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公开(公告)号：US11981687B2
公开(公告)日：2024-05-14
申请号：US17841026
申请日：2022-06-15
申请人： IMMUNOGEN, INC.
IPC分类号： C07D207/452 , C07C205/19 , C07D487/04 , C07D519/00 , C07D519/04
CPC分类号： C07D519/00 , C07C205/19 , C07D207/452 , C07D487/04 , C07D519/04
摘要： The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US11897961B2
公开(公告)日：2024-02-13
申请号：US17711518
申请日：2022-04-01
申请人： IMMUNOGEN, INC.
IPC分类号： A61K39/00 , C07K16/28 , A61K47/68 , A61K39/395
CPC分类号： C07K16/2866 , A61K47/6801 , A61K47/6803 , A61K47/6849 , A61K47/6883 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα). The present invention also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.
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公开(公告)号：US20230391733A1
公开(公告)日：2023-12-07
申请号：US18091653
申请日：2022-12-30
申请人： IMMUNOGEN, INC.
IPC分类号： C07D243/26 , C07D487/04 , C07K16/28 , A61K47/68
CPC分类号： C07D243/26 , C07D487/04 , C07K16/2866 , C07K16/30 , A61K47/6803 , C07K16/2896 , A61K47/6849
摘要： The invention relates to novel methods of preparing cell-binding agent-cytotoxic agent conjugates, wherein the cytotoxic agent is an imine-containing cytotoxic agent bearing a maleimide group. In some embodiments, the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides conjugates prepared by the methods of the present invention, compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.
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公开(公告)号：US11834498B2
公开(公告)日：2023-12-05
申请号：US17838016
申请日：2022-06-10
申请人： ImmunoGen, Inc.
发明人： Olga Ab , Neeraj Kohli , Thomas Chittenden , Julianto Setiady
IPC分类号： C07K16/28 , A61K31/5365 , A61P35/00 , A61K47/68
CPC分类号： C07K16/28 , A61K31/5365 , A61K47/6803 , A61P35/00 , C07K2317/31 , C07K2317/569
摘要： The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies. In a specific aspect, the biparatopic antibodies bind to FRα and modulate FRα activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a biparatopic antibody that specifically binds to FRα and modulates FRα activity.
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公开(公告)号：US11744900B2
公开(公告)日：2023-09-05
申请号：US17371151
申请日：2021-07-09
申请人： ImmunoGen, Inc.
发明人： Xinfang Li , Jared M. Worful
CPC分类号： A61K47/6803 , A61K47/6809 , A61K47/6819 , A61K47/6849 , A61K47/6867 , C07K1/113 , C07K16/2896 , C07K16/32
摘要： The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.
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公开(公告)号：US20230233697A1
公开(公告)日：2023-07-27
申请号：US17973209
申请日：2022-10-25
申请人： IMMUNOGEN, INC.
IPC分类号： A61K47/64 , C07K5/02 , C07K16/28 , C07K5/113 , C07D519/00 , C07D487/04 , C07K5/093 , A61K39/00
CPC分类号： A61K47/64 , C07K5/0202 , C07K16/2866 , C07K16/2863 , C07K5/1021 , C07D519/00 , C07K16/28 , C07D487/04 , C07K5/0819 , C07K2317/24 , A61K2039/505 , C07K2317/92
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US11701428B2
公开(公告)日：2023-07-18
申请号：US16862358
申请日：2020-04-29
申请人： ImmunoGen, Inc.
CPC分类号： A61K47/6849 , A61P35/00 , C07K16/2866
摘要： Therapeutic combinations of immunoconjugates that bind to CD123 (e.g., IMGN632) with BCL-2 inhibitors (e.g., venetoclax), and/or a hypomethylating agent (e.g., azacitidine or decitabine) are provided. Methods of administering the combinations to treat hematological malignancies with clinical efficacy and/or decreased toxicity are also provided. Methods of treating hematological malignances present as minimal residual disease using immunoconjugates that bind to CD123 (e.g., IMGN632) are also provided.
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公开(公告)号：US20230158168A1
公开(公告)日：2023-05-25
申请号：US17940297
申请日：2022-09-08
申请人： Immunogen, Inc.
发明人： Yong DAI , Yong WANG , Shengjin JIN , Deborah H. MESHULAM , Godfrey W. AMPHLETT
CPC分类号： A61K47/6803 , A61K47/6867 , C07K16/2896 , A61K47/6809 , C07K16/2839 , C07K16/2884 , C07K2317/24 , C07K2317/40
摘要： The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
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公开(公告)号：US11198736B2
公开(公告)日：2021-12-14
申请号：US16707940
申请日：2019-12-09
申请人： ImmunoGen, Inc.
发明人： Olga Ab , Daniel Tavares , Juliantro Setiady , Sharron Ladd , Christina N. Carrigan , Lingyun Rui
IPC分类号： C07K16/30 , C07K16/28 , A61K47/68 , A61K39/00 , G01N33/574 , G01N33/547
摘要： The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.
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公开(公告)号：US20210230114A1
公开(公告)日：2021-07-29
申请号：US17143723
申请日：2021-01-07
申请人： IMMUNOGEN, INC.
发明人： Michael Reardon , Richard A. Silva
IPC分类号： C07D207/448 , C07D519/00
摘要： The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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