公开(公告)号：US20220340597A1

公开(公告)日：2022-10-27

申请号：US17602057

申请日：2020-04-07

Applicant: Hoffmann-La Roche Inc.

Inventor： Wei ZHU ,  Zhiwei ZHANG ,  Zhisen ZHANG ,  Hong SHEN ,  Yongfu LIU ,  Yafei LIU ,  Haixia LIU ,  Buyu KOU ,  Fabian DEY ,  Lue DAI ,  Linuo ZHU

IPC: C07D519/00 ,  C07D487/04 ,  A61P37/06

Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3, n and A are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US20230041743A1

公开(公告)日：2023-02-09

申请号：US17780123

申请日：2020-11-24

Applicant: Hoffmann-La Roche Inc.

Inventor： Hong SHEN ,  Xiaoqing WANG ,  Hongtao XU ,  Zhisen ZHANG ,  Wei ZHU ,  Ge ZOU

IPC: C07D519/00

Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3, m and n are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US20230034723A1

公开(公告)日：2023-02-02

申请号：US17772930

申请日：2020-10-29

Applicant: Hoffmann-La Roche Inc.

Inventor： Hongtao XU ,  Zhisen ZHANG ,  Wei ZHU ,  Ge Zou

IPC: C07D487/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), wherein R1 and R3 and n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US20240317735A1

公开(公告)日：2024-09-26

申请号：US18016289

申请日：2021-07-12

Applicant: Hoffmann-La Roche Inc.

Inventor： Fabian DEY ,  Xiaoqing WANG ,  Zhisen ZHANG ,  Wei ZHU

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/4995 ,  A61K31/5377 ,  A61K31/5386 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/4995 ,  A61K31/5377 ,  A61K31/5386 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I),






wherein R1, R2, R3a, R3b, R4, Q, Z and Y are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US20230002415A1

公开(公告)日：2023-01-05

申请号：US17756221

申请日：2020-11-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Jianguo CHEN ,  Weixing ZHANG ,  Zhisen ZHANG ,  Wei ZHU

IPC: C07D519/00 ,  C07D491/107 ,  C07D491/147

Abstract: The present invention relates to compounds of formula (I), wherein R1, R3, Y and A are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.