公开(公告)号：US20100029595A1

公开(公告)日：2010-02-04

申请号：US12533537

申请日：2009-07-31

申请人： Jei Man RYU ,  Jin Soo LEE ,  Jae Hoon PARK ,  Yun-Ha HWANG ,  Duk Kyun CHUNG

发明人： Jei Man RYU ,  Jin Soo LEE ,  Jae Hoon PARK ,  Yun-Ha HWANG ,  Duk Kyun CHUNG

IPC分类号： A61K31/663 ,  A61P19/10

CPC分类号： A61K31/426 ,  A61K31/663 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, or salts thereof, and alendronic acid or a salt thereof.As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or salts thereof and alendronic acid or a salt thereof exhibits excellent inhibitory effect on osteoclast differentiation, as compared to each individual treatment, thereby being useful for the prevention or treatment of osteoporosis.

摘要翻译： 本发明涉及用于预防和治疗骨质疏松症的药物组合物，其包含N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} 苄脒，4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒或其盐，和阿仑膦酸或其盐。 作为骨质疏松症的预防或治疗组合物，将N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒的组合处理， 4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒或其盐和阿仑膦酸或其盐对破骨细胞表现出优异的抑制作用 与每个单独的治疗相比，可以用于预防或治疗骨质疏松症。

公开(公告)号：US20120093942A1

公开(公告)日：2012-04-19

申请号：US13334583

申请日：2011-12-22

申请人： Jei-Man RYU ,  Moon-Jung LEEM ,  Yang-Kook ROH ,  Hwan-Bong CHANG ,  Seong-Jun OH ,  Hyun-Yong LEE ,  Sae-Kwang KU ,  Hee-Bog YANG ,  Jung-Woo RHEE ,  Yun-Jung KIM ,  Joo Byoung YOON

发明人： Jei-Man RYU ,  Moon-Jung LEEM ,  Yang-Kook ROH ,  Hwan-Bong CHANG ,  Seong-Jun OH ,  Hyun-Yong LEE ,  Sae-Kwang KU ,  Hee-Bog YANG ,  Jung-Woo RHEE ,  Yun-Jung KIM ,  Joo Byoung YOON

IPC分类号： A61K36/488 ,  A61K35/64 ,  A61K36/25 ,  A61K36/605 ,  A61P13/12

CPC分类号： A61K36/25 ,  A61K36/488 ,  A61K36/60 ,  A61K2300/00

摘要： Disclosed is a pharmaceutical composition and health food comprising herb extracts of one or more herbs selected from the group consisting of Puerariae Radix, Bombycis corpus and Araliae Continentalis Radix. The herb medicine of this invention comprising a single or mixed composition may be useful for the prevention and treatment of renal diseases as well as improvement of renal functions.

摘要翻译： 公开了一种药物组合物和保健食品，其包含一种或多种选自由葛根，Bombycis语料库和Araliae Continentalis Radix组成的组的草药提取物。 包含单一或混合组合物的本发明药草可用于预防和治疗肾脏疾病以及改善肾功能。

公开(公告)号：US11028090B2

公开(公告)日：2021-06-08

申请号：US16480908

申请日：2018-01-25

申请人： Dong Wha Pharm. Co., Ltd. ,  Korea Research Institute of Chemical Technology

发明人： Kwangho Lee ,  Gildon Choi ,  Imran Ali ,  Joo Yun Lee ,  Jin Soo Lee ,  Whui Jung Park ,  Yong Tae Kim ,  Seung Hwan Kim ,  Jung Hwan Kim ,  Jae-Kyung Lim

IPC分类号： C07D487/04 ,  A61P35/00 ,  C07D519/00

摘要： Provided are a novel [1,2,4]triazolo[4,3-a]quinoxaline derivative, a method for preparing the same, and a pharmaceutical composition for preventing or treating bromodomain extra-terminal (BET) protein-related diseases including cancer and autoimmune diseases, containing the same as an active ingredient.

公开(公告)号：US20100029596A1

公开(公告)日：2010-02-04

申请号：US12533842

申请日：2009-07-31

申请人： Jei Man RYU ,  Jin Soo Lee ,  Yun-Ha Hwang ,  Young G. Jin ,  Ki Y. Kim

发明人： Jei Man RYU ,  Jin Soo Lee ,  Yun-Ha Hwang ,  Young G. Jin ,  Ki Y. Kim

IPC分类号： A61K31/6615 ,  A61P19/10

CPC分类号： A61K31/426 ,  A61K31/6615 ,  A61K31/663 ,  A61K2300/00

摘要： The present invention provides a method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivative or its salt, and bisphosphonate for the purpose of using simultaneously, separately, or sequentially as active ingredients. As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of the benzamidine derivative and the bisphosphonate compound exhibits excellent inhibitory effect on osteoclast differentiation than the total effect of each individual treatment, thereby being used for the prevention or treatment of osteoporosis.

摘要翻译： 本发明提供治疗或预防骨质疏松症的方法，包括向有需要的患者施用有效量的包含苯甲脒衍生物或其盐的药物组合物和双膦酸盐，以同时，单独或依次用作活性成分。 作为骨质疏松症的预防或治疗组合物，与单独治疗的总效果相比，苯甲脒衍生物和双膦酸化合物的组合治疗对破骨细胞分化表现出优异的抑制作用，从而用于预防或治疗骨质疏松症。

公开(公告)号：US20230143345A1

公开(公告)日：2023-05-11

申请号：US17917905

申请日：2021-03-19

申请人： DONG WHA PHARM. CO., LTD.

发明人： Joo Byoung YOON ,  Yun Ha HWANG ,  Ma Se LEE ,  Hyun Yong LEE

IPC分类号： A61K36/19 ,  A61K31/365 ,  A61P31/14 ,  A23L33/105 ,  A23L33/155 ,  A23L33/16 ,  A23L2/68

CPC分类号： A61K36/19 ,  A61K31/365 ,  A61P31/14 ,  A23L33/105 ,  A23L33/155 ,  A23L33/16 ,  A23L2/68 ,  A61K2236/33

摘要： The present invention relates to a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising an organic solvent extract of Justicia procumbens as an effective ingredient, a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising justicidin-A as an effective ingredient, a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising justicidin-B as an effective ingredient, or a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising 6′ hydroxyl justicidin-B as an effective ingredient, and a food composition thereof for preventing or ameliorating COVID-19 diseases. According to the present invention, an anhydrous ethanol extract of Justicia procumbens, justicidin-A, justicidin-B, and 6′ hydroxyl justicidin-B effectively inhibit SARS-CoV-2 virus, and thus may effectively prevent, treat, or ameliorate diseases caused by SARS-CoV-2 virus.

公开(公告)号：US10688143B2

公开(公告)日：2020-06-23

申请号：US15519116

申请日：2015-10-16

申请人： DONG WHA PHARM. CO., LTD.

发明人： Joo Byoung Yoon ,  Hyun Yong Lee ,  Ji Hyun Youm ,  Kwang Hyun Kim ,  Ji Hyun Jeon ,  Hwan Bong Chang ,  Yun Ha Hwang ,  Seung Kyoo Seong ,  Dong Rack Choi

IPC分类号： A61K36/19 ,  A61P11/02 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P27/14 ,  A61K8/9789 ,  A61P1/12 ,  A61Q19/00 ,  A23L33/105

摘要： The present invention relates to a pharmaceutical composition, food composition and cosmetic composition for preventing, treating, or improving allergic diseases comprising extract or fraction of a plant of the Justicia genus as an active ingredient. The extract or a fraction of a plant of the Justicia genus according to the present invention can inhibit IgE antibody secretion and the degranulation of mast cells and basophils, and exhibits an excellent anti-allergic effect, and thus can effectively prevent, treat, or improve allergic diseases.

公开(公告)号：US20190134126A1

公开(公告)日：2019-05-09

申请号：US16093829

申请日：2017-04-13

申请人： DONG WHA PHARM. CO., LTD.

发明人： Joo Byoung Yoon ,  Hyun Yong Lee ,  Ji Hyun Youm ,  Kwang Hyun Kim ,  Ji Hyun Jeon ,  Hwan Bong Chang ,  Ji Young Woo ,  Mi Hee Yoon ,  Min Soo Choi ,  Dong Rack Choi

IPC分类号： A61K36/19 ,  A61K31/36 ,  A61P11/00 ,  A23L33/105 ,  A61K9/00

摘要： The present invention relates to a pharmaceutical composition for preventing or treating respiratory disease, which comprises an alcohol or organic solvent extract of Justicia procumbens L. as an active ingredient, and to a pharmaceutical composition for preventing or treating respiratory disease, which comprises an alcohol or organic solvent extract of Justicia procumbens L., the extract comprising any one or more of justicidin A, justicidin B, justicidin C and phyllamyricin C, and also to a food composition for preventing or treating respiratory disease, which comprises the alcohol or organic solvent extract. The composition comprising the Justicia procumbens L. extract according to the present invention may inhibit abnormal overproliferation of splenocytes, may inhibit the secretion of allergic inflammatory cytokines, and exhibits an expectorant effect and an airway constriction inhibitory effect. Thus, it may effectively prevent, treat or improve respiratory disease.

公开(公告)号：US10172899B2

公开(公告)日：2019-01-08

申请号：US15795466

申请日：2017-10-27

申请人： DONG WHA PHARM. CO., LTD.

发明人： Da-Ae Park ,  Yoon-Young Chang ,  Kwang-Hyun Kim ,  Sang-Ho Lee ,  Chan-Seok Jeon ,  Hyun-Yong Lee

IPC分类号： A61K36/67 ,  A23L33/105 ,  A23L2/52 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48

摘要： The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.

公开(公告)号：US20180055902A1

公开(公告)日：2018-03-01

申请号：US15795466

申请日：2017-10-27

申请人： DONG WHA PHARM. CO., LTD.

发明人： Da-Ae PARK ,  Yoon-Young CHANG ,  Kwang-Hyun KIM ,  Sang-Ho LEE ,  Chan-Seok JEON ,  Hyun-Yong LEE

IPC分类号： A61K36/67 ,  A61K9/48 ,  A23L2/52 ,  A61K9/00 ,  A61K9/20

CPC分类号： A61K36/67 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/20 ,  A61K9/48 ,  A61K2236/17 ,  A61K2236/331 ,  A61K2236/333 ,  A61K2236/35 ,  A61K2236/53 ,  A61K2236/55

摘要： The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.

公开(公告)号：US20160346307A1

公开(公告)日：2016-12-01

申请号：US15116591

申请日：2014-11-25

申请人： DONG WHA PHARM. CO., LTD.

发明人： You Sun KIM ,  Gi Bang KOO ,  Jung Ho YUN ,  Woo Jung KIM ,  Yu Na JO

IPC分类号： A61K31/706 ,  C12Q1/68 ,  A61K31/337 ,  G01N33/50 ,  A61K31/704 ,  A61K31/7048

CPC分类号： A61K31/706 ,  A61K31/337 ,  A61K31/704 ,  A61K31/7048 ,  A61K45/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N2333/91205 ,  G01N2333/9121 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical composition for an anticancer adjuvant containing a receptor-interacting protein kinase-3 (RIP3) protein expression inducing agent or activator as an active ingredient. The present invention also provides a method for enhancing cancer cell death, comprising administering a RIP3 protein expression inducing agent or activator in combination with an anticancer drug to cancer cells. Additionally, the present invention relates to a method for screening an anticancer adjuvant which enhances anticancer drug sensitivity by promoting RIP3 expression; and a method for monitoring anticancer drug sensitivity based on RIP3 expression. Therefore, in the case of patients lacking RIP3 expression, the use of a conventional chemotherapeutic agent after inducing RIP3 expression by pretreatment with a demethylating agent may be an effective therapeutic strategy. Also, it is expected that monitoring anticancer drug sensitivity and screening an anticancer adjuvant that enhances anticancer drug sensitivity in anticancer therapy may be an effective strategy.

摘要翻译： 本发明涉及含有受体相互作用蛋白激酶-3（RIP3）蛋白表达诱导剂或活化剂作为活性成分的抗癌佐剂药物组合物。 本发明还提供了一种增强癌细胞死亡的方法，包括将RIP3蛋白表达诱导剂或活化剂与抗癌药联合施用于癌细胞。 另外本发明涉及通过促进RIP3表达来增强抗癌药物敏感性的抗癌佐剂的筛选方法。 以及基于RIP3表达监测抗癌药物敏感性的方法。 因此，在缺乏RIP3表达的患者的情况下，通过用去甲基化剂预处理诱导RIP3表达后使用常规化学治疗剂可能是有效的治疗策略。 此外，预期在抗癌治疗中监测抗癌药物敏感性和筛选增强抗癌药物敏感性的抗癌佐剂可能是有效的策略。