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    Tricyclic compounds
    4.
    发明授权
    Tricyclic compounds 失效
    三环化合物

    公开(公告)号：US5155101A

    公开(公告)日：1992-10-13

    申请号：US612955

    申请日：1990-11-15

    Applicant: Yoshinari Sato ,  Teruaki Matuo ,  Takatomo Ogahara

    Inventor： Yoshinari Sato ,  Teruaki Matuo ,  Takatomo Ogahara

    IPC: C07D487/04 ,  A61K31/55 ,  A61K31/5513 ,  A61P1/00 ,  A61P1/08 ,  A61P1/14 ,  A61P1/16 ,  A61P5/00 ,  A61P43/00 ,  C07D471/04 ,  C07D471/06 ,  C07D487/06 ,  C07D491/06 ,  C07D498/06

    CPC classification number: C07D471/06 ,  C07D487/06

    Abstract: The invention relates to a compound of the formula: ##STR1## wherein R.sup.1 is aryl which may have suitable substituents(s), X is --O-- or ##STR2## in which R.sup.3 is hydrogen or lower alkyl, A is a bond or lower alkylene which may have lower alkyl group(s), andR.sup.2 is hydrogen; heterocyclic(lower)alkenoyl which may have carboxy or protected carboxy; heterocycliccarbonyl which may have N,N-di(lower)alkylamino(lower)alkyl, hydroxyimino(lower)alkyl, aryliminio(lower)alkyl, acyl or hydroxy(lower)alkylheterocyclic(lower)alkyl; aroyl which may have 1 to 3 substituent(s) selected from the group consisting of halogen, amino and mono(or di or tri)halo(lower)alkyl; arylcarbamoyl which may have halogen or lower alkoxy; arylamino(lower)alkanoyl; or ar(lower)alkanoyl which may have amino or protected amino,or a pharmaceutically acceptable salt thereof, useful as a cholecystokinin antagonist.

    Abstract translation: 本发明涉及下式的化合物：其中R 1为可具有合适取代基的芳基，X为-O-或其中R 3为氢或低级烷基，A为键或低级 可以具有低级烷基的亚烷基，并且R 2是氢; 可以具有羧基或被保护的羧基的杂环（低级）烯酰基; 可以具有N，N-二（低级）烷基氨基（低级）烷基，羟基亚氨基（低级）烷基，芳基亚氨基（低级）烷基，酰基或羟基（低级）烷基杂环（低级）烷基）的杂环羰基; 芳酰基，其可以具有1至3个选自卤素，氨基和单（或二或三）卤代（低级）烷基的取代基; 可以具有卤素或低级烷氧基的芳基氨基甲酰基; 芳基氨基（低级）烷酰基; 或可具有氨基或被保护的氨基的芳（低级）烷酰基或其药学上可接受的盐作为缩胆囊素拮抗剂。

    Pyridoindole derivatives and processes for preparation thereof
    5.
    发明授权
    Pyridoindole derivatives and processes for preparation thereof 失效
    吡啶并吲哚衍生物及其制备方法

    公开(公告)号：US5141945A

    公开(公告)日：1992-08-25

    申请号：US409744

    申请日：1989-09-20

    Applicant: Masayuki Kato ,  Kiyotaka Ito ,  Hisashi Takasugi

    Inventor： Masayuki Kato ,  Kiyotaka Ito ,  Hisashi Takasugi

    IPC: A61K31/435 ,  A61K31/44 ,  A61P1/00 ,  A61P1/04 ,  A61P25/04 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07D471/04

    CPC classification number: C07D471/04

    Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or lower alkenyl, R.sup.2 is hydrogen, lower alkyl, or halogen, R.sup.3 is imidazolyl or pyridyl, each of which may have suitable substituents, and R.sup.4 is hydrogen, lower alkyl, lower alkenyl or hydroxy (lower) alkyl and R.sup.5 is hydrogen, hydroxy, or alkanoyloxy, or R.sup.4 and R.sup.5 are linked together to form an additional bond or novel pyridoindole derivatives which are useful as potent in selective antagonists of 5-HT receptors.

    Abstract translation: 下式的化合物：其中R 1是氢，低级烷基或低级链烯基，R 2是氢，低级烷基或卤素，R 3是咪唑基或吡啶基，其各自可以具有合适的取代基，并且R 4是氢，低级烷基 ，低级链烯基或羟基（低级）烷基，R 5是氢，羟基或烷酰氧基，或者R 4和R 5连接在一起形成另外的键或新的吡啶并吲哚衍生物，其可用于5-HT受体的选择性拮抗剂。

    Bicyclic amine compound and a process for the preparation thereof
    6.
    发明授权
    Bicyclic amine compound and a process for the preparation thereof 失效
    双环胺化合物及其制备方法

    公开(公告)号：US5059608A

    公开(公告)日：1991-10-22

    申请号：US327813

    申请日：1989-03-23

    Applicant: Hisashi Takasugi ,  Atsushi Kuno ,  Mitsuru Ohkubo

    Inventor： Hisashi Takasugi ,  Atsushi Kuno ,  Mitsuru Ohkubo

    IPC: A61K31/47 ,  A61K31/472 ,  A61K31/55 ,  A61P25/00 ,  A61P25/08 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D217/10 ,  C07D217/14 ,  C07D217/16 ,  C07D223/16 ,  C07D401/06 ,  C07D405/04 ,  C07D409/04

    CPC classification number: C07D223/16 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D217/14 ,  C07D217/16 ,  C07D405/04 ,  C07D409/04 ,  Y02P20/55

    Abstract: The invention relates to a compound useful as an anticonvulsant, and for treatment of delayed neuronal death, the compound being a bicyclic amine of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.2 is aryl which may have one or more suitable substituent(s), cyclo(lower)alkyl or heterocyclic group,R.sup.3 is hydrogen, lower alkyl which may have one or more suitable substituent(s), lower alkenyl, or acyl which may have one or more suitable substituent(s),R.sup.4 is hydrogen, lower alkyl, or hydroxy(lower)alkyl,R.sup.5 is hydrogen, lower alkyl, halogen, or protected amino, andn is an integer of 1 or 2, with the proviso that when R.sup.3 is lower alkyl which may have one or more suitable substituent(s), R.sup.2 is cyclo(lower)alkyl or heterocyclic group,or a pharmaceutically acceptable salt thereof.

    Abstract translation: 本发明涉及可用作抗惊厥药并用于治疗延迟性神经元死亡的化合物，该化合物为下式的双环胺：其中R 1为低级烷基，R 2为可具有一个或多个合适取代基的芳基（ s），环（低级）烷基或杂环基，R 3是氢，可具有一个或多个合适取代基的低级烷基，可具有一个或多个合适取代基的低级烯基或酰基，R 4是氢 ，低级烷基或羟基（低级）烷基，R 5为氢，低级烷基，卤素或被保护的氨基，n为1或2的整数，条件是当R 3为低级烷基时，其可具有一个或多个合适的 取代基，R2是环（低级）烷基或杂环基，或其药学上可接受的盐。

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