公开(公告)号：US20160317053A1

公开(公告)日：2016-11-03

申请号：US15096031

申请日：2016-04-11

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Nishant R. Srivastava

IPC: A61B5/04 ,  A61B18/02 ,  A61N7/02 ,  A61B18/14 ,  A61B5/00

CPC classification number: A61B5/04001 ,  A61B5/6852 ,  A61B17/320068 ,  A61B18/02 ,  A61B18/1492 ,  A61B2017/00039 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/0212 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61N7/022

Abstract: Neuromodulation catheters with nerve monitoring features for transmitting digital neural signals and associated systems and methods are disclosed herein. A neuromodulation catheter configured in accordance with some embodiments of the present technology can include, for example, a handle and an elongated shaft attached to the handle. The shaft can have a proximal portion and a distal portion configured to be moved within a lumen of a blood vessel of a human patient. The neuromodulation catheter can further include an array of contacts at the distal portion of the shaft and a digitizer at the handle or the shaft. The contacts can be configured to detect analog neural signals from within the blood vessel. The digitizer can be configured to receive the analog neural signals from the contacts, digitize the analog neural signals into digital neural signals, and transmit the digital neural signals to a read/write module external to the patient.

公开(公告)号：US11515029B2

公开(公告)日：2022-11-29

申请号：US16988068

申请日：2020-08-07

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Carol Sullivan ,  Neil Barman ,  Dwayne S. Yamasaki

IPC: A61B5/00 ,  G16H20/30 ,  A61N2/00 ,  G16H50/30 ,  G16H20/40 ,  A61B18/02 ,  A61F7/12 ,  A61N7/00 ,  A61B5/145 ,  A61B18/00 ,  A61N7/02 ,  A61F7/00 ,  A61B5/024 ,  A61B18/14 ,  A61N1/36 ,  G16H10/20

Abstract: Methods for treating and managing pain in a patient with therapeutic neuromodulation and associated systems and methods are disclosed herein. Chronic or debilitating pain can be associated, for example, with a disease or condition of the abdominal or reproductive viscera. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a target blood vessel of a diseased or damaged organ of a patient experiencing pain. Targeted sympathetic nerve activity can be modulated at least along afferent pathways which can improve a measurable parameter associated with the pain of the patient The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.

公开(公告)号：US11413084B2

公开(公告)日：2022-08-16

申请号：US16456255

申请日：2019-06-28

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Gabriel Lazarus ,  Douglas Hettrick

IPC: A61B18/00 ,  A61F7/12 ,  G16H20/60 ,  G16H20/40 ,  A61B17/32 ,  A61B18/14 ,  A61B18/02

Abstract: Methods for treating eating disorders and for reducing a risk associated with developing an eating disorder in patients via therapeutic renal neuromodulation and associated systems. Renal sympathetic nerve activity can be attenuated to improve a patient's eating disorder status or risk of developing an eating disorder. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to modulate the renal sympathetic nerve.

公开(公告)号：US11406437B2

公开(公告)日：2022-08-09

申请号：US16690718

申请日：2019-11-21

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Micheal Moriarty ,  Brian Kelly

IPC: A61B18/02 ,  A61B18/00 ,  A61B90/00

Abstract: A method of using a cryotherapeutic system in accordance with a particular embodiment includes advancing an elongate shaft of a catheter toward a treatment location within a body lumen of a human patient and directing a flow of refrigerant toward a cryotherapeutic element at a distal end portion of the shaft. The directed refrigerant is expanded to cause cooling within a balloon of the cryotherapeutic element. The pressure within the balloon is monitored and its rate of change calculated. The rate of change is then processed using different feedback loops during different monitoring windows of a treatment cycle. The individual feedback loops include an upper and a lower threshold and are configured to cause the flow of refrigerant to the cryotherapeutic element to stop if the rate of change falls outside a range between the upper and the lower threshold.

公开(公告)号：US11311205B2

公开(公告)日：2022-04-26

申请号：US16451395

申请日：2019-06-25

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Douglas Hettrick ,  Avram Scheiner

IPC: A61B18/12 ,  A61B18/14 ,  A61B5/0538 ,  A61B5/00 ,  A61M25/00 ,  A61N1/05 ,  A61B18/00

Abstract: Systems and methods for evaluating neuromodulation via hemodynamic responses are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a neuromodulation catheter comprising an elongated shaft having a distal portion, and a plurality of electrodes spaced along a distal portion. The system can further include a controller communicatively coupled to the electrodes. The controller can be configured to apply first and second stimuli at and/or proximate to a target site within a blood vessel before and after delivering neuromodulation energy to the target site, and detect, via at least one of the electrodes, vessel impedance resulting from the first and second stimuli to determine a baseline impedance and a post-neuromodulation impedance. The controller can further be configured to assess the efficacy of the neuromodulation based, at least in part, on a comparison of the baseline impedance and the post-neuromodulation impedance.

公开(公告)号：US11304749B2

公开(公告)日：2022-04-19

申请号：US16191000

申请日：2018-11-14

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Douglas A. Hettrick ,  Julie Trudel ,  Paul Coates ,  Robert J. Melder ,  Stefan S. Tunev ,  Martin Rothman ,  Sean Salmon

IPC: A61B18/14 ,  A61B5/00 ,  A61B5/0538 ,  A61B18/12 ,  A61B18/16 ,  A61B18/00 ,  A61B5/0531

Abstract: Systems and methods for neuromodulation therapy are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a plurality of reference electrodes at the skin of a human patient and intravascularly positioning a plurality of ablation electrodes within a blood vessel lumen at a treatment site. The method can include obtaining impedance measurements between different combinations of the reference electrodes and the ablation electrodes and, based on the impedance measurements, identifying two or more electrode groups for treatment, where at least two of the electrode groups include a different one of the reference electrodes and a different one of the ablation electrodes.

公开(公告)号：US11253189B2

公开(公告)日：2022-02-22

申请号：US15959004

申请日：2018-04-20

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Abhijeet Dubhashi ,  Douglas Hettrick ,  Guo Xu

IPC: A61B5/00 ,  A61B5/04 ,  G01R33/032 ,  A61B18/14 ,  A61B5/24 ,  A61B5/242 ,  A61B18/00 ,  A61B18/18 ,  G01R33/26 ,  A61B90/00 ,  A61B18/02 ,  A61B17/32

Abstract: Systems and methods for measuring the magnetic fields generated by renal nerves before and/or after neuromodulation therapy are disclosed herein. One method for measuring the magnetic field of target nerves during a neuromodulation procedure includes positioning a neuromodulation catheter at a target site within a renal blood vessel of a human patient near the target nerves, and detecting a measurement of the magnetic field generated by the target nerves. The method can further include determining, based on the measurement of the magnetic field, a location of the target nerves, a location of ablation at the target nerves, and/or a percentage the target nerves were ablated by delivered neuromodulation energy.

公开(公告)号：US20210330378A1

公开(公告)日：2021-10-28

申请号：US17365868

申请日：2021-07-01

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Denise Zarins ,  Hanson Gifford, III ,  Mark E. Deem ,  Douglas Sutton ,  Howard R. Levin ,  Mark Gelfand

IPC: A61B18/14 ,  A61N1/05 ,  A61M5/142 ,  A61N1/36 ,  A61N1/32 ,  A61N7/02 ,  A61F7/12 ,  A61N7/00

Abstract: Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

公开(公告)号：US11154351B2

公开(公告)日：2021-10-26

申请号：US15516349

申请日：2015-11-14

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Martin Rothman ,  Paul Coates

IPC: A61B18/14 ,  A61B18/02 ,  G01R5/26 ,  A61B18/00 ,  A61N7/00 ,  A61B90/00

Abstract: Devices and systems for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.

公开(公告)号：US20210267674A1

公开(公告)日：2021-09-02

申请号：US17306541

申请日：2021-05-03

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Ayala Hezi-Yamit ,  Susan Edwards ,  Carol Sullivan

IPC: A61B18/14 ,  A61N7/02 ,  A61B18/24

Abstract: Provided herein are methods, systems, and devices for increasing heat shock protein expression and treating conditions for which increased heat shock protein expression is expected to be beneficial using thermal ablation.