ,  Andri Rauch

发明人： Pierre-Yves Bochud ,  Andri Rauch

IPC分类号： A61K38/21 ,  C12Q1/68 ,  A61P31/14 ,  A61P31/12

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention relates to in vitro methods of determining a susceptibility to non-response to a hepatitis C treatment or a susceptibility to spontaneous hepatitis C clearance in a subject infected with hepatitis C.

摘要翻译： 本发明涉及确定感染丙型肝炎的受试者对丙型肝炎治疗无应答的敏感性或易发生自发性丙型肝炎清除的体外方法。

公开(公告)号：US6085907A

公开(公告)日：2000-07-11

申请号：US75518

申请日：1998-05-11

申请人： Manfred N. Hochmeister ,  Henry C. Lee

发明人： Manfred N. Hochmeister ,  Henry C. Lee

IPC分类号： A61B10/00 ,  A61B17/32 ,  B65D69/00

CPC分类号： A61B10/0096 ,  A61B2017/320012

摘要： A biological evidence collection apparatus provides contact-free drying, storage, identification, and protection against sample switch and contamination of collected biological samples. The apparatus may include the described forensic evidence collection kit which provides a set of tools for the collection and storage of biological evidence. The collection apparatus may also be used as part of a sexual assault evidence collection kit, or a kit for the collection of buccal swabs, and the like.

摘要翻译： 生物证据收集装置提供无接触的干燥，储存，鉴定和防止样品开关和收集的生物样品的污染。 该装置可以包括所述的法医证据收集包，其提供用于收集和储存生物学证据的一套工具。 收集装置还可以用作性攻击证据收集包或用于收集颊拭子的套件等的一部分。

公开(公告)号：US20180122063A1

公开(公告)日：2018-05-03

申请号：US15856631

申请日：2017-12-28

申请人： Roche Diabetes Care, Inc. ,  University of Bern

发明人： Joachim Dehais ,  Alan Greenburg ,  Sergey Shevchick ,  Abhishek Soni ,  Marios Anthimpoulos ,  Stavroula Mougiakakou

IPC分类号： G06T7/00 ,  G06T7/521 ,  G06K9/66 ,  G06K9/62

CPC分类号： G06T7/0004 ,  G06K9/6201 ,  G06K9/6267 ,  G06K9/66 ,  G06T7/521 ,  G06T2207/10024 ,  G06T2207/30128

摘要： There is disclosed a system for estimating the volume of food on a plate, for example meal, with a mobile device. The system uses a camera and a light pattern projector. Images of the food with and without a projected light pattern on it enable to compute the tridimensional shape and volume, while image segmentation and recognition steps estimate one or more food types in said images. By applying accessible knowledge databases, the carbs content is estimated and the associated insulin bolus doses are provided. Developments comprise coding of the light pattern, different light sources and associated wavelengths, motion compensations, additional optics, estimation of fat content and associated multi-wave boluses. The invention can be implemented in a glucometer or in an insulin pump controller provided with a test strip port or with a mobile phone.

公开(公告)号：US09889023B2

公开(公告)日：2018-02-13

申请号：US13378616

申请日：2010-06-08

申请人： Guoyan Zheng ,  Xiao Dong ,  Lutz-Peter Nolte

发明人： Guoyan Zheng ,  Xiao Dong ,  Lutz-Peter Nolte

IPC分类号： A61F2/46

CPC分类号： A61F2/4657 ,  A61F2/4609 ,  A61F2002/4668

摘要： An acetabular component alignment device for total hip arthroplasty comprises a calibration component allowing for aligning a main instrument axis (5) of the acetabular component depending on a set of two patient specific calibration parameters relating to rotational offsets of the acetabular component, whereas the device is constructed in such a way that calibration parameters may be chosen such that a second parameter of the set of calibration parameters is adjustable independently from a first parameter of the set of calibration parameters by rotating the acetabular component around the main instrument axis (5) of the acetabular component. A method for obtaining patient specific calibration parameters for alignment of an acetabular component in total hip arthroplasty, comprises the steps of determining patient specific morphology information relating to a geometry of the patient's pelvis; and processing the patient specific morphology information for obtaining a set of two patient specific calibration parameters relating to rotational offsets of the acetabular component. The calibration parameters are chosen such that a second parameter of the set of calibration parameters may be adjusted independently from a first parameter of the set of calibration parameters by rotating the acetabular component around a main instrument axis of the acetabular component.

公开(公告)号：US09157114B2

公开(公告)日：2015-10-13

申请号：US13899122

申请日：2013-05-21

申请人： University of Bern

发明人： Tosso Leeb

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The invention concerns an in vitro method of determining a genotype relating to hereditary nasal parakeratosis (HNPK) in a dog. According to the invention the presence or the absence of a genetic variation in the SUV39H2 gene sequence is indicative of said disorder. The invention also concerns polypeptide based methods for determining said disorder. Further, nucleic acids, polypeptides and antibodies usable in said method are disclosed.

摘要翻译： 本发明涉及一种在狗中确定与遗传性鼻角化不全（HNPK）有关的基因型的体外方法。 根据本发明，SUV39H2基因序列中遗传变异的存在或不存在表明所述病症。 本发明还涉及用于确定所述病症的基于多肽的方法。 此外，公开了可用于所述方法的核酸，多肽和抗体。

公开(公告)号：US20120172884A1

公开(公告)日：2012-07-05

申请号：US13378616

申请日：2010-06-08

申请人： Guoyan Zheng ,  Xiao Dong ,  Lutz-Peter Nolte

发明人： Guoyan Zheng ,  Xiao Dong ,  Lutz-Peter Nolte

IPC分类号： A61F2/34

CPC分类号： A61F2/4657 ,  A61F2/4609 ,  A61F2002/4668

摘要： An acetabular component alignment device for total hip arthroplasty comprises a calibration component (9) allowing for aligning a main instrument axis (5) of the acetabular component depending on a set of two patient specific calibration parameters relating to rotational offsets of the acetabular component, whereas the device is constructed in such a way that calibration parameters may be chosen such that a second parameter of the set of calibration parameters is adjustable independently from a first parameter of the set of calibration parameters by rotating the acetabular component around the main instrument axis (5) of the acetabular component. A method for obtaining patient specific calibration parameters for alignment of an acetabular component in total hip arthroplasty, comprises the steps of determining patient specific morphology information relating to a geometry of the patient's pelvis; and processing the patient specific morphology information for obtaining a set of two patient specific calibration parameters relating to rotational offsets of the acetabular component. The calibration parameters are chosen such that a second parameter of the set of calibration parameters may be adjusted independently from a first parameter of the set of calibration parameters by rotating the acetabular component around a main instrument axis of the acetabular component.

摘要翻译： 用于全髋关节置换的髋臼部件对准装置包括校准部件（9），其允许根据与髋臼部件的旋转偏移相关的一组两个患者特定校准参数来对准髋臼部件的主仪器轴线（5），而 该装置被构造成使得校准参数可以被选择为使得该组校准参数的第二参数可以独立于该组校准参数的第一参数来调节，使得髋臼部件绕主仪器轴线旋转（5 ）髋臼部件。 一种用于获得用于在全髋关节置换术中对准髋臼部件的患者特异性校准参数的方法包括以下步骤：确定与患者骨盆几何形状有关的患者特异性形态学信息; 以及处理所述患者特定形态学信息，以获得与所述髋臼部件的旋转偏移相关的一组两个患者特异性校准参数。 选择校准参数，使得可以通过围绕髋臼部件的主仪器轴线旋转髋臼分量来独立于该组校准参数组的第一参数来调整该组校准参数的第二参数。

公开(公告)号：US07598067B2

公开(公告)日：2009-10-06

申请号：US11421658

申请日：2006-06-01

申请人： Joseph A. Beavo ,  Thomas Seebeck ,  Scott Haydn Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewei Gong ,  Natalie Glavas

发明人： Joseph A. Beavo ,  Thomas Seebeck ,  Scott Haydn Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewei Gong ,  Natalie Glavas

IPC分类号： C12N15/79 ,  C12N15/80 ,  C12N15/81 ,  C12N9/16 ,  C12Q1/68

CPC分类号： C07H21/04 ,  A61K38/00 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

摘要翻译： 本发明提供编码本发明的新型PDE蛋白的分离的全长核酸分子及其用途的方法。 本发明的核酸分子还包括与本发明的核酸分子反应的肽核酸（PNA）和反义分子。 本发明还涉及新型PDE蛋白的活性的激动剂，抗体，拮抗剂或抑制剂。 这些组合物可用于诊断，预防或治疗与新型PDE蛋白的存在或不足相关的病症。

公开(公告)号：US20050214248A1

公开(公告)日：2005-09-29

申请号：US10524357

申请日：2003-08-12

申请人： Robert Rieben ,  Paul Mohacsi ,  Nicolai Bovin ,  Elena Korchagina

发明人： Robert Rieben ,  Paul Mohacsi ,  Nicolai Bovin ,  Elena Korchagina

IPC分类号： A61K47/48 ,  A61K31/785 ,  C08F265/02

CPC分类号： A61K47/646

摘要： The present invention relates to new non-glycosylated polyacrylamide conjugates, a method for protecting endothelial cells from complement-mediated cellular damage and the use of said non-glycosylated polyacrylamide conjugates as a medicament.

摘要翻译： 本发明涉及新的非糖基化聚丙烯酰胺缀合物，一种保护内皮细胞免受补体介导的细胞损伤的方法，以及使用所述非糖基化的聚丙烯酰胺缀合物作为药物。