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1.发明申请公开(公告)号：US20140112892A1
公开(公告)日：2014-04-24
申请号：US14111757
申请日：2012-04-02
申请人： Goshi Shiota , Yoshiko Hoshikawa , Noriko Matsumoto , Yoshiaki Matsumi , Minoru Morimoto , Takayuki Tonoi , Hiroyuki Saimoto , Kazuo Ohashi , Teruo Okano
发明人： Goshi Shiota , Yoshiko Hoshikawa , Noriko Matsumoto , Yoshiaki Matsumi , Minoru Morimoto , Takayuki Tonoi , Hiroyuki Saimoto , Kazuo Ohashi , Teruo Okano
IPC分类号： A61K35/407
CPC分类号： A61K35/407 , A61L27/3804 , A61L27/3834 , A61L2430/28 , C07C43/225 , C07C251/86 , C07D307/52 , C07D487/04
摘要： The purpose is to select low-molecular-weight compounds which are effective in inducing differentiation of mesenchymal stem cell into hepatocyte and to develop a safe differentiation-inducing method having excellent efficiency of differentiating mesenchymal stem cell into hepatocyte. Provided are at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; a differentiation inducer comprising at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; and a differentiation inducer comprising a compound represented by formula (8), a salt thereof, or a solvate of them.
摘要翻译： 目的是选择有效诱导间充质干细胞分化为肝细胞的低分子量化合物，并开发出一种安全的分化诱导方法，其具有优良的间充质干细胞分化为肝细胞的效率。 提供至少一种选自由式（1）和（2）表示的化合物，其盐或它们的溶剂化物的化合物; 包含至少一种选自由式（1）和（2）表示的化合物，其盐或它们的溶剂化物的化合物的分化诱导剂; 以及包含由式（8）表示的化合物，其盐或它们的溶剂合物的分化诱导剂。
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公开(公告)号：US20190358480A1
公开(公告)日：2019-11-28
申请号：US16098389
申请日：2018-07-06
发明人： Toshimitsu MYOGA , Koichi TAKAHASHI , Kazuhiro IIZUKA , Yuhei MATSUBARA , Toshiyuki TANAKA , Hisaki OKAMOTO
IPC分类号： A62D3/36
摘要： The method for detoxifying asbestos disclosed here includes: preparing an asbestos-containing substance that contains at least one type of asbestos; preparing an asbestos treatment agent that contains a mineral acid, N-methyl-2-pyrrolidone and a fluoride; and bringing the asbestos-containing substance into contact with the asbestos treatment agent so as to detoxify asbestos in the asbestos-containing substance. Due to this configuration, asbestos in the asbestos-containing substance can be favorably detoxified.
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3.发明授权公开(公告)号：US11900509B2
公开(公告)日：2024-02-13
申请号：US16966486
申请日：2019-01-30
CPC分类号： G06T11/005 , G01N15/1475 , G06T7/0012 , G06T7/70 , G01N2015/0065 , G06T2207/10101 , G06T2207/30024
摘要： A technique capable of providing a user with information obtained by OCT imaging in a useful way, particularly for assisting in assessment of an embryo effectively. The image processing method includes acquiring original signal data indicating an intensity distribution of signal light from each position in three-dimensional space including a cultured embryo obtained by optical coherence tomography imaging, generating spherical coordinate data based on the original signal data, the spherical coordinate data indicating a relationship between each position in the three-dimensional space represented using spherical coordinates having an origin set inside the embryo and the intensity of the signal light from the position, and outputting the intensity distribution of the signal light as a two-dimensional map based on the spherical coordinate data using two deflection angles of the spherical coordinates as coordinate axes.
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公开(公告)号：US11710237B2
公开(公告)日：2023-07-25
申请号：US16966488
申请日：2019-01-30
CPC分类号： G06T7/11 , G01N15/1429 , G06T7/0012 , G06T7/12 , G06T7/155 , G06T7/60 , A61B5/0066 , G06T2200/04 , G06T2207/10101 , G06T2207/20152 , G06T2207/30024 , G06T2207/30044
摘要： A data processing method that is suitable for obtaining quantitative information from data obtained by OCT imaging. The image processing method includes acquiring original image data corresponding to a three-dimensional image of a cultured embryo obtained by optical coherence tomography imaging of the embryo and executing a region segmentation the three-dimensional image into a plurality of regions on the basis of the original image data. In the region segmentation, a local thickness calculation is performed on the three-dimensional image to determine an index value indicating a size of an object included in the three-dimensional image, the three-dimensional image is segmented into a region indicated by the index value greater than a predetermined first threshold and a region indicated by the index value less than the first threshold, and each of the regions resulting from the segmentation is further segmented by the watershed algorithm.
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公开(公告)号：US20230117252A1
公开(公告)日：2023-04-20
申请号：US18053847
申请日：2022-11-09
发明人： Goshi SHIOTA , Noriko ITABA , Yohei KONO
IPC分类号： C12N5/0775 , A61K35/28
摘要： [Problem to be solved by the invention] To provide a cell sheet for increasing fibrosis inhibitory action, said cell sheet comprising bone marrow mononuclear cells, and a production method thereof. [Solution] A cell sheet comprising bone marrow mononuclear cells, said cell sheet being obtained by forming bone marrow mononuclear cells from a bone marrow mononuclear cell suspension into a sheet, and then shrinking and suspension culturing the result.
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公开(公告)号：US11344589B2
公开(公告)日：2022-05-31
申请号：US16863024
申请日：2020-04-30
IPC分类号： A61K35/768 , A61P35/00 , C12N15/863 , C12N7/00 , C07K14/005
摘要： The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a recombinant vaccinia virus lacking functions of VGF and O1L and having a gene encoding B5R in which an SCR domain has been deleted. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.
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公开(公告)号：US11344539B2
公开(公告)日：2022-05-31
申请号：US15998949
申请日：2017-02-17
申请人： NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY , Takeshi Nishino , Ken Okamoto , Teijin Pharma Limited
发明人： Takeshi Nishino , Shinsuke Kato , Masako Kato , Hidenori Suzuki , Ken Okamoto
IPC分类号： A61K31/4439 , A61P25/28 , A61K9/00 , A61K31/426 , A61K31/427
摘要： The present invention provides a therapeutic agent or a prophylactic agent of dementia containing xanthine oxidase inhibitor such as a compound represented in formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof as an active ingredient.
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公开(公告)号：US20210095311A1
公开(公告)日：2021-04-01
申请号：US16981164
申请日：2019-03-15
发明人： Yasuhiro KAZUKI , Mitsuo OSHIMURA , Satoshi ABE
IPC分类号： C12N15/85 , A01K67/027 , C07K16/00
摘要： A mouse artificial chromosome vector is stable in rodent cells, tissues, and/or individuals, specifically a mouse artificial chromosome vector derived from a mouse chromosome selected from mouse chromosome 10 and mouse chromosome 16. A cell or a non-human animal may include the vector. The vector may be used for producing proteins and human antibodies.
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公开(公告)号：US20200332315A1
公开(公告)日：2020-10-22
申请号：US16760686
申请日：2018-11-02
发明人： Yasuhiro KAZUKI , Takahito OHIRA , Narumi UNO , Hiroyuki KUGOH , Mitsuo OSHIMURA
IPC分类号： C12N15/85 , C12N15/90 , C07K14/435 , A01K67/027
摘要： This application provides: a nucleic acid construct characterized by comprising, in a mammalian artificial chromosome vector, a DNA sequence of interest, a matrix attachment region, and a replication origin, and by using for high expression of the DNA; a mammalian cell comprising the nucleic acid construct; and a method for high production of a protein encoded by the DNA of interest in the mammalian cell.
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公开(公告)号：US10729926B2
公开(公告)日：2020-08-04
申请号：US16098389
申请日：2018-07-06
发明人： Toshimitsu Myoga , Koichi Takahashi , Kazuhiro Iizuka , Yuhei Matsubara , Toshiyuki Tanaka , Hisaki Okamoto
IPC分类号： A62D3/36 , A62D101/41
摘要： The method for detoxifying asbestos disclosed here includes: preparing an asbestos-containing substance that contains at least one type of asbestos; preparing an asbestos treatment agent that contains a mineral acid, N-methyl-2-pyrrolidone and a fluoride; and bringing the asbestos-containing substance into contact with the asbestos treatment agent so as to detoxify asbestos in the asbestos-containing substance. Due to this configuration, asbestos in the asbestos-containing substance can be favorably detoxified.
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