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公开(公告)号：US20210105980A1
公开(公告)日：2021-04-15
申请号：US17050199
申请日：2019-04-25
摘要： A method of tracking an animal (4) in a population of animals (4) comprises: applying a visual identifier (41) to the animal (4); associating reference identifier data of the visual identifier (41) to animal data of the animal (4); capturing a digital image of the visual identifier (41) applied to the animal (4); recognizing the visual identifier (41) by digitally processing the captured digital image; and identifying the animal (4) upon recognition of the visual identifier (41).
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公开(公告)号：US20180312546A1
公开(公告)日：2018-11-01
申请号：US15981316
申请日：2018-05-16
发明人： Haitao Guo , Dawei Cai , Andrea Cuconati , Changhua Ji
IPC分类号： C07K14/005 , G01N33/50
CPC分类号： C07K14/005 , C07K2319/40 , C07K2319/42 , C12N2730/10122 , C12N2730/10151 , C12N2830/006 , G01N33/502 , G01N2333/02
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
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公开(公告)号：US20240352136A1
公开(公告)日：2024-10-24
申请号：US18687561
申请日：2022-09-02
发明人： Maria Amann , Laurène Pousse , Christophe Boetsch , Martin Weisser , Theresa Kolben , Vaios Karanikas , Jan Eckmann , Bruno Carneiro de Medeiros
IPC分类号： C07K16/28 , A61K31/496 , A61K31/706 , A61K39/395
CPC分类号： C07K16/2866 , A61K31/496 , A61K31/706 , A61K39/3955 , C07K2317/35 , C07K2317/40 , C07K2317/732
摘要： The present invention relates to anti-CD-25 antibodies for use in the treatment of acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL).
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4.发明公开公开(公告)号：US20240339191A1
公开(公告)日：2024-10-10
申请号：US18744107
申请日：2024-06-14
CPC分类号： G16H20/17 , A61B3/0025 , A61B3/102 , A61B3/1225 , G16H50/30
摘要： A method and system for predicting a selected treatment regimen for a subject. Baseline data for a subject diagnosed with neovascular age-related macular degeneration (nAMD) is received. A plurality of predictor inputs is formed for an outcome predictor using the baseline data and regimen data for a plurality of treatment regimens. The plurality of predictor inputs comprises a different predictor input for each of the plurality of treatment regimens. A plurality of treatment scores is generated for the plurality of treatment regimens via the set of outcome predictor using the plurality of predictor inputs. One of the plurality of treatment regimens is selected as a selected treatment regimen for the subject based on the plurality of treatment scores.
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公开(公告)号：US20240338826A1
公开(公告)日：2024-10-10
申请号：US18578723
申请日：2022-07-14
CPC分类号： G06T7/0014 , G06V10/267 , G06V10/82 , G06T2207/20081 , G06T2207/20084 , G06T2207/30024 , G06T2207/30092
摘要： Systems and methods disclosed herein relate generally to systems and methods for detection, segmentation and characterization of isolated or overlapping object instances in digital images, applicable for detection, segmentation and characterization of crypts in histological images from patients with gastrointestinal disorders.
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6.发明公开公开(公告)号：US20240338823A1
公开(公告)日：2024-10-10
申请号：US18744197
申请日：2024-06-14
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T2207/20081 , G06T2207/30041
摘要： A method and system for detecting a presence of comorbid ocular conditions. Input data that includes imaging data for an eye of a subject is received. A score that indicates whether a presence of a plurality of comorbid ocular conditions is detected is generated in the eye of the subject using a deep learning model and the input data. A comorbidity output is generated based on the score. The comorbidity score may be a classification indicating whether the presence of the plurality of comorbid ocular conditions is detected.
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公开(公告)号：US20240331877A1
公开(公告)日：2024-10-03
申请号：US18743437
申请日：2024-06-14
CPC分类号： G16H50/30 , G06T7/0012 , G06T7/10 , G16H10/20 , G16H10/60 , G16H20/10 , G16H50/20 , G06T2207/10101 , G06T2207/30041
摘要： A method and system for predicting fibrosis development. Optical coherence tomography (OCT) image data may be received for a retina of a subject with neovascular age-related macular degeneration (nAMD). The OCT image data is processed using a model system comprising a machine learning model to generate a prediction output. A final output is generated based on the prediction output in which the final output indicates a risk of developing fibrosis in the retina.
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公开(公告)号：US20240327837A1
公开(公告)日：2024-10-03
申请号：US18435935
申请日：2024-02-07
发明人： Congwei WANG , Christian WEILE , Martin EBELING , Lars JOENSON , Jonas VIKESAA , Ravi JAGASIA , Meiling LI
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/3231
摘要： The present invention relates to antisense oligonucleotides which are complementary to conserved TDP-43 binding sites on pre-mRNA transcripts, which are capable of restoring RNA binding protein function in the processing of multiple independent mRNAs in TDP-43 depleted cells.
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公开(公告)号：US20240318180A1
公开(公告)日：2024-09-26
申请号：US18735668
申请日：2024-06-06
发明人： Lars JOENSON , Bettina NORDBO , Jonas VIKESAA
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3233 , C12N2320/33
摘要： The present invention relates to antisense oligonucleotide splice modulators of actin-like 6B (ACTL6B). These antisense oligonucleotide splice modulators are complementary, such as fully complementary, to the ACTL6B precursor-mRNA, and are capable of increasing or restoring expression of ACTL6B in TDP-43 depleted cells, such as for use in conditions and medical indications where TDP-43 is functionally depleted.
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10.发明公开公开(公告)号：US20240317735A1
公开(公告)日：2024-09-26
申请号：US18016289
申请日：2021-07-12
发明人： Fabian DEY , Xiaoqing WANG , Zhisen ZHANG , Wei ZHU
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/5377 , A61K31/5386 , C07D519/00
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/5377 , A61K31/5386 , C07D519/00
摘要： The present invention relates to compounds of formula (I),
wherein R1, R2, R3a, R3b, R4, Q, Z and Y are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
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