公开(公告)号：US20250025435A1

公开(公告)日：2025-01-23

申请号：US18702196

申请日：2022-10-25

Applicant: DOMPE' FARMACEUTICI SPA

Inventor： Andrea ARAMINI ,  Gianluca BIANCHINI ,  Samuele LILLINI ,  Mara TOMASSETTI ,  Laura BRANDOLINI

IPC: A61K31/192 ,  A61K9/14 ,  A61K31/195 ,  A61K31/198 ,  A61P29/00

Abstract: The present invention relates to new co-crystals of non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the class of phenylpropionic or phenylacetic acid derivatives. Lysine and Gabapentin, to their pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and/or inflammation.

公开(公告)号：US20240424060A1

公开(公告)日：2024-12-26

申请号：US18763519

申请日：2024-07-03

Applicant: DOMPE' FARMACEUTICI SPA

Inventor： Andrea ARAMINI ,  Pier Giorgio AMENDOLA ,  Anna SIRICO ,  Gaetano D'ANNIBALLE ,  Franca CATTANI ,  Marcello ALLEGRETTI ,  Flavio MANTELLI

IPC: A61K38/18 ,  A61P27/02

Abstract: The present invention relates to the field of treatment of ocular pathologies by administration of a NGF, which comprises more than 50% by weight of the NGF isoform of SEQ ID NO: 1. Said NGF is particularly useful in the treatment of ocular pathologies where the proliferation and survival effect of NGF is desired and where the proapoptotic effect of p75NTR is detrimental.

公开(公告)号：US20230390156A1

公开(公告)日：2023-12-07

申请号：US18034252

申请日：2021-10-27

Applicant: Dompe' Farmaceutici SpA

Inventor： Marcello ALLEGRETTI ,  Lucia APPARENTE ,  Marco Maria GENTILE ,  Simone MATTIOLI

IPC: A61J1/14 ,  A61K38/18

CPC classification number: A61J1/1468 ,  A61K38/185

Abstract: The present invention relates to a pharmaceutical package comprising a plastic container and an aqueous formulations of nerve growth factor (NGF), in which at least the surface of the container in contact with the NGF aqueous formulation is made of particular polypropylenes (PPs), characterized by certain thermal properties and crystallinity. Advantageously said containers show a NGF adhesion significantly lower than that of siliconized glass or of other polypropylenes. It is thus possible to store aqueous formulations of NGF in less severe conditions, avoiding additional coating treatments to the containers and additives while keeping the NGF titer constant.

公开(公告)号：US5808069A

公开(公告)日：1998-09-15

申请号：US513842

申请日：1995-10-31

Applicant: Enrico Bosone ,  Gaetano Clavenna ,  Carmelo Gandolfi ,  Marco Mantovanini ,  Roberto Curti

Inventor： Enrico Bosone ,  Gaetano Clavenna ,  Carmelo Gandolfi ,  Marco Mantovanini ,  Roberto Curti

IPC: A61K31/19 ,  C07C59/84 ,  C07C229/26 ,  C07C279/14 ,  C07D295/088 ,  C07D295/08

CPC classification number: C07D295/088 ,  A61K31/19 ,  C07C229/26 ,  C07C279/14 ,  C07C59/84

Abstract: The salts of S(+) 2-(3-benzoylphenyl)propionic acid and of R(-) 2-(3-benzoylphenyl)propionic acid with an organic base such as D-lysine, L-lysine, L-arginine, (R) 3-(4-phenylpiperazin-1-yl)propane-1,2-diol and (S) 3-(4-phenylpiperazin-1-yl)propane-1,2-diol, the process for their preparation and the corresponding pharmaceutical compositions containing said salts are described.

Abstract translation: PCT No.PCT / IT94 / 00020 Sec。 371日期1995年10月31日 102（e）日期1995年10月31日PCT 1994年3月7日PCT公布。 公开号WO94 / 20449 日期1994年9月15日S（+）2-（3-苯甲酰基苯基）丙酸和R（ - ）2-（3-苯甲酰基苯基）丙酸与有机碱如D-赖氨酸，L-赖氨酸， L-精氨酸，（R）3-（4-苯基哌嗪-1-基）丙烷-1,2-二醇和（S）3-（4-苯基哌嗪-1-基）丙烷-1,2-二醇，该方法 描述了它们的制备方法和含有所述盐的相应药物组合物。

公开(公告)号：US3732295A

公开(公告)日：1973-05-08

申请号：US3732295D

申请日：1970-01-28

Applicant: DOMPE FARMACEUTICI SPA

Inventor： DOMPE F

IPC: C07C233/12 ,  C07C103/12

CPC classification number: C07C233/12

Abstract: TRIMETHOXYBENZOYL-AMINOALKANOIC ACIDS OF GENERAL FORMULA

1,2,3-TRI(CH3-O-),5-(HOOC-(CH2)X-CH(-R)-NH-CO-)BENZENE

WHEREIN X IS AN INTEGER FROM 1 TO 5 AND R IS AN ALKYL GROUP HAVING 1 TO 3 CARBON ATOMS AND THEIR DERIVATIVES ARE PREPARED BY REACTING 3,4,5-TRIMETHOXYBENZOIC ACID CHLORIDE WITH AN AMINOALKANOIC ACID AT A TEMPERATURE BETWEEN -5 AND +5*C. THE COMPOUNDS ARE USEFUL IN THE TREATMENT OF HEART INFARCT.

公开(公告)号：US20230233543A1

公开(公告)日：2023-07-27

申请号：US17923420

申请日：2021-05-06

Applicant: Dompe' Farmaceutici SPA ,  FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  KATHOLIEKE UNIVERSITEIT LEUVEN - KU LEUVEN R&D

Inventor： Andrea Rosario BECCARI ,  Candida MANELFI ,  Carmine TALARICO ,  Andrea ZALIANI ,  Gerd GEISSLINGER ,  Philip GRIBBON ,  Pieter LEYSSEN

IPC: A61K31/4535 ,  A61K31/473 ,  A61P31/14

CPC classification number: A61K31/4535 ,  A61K31/473 ,  A61P31/14

Abstract: The present invention relates to compounds that are able to inhibt functional proteins of COVID-19 virus, SARS-Cov-2.

公开(公告)号：US5436262A

公开(公告)日：1995-07-25

申请号：US243627

申请日：1994-05-16

Applicant: Marco Mantovanini ,  Roberto Curti

Inventor： Marco Mantovanini ,  Roberto Curti

IPC: A61K31/415 ,  A61K31/4184 ,  A61P37/08 ,  C07D235/14 ,  C07D405/04 ,  C07D407/04 ,  C07D407/14

CPC classification number: C07D235/14

Abstract: Derivatives of 2-(benzimidazol-2-yl)-1,3-diaminopropane, the process for their preparation as well as the pharmaceutical compositions containing them as active ingredients are described. The compounds exhibit anti-allergic activity.

Abstract translation: 描述2-（苯并咪唑-2-基）-1,3-二氨基丙烷的衍生物，其制备方法以及含有它们作为活性成分的药物组合物。 该化合物表现出抗过敏​​活性。

公开(公告)号：US20240180889A1

公开(公告)日：2024-06-06

申请号：US18284951

申请日：2022-03-31

Applicant: Dompe' farmaceutici SpA

Inventor： Marcello ALLEGRETTI ,  Andrea Rosario BECCARI ,  Maria Candida CESTA ,  Elisabetta Maria Ester MAURI ,  Carmine TALARICO

IPC: A61K31/4535 ,  A61K39/00 ,  A61K39/215

CPC classification number: A61K31/4535 ,  A61K39/215 ,  A61K2039/53

Abstract: The present invention relates to the combination of a Selective Estrogen Receptor Modulator (SERM) and a COVID-19 vaccine.

公开(公告)号：US20240180888A1

公开(公告)日：2024-06-06

申请号：US18282357

申请日：2022-03-17

Applicant: Dompe' Farmaceutici SPA

Inventor： Marcello ALLEGRETTI ,  Andrea ARAMINI ,  Piergiorgio AMENDOLA ,  Laura BRANDOLINI ,  Maria Candida CESTA ,  Anna SIRICO

IPC: A61K31/451 ,  A61K31/427 ,  A61K39/00 ,  A61P37/08 ,  C07K16/28

CPC classification number: A61K31/451 ,  A61K31/427 ,  A61P37/08 ,  C07K16/2896 ,  A61K2039/505 ,  C07K2317/76

Abstract: The present invention relates to the use of a C5aR1 inhibitor for the prevention or treatment of a hypersensitivity reaction (HSR) to a taxane in an individual.

公开(公告)号：US20230357121A1

公开(公告)日：2023-11-09

申请号：US17922999

申请日：2021-05-04

Applicant: DOMPE' FARMACEUTICI SPA

Inventor： Andrea ARAMINI ,  Marcello ALLEGRETTI ,  Gianluca BIANCHINI ,  Samuele LILLINI ,  Mara TOMASSETTI

IPC: C07C59/84 ,  C07C229/26 ,  C07C229/28

CPC classification number: C07C59/84 ,  C07C229/26 ,  C07C229/28 ,  C07C2601/14 ,  C07B2200/13

Abstract: The present invention relates to a new co-crystal of Ketoprofen, Lysine and Gabapentin, to pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and/or inflammation.