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公开(公告)号：US10774104B2
公开(公告)日：2020-09-15
申请号：US16060681
申请日：2016-12-09
摘要： Disclosed is a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. Also disclosed is a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.
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![PROCESS FOR THE PREPARATION OF GEMCITABINE-[PHENYL(BENZOXY-L-ALANINYL)] PHOSPHATE](/abs-image/US/2017/06/15/US20170166602A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170166602A1
公开(公告)日：2017-06-15
申请号：US15411409
申请日：2015-07-22
摘要： The present invention provides a process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate of Formula I in high yield and purity.
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![Process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate](/abs-image/US/2017/12/05/US09834577B2/abs.jpg.150x150.jpg)
公开(公告)号：US09834577B2
公开(公告)日：2017-12-05
申请号：US15411409
申请日：2015-07-22
摘要： The present invention provides a process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate of Formula I in high yield and purity.
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![SYNTHESIS OF 3'-DEOXYADENOSINE-5'-O-[PHENYL(BENZYLOXY-L-ALANINYL)]PHOSPHATE (NUC-7738)](/abs-image/US/2020/06/11/US20200181190A1/abs.jpg.150x150.jpg)
4.发明申请公开(公告)号：US20200181190A1
公开(公告)日：2020-06-11
申请号：US16623272
申请日：2018-06-14
申请人： NuCana plc
IPC分类号： C07H19/207
摘要： The present invention generally relates to a novel process for the preparation of 3′-deoxyadenosine derivatives, and particularly NUC-7738 (3′-deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of deoxyadenosine.
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公开(公告)号：US20220402962A1
公开(公告)日：2022-12-22
申请号：US17888312
申请日：2022-08-15
申请人： NuCana plc
IPC分类号： C07H19/207 , C07H1/02 , C07H19/10 , C07H19/20
摘要： The present invention is a process for the preparation of certain 5′-phosphoramidate nucleotide diastereoisomers. The phosphoramidates include those useful in the treatment of cancer such as NUC-3373 (5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzyloxy-L-alaninyl)]phosphate].
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公开(公告)号：US20210009625A1
公开(公告)日：2021-01-14
申请号：US16991765
申请日：2020-08-12
申请人： NuCana plc
摘要： The present invention provides a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. It also provides a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.
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公开(公告)号：US11603382B2
公开(公告)日：2023-03-14
申请号：US16991765
申请日：2020-08-12
申请人： NuCana plc
摘要： The present invention provides a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. It also provides a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.
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![Synthesis of 3′-deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)]phosphate (NUC-738)](/abs-image/US/2024/02/13/US11897913B2/abs.jpg.150x150.jpg)
公开(公告)号：US11897913B2
公开(公告)日：2024-02-13
申请号：US16623272
申请日：2018-06-14
申请人： NuCana plc
IPC分类号： C07H19/207 , C07H1/02 , C07H19/10 , C07H19/20
CPC分类号： C07H19/207 , C07H1/02 , C07H19/10 , C07H19/20
摘要： The present invention generally relates to a novel process for the preparation of 3′-deoxyadenosine derivatives, and particularly NUC-7738 (3′-deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of deoxyadenosine.
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公开(公告)号：US11414451B2
公开(公告)日：2022-08-16
申请号：US16647592
申请日：2018-09-18
申请人： NuCana plc
IPC分类号： C07H1/00 , C07H19/06 , C07H19/073 , C07H19/10
摘要： The present invention relates to a process for the preparation of floxuridine. Floxuridine may be useful as an anti-cancer drug. Floxuridine may also be useful in the preparation of other anti-cancer drugs, e.g. NUC-3373.
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公开(公告)号：US12054511B2
公开(公告)日：2024-08-06
申请号：US17888312
申请日：2022-08-15
申请人： NuCana plc
发明人： Hugh Griffith , Gordon Kennovin , Venkata Lakshmi Narasimha Rao Dammalapati , Mani Bushan Kotala
IPC分类号： C07H19/207 , C07H1/02 , C07H19/10 , C07H19/20
CPC分类号： C07H19/207 , C07H1/02 , C07H19/10 , C07H19/20
摘要： The present invention is a process for the preparation of certain 5′-phosphoramidate nucleotide diastereoisomers. The phosphoramidates include those useful in the treatment of cancer such as NUC-3373 (5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzyloxy-L-alaninyl)]phosphate].
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