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1.发明授权公开(公告)号：US09206163B2
公开(公告)日：2015-12-08
申请号：US14381546
申请日：2013-03-22
发明人： Sanjay Kumar Dehury , Venkata Lakshmi Narasimha Dammalapati , Venkata Sunil Kumar Indukuri , Seeta Ramanjaneyulu Gorantla
IPC分类号： C07D403/06 , A61K31/404 , C07C53/134 , C07C55/07 , C07C55/10 , C07C59/245
CPC分类号： C07D403/06 , A61K31/404 , C07C53/134 , C07C55/07 , C07C55/10 , C07C59/245
摘要： The present invention relates to an improved process for the preparation of Sunitinb. The process involves the activation of 5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene) methyl)-2,4-dimethyl-1 H-pyrrole-3carboxylic acid to corresponding suitable carboxylic acid activating group. The present invention also relates to novel acid addition salts of Sunitinb and preparation thereof.
摘要翻译： 本发明涉及一种改进的Sunitinb的制备方法。 该方法涉及5 - （（Z） - （5-氟-2-氧代二氢吲哚-3-亚基）甲基）-2,4-二甲基-1H-吡咯-3-羧酸与相应的适合的羧酸活化基团的活化。 本发明还涉及新丝氨酸的新型酸加成盐及其制备方法。
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![PROCESS FOR THE PREPARATION OF GEMCITABINE-[PHENYL(BENZOXY-L-ALANINYL)] PHOSPHATE](/abs-image/US/2017/06/15/US20170166602A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170166602A1
公开(公告)日：2017-06-15
申请号：US15411409
申请日：2015-07-22
摘要： The present invention provides a process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate of Formula I in high yield and purity.
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公开(公告)号：US09650346B2
公开(公告)日：2017-05-16
申请号：US13985172
申请日：2012-04-09
申请人： Venkata S. Indukuri , Vamsee K. Muppidi , Sree R. Joga , Seeta R. Gorantla , Satyanarayana Chava
发明人： Venkata S. Indukuri , Vamsee K. Muppidi , Sree R. Joga , Seeta R. Gorantla , Satyanarayana Chava
IPC分类号： A01N57/00 , A61K31/675 , C07D235/06 , A61K31/513 , A61K31/519 , C07D417/04 , C07D473/16 , C07F9/6561 , C07D411/04
CPC分类号： C07D235/06 , A61K31/513 , A61K31/519 , A61K31/675 , C07D411/04 , C07D417/04 , C07D473/16 , C07F9/65616
摘要： Disclosed are solid forms of antiretroviral compounds and anti-oxidative acids, and processes for their preparation. Pharmaceutical compositions using the solid forms are also disclosed.
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公开(公告)号：US09573902B2
公开(公告)日：2017-02-21
申请号：US14768082
申请日：2014-02-14
发明人： Suresh Thatipally , Venkata Lakshmi Narasimha Rao Dammalapati , Seeta Ramanjaneyulu Gorantla , Satyanarayana Chava
IPC分类号： A61K31/47 , C07D215/56 , C07D215/48 , C07C227/14 , C07C227/18 , C07C229/30
CPC分类号： C07D215/56 , A61K31/47 , C07C227/14 , C07C227/18 , C07C229/30 , C07D215/48 , C07C229/34
摘要： The present invention provides novel intermediates of ivacaftor and process for its preparation. The present invention also provides process for the preparation of ivacaftor and pharmaceutically acceptable salt thereof using novel intermediates.
摘要翻译： 本发明提供了新颖的ivacaftor的中间体及其制备方法。 本发明还提供了使用新型中间体制备叶斑病及其药学上可接受的盐的方法。
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公开(公告)号：US09156885B2
公开(公告)日：2015-10-13
申请号：US14235349
申请日：2012-07-26
申请人： Subha Nair Velayudhan , Ravindra Babu Bollu , Venkata Sunil Kumar Indukuri , Seeta Ramanjaneyulu Gorantla , Venkata Siva RamaKrishna Reddy Kallam , Bala Muralikrishna Madivada
发明人： Subha Nair Velayudhan , Ravindra Babu Bollu , Venkata Sunil Kumar Indukuri , Seeta Ramanjaneyulu Gorantla , Venkata Siva RamaKrishna Reddy Kallam , Bala Muralikrishna Madivada
摘要： The present invention provides processes for preparation of eptifibatide that involve coupling of amino acids in a (2+5), (4+3) and (3+4) sequence method. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide.
摘要翻译： 本发明提供了以（2 + 5），（4 + 3）和（3 + 4）序列方法偶联氨基酸的依替巴肽的制备方法。 本发明还提供通过所述方法生产的产物，可用作制备埃替非巴肽的合成中间体的新化合物。
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公开(公告)号：US10774104B2
公开(公告)日：2020-09-15
申请号：US16060681
申请日：2016-12-09
摘要： Disclosed is a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. Also disclosed is a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.
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7.发明授权Salts of sitagliptin, process for the preparation and pharmaceutical composition therefore 有权西他列汀的盐，因此制备方法和药物组合物公开(公告)号：US09181256B2
公开(公告)日：2015-11-10
申请号：US13985490
申请日：2012-10-12
发明人： Venkata Sunil Kumar Indukuri , Seeta Ramanjaneyulu Gorantla , Vamsee Krishna Muppidi , Satyanarayana Chava
IPC分类号： C07D487/04 , A61K31/4985 , C07C57/42
CPC分类号： C07C57/42 , A61K31/4985 , C07D487/04
摘要： The present invention relates to pharmaceutically acceptable acid addition salts of sitagliptin, in particular anti-oxidant acid addition salts of sitagliptin and a process for its preparation. The present invention also provides a pharmaceutical composition using the pharmaceutically acceptable acid addition salts of sitagliptin.
摘要翻译： 本发明涉及西格列汀的药学上可接受的酸加成盐，特别是西格列汀的抗氧化酸加成盐及其制备方法。 本发明还提供了使用西格列汀的药学上可接受的酸加成盐的药物组合物。
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公开(公告)号：US09056882B2
公开(公告)日：2015-06-16
申请号：US14356609
申请日：2012-11-15
申请人： Venkata Sunil Kumar Indukuri , Sree Rambabu Joga , Seeta Ramanjaneyulu Gorantla , Satyanarayana Chava
发明人： Venkata Sunil Kumar Indukuri , Sree Rambabu Joga , Seeta Ramanjaneyulu Gorantla , Satyanarayana Chava
IPC分类号： A61K31/675 , C07F9/6561
CPC分类号： C07F9/65616 , A61K31/675
摘要： The present invention provides a process for preparation of tenofovir by dealkylation of its phosphonate ester using Ionic complexes. The present invention also provides a process for preparation of tenofovir disoproxil or a salt thereof using the tenofovir of the present invention.
摘要翻译： 本发明提供了使用离子配合物通过其膦酸酯的脱烷基化制备替诺福韦的方法。 本发明还提供了使用本发明的替诺福韦来制备替诺福韦地斯普利或其盐的方法。
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9.发明授权Process for the preparation of polyhydroxystilbene compounds by deprotection of the corresponding ethers 有权通过脱保护相应的醚来制备多羟基茋化合物的方法公开(公告)号：US08987525B2
公开(公告)日：2015-03-24
申请号：US14353869
申请日：2012-11-30
IPC分类号： C07C37/055
CPC分类号： C07C37/055 , C07C39/23
摘要： A process for the preparation of polyhydroxystilbene compounds (particularly resveratrol, oxyresveratrol, piceatannol, gnetol and the like) by deprotection of the corresponding ethers using aluminum halide and a secondary amine is provided.
摘要翻译： 提供了通过使用卤化铝和仲胺对相应的醚进行脱保护来制备多羟基茋化合物（特别是白藜芦醇，氧基白藜芦醇，吡哆醇，胶体等）的方法。
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