Invention Publication
- Patent Title: PHARMACEUTICAL PACKAGES COMPRISING POLYPROPYLENE CONTAINERS AND NGF AQUEOUS FORMULATIONS PACKAGED THEREIN
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Application No.: US18034252Application Date: 2021-10-27
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Publication No.: US20230390156A1Publication Date: 2023-12-07
- Inventor: Marcello ALLEGRETTI , Lucia APPARENTE , Marco Maria GENTILE , Simone MATTIOLI
- Applicant: Dompe' Farmaceutici SpA
- Applicant Address: IT Milano
- Assignee: Dompe' Farmaceutici SpA
- Current Assignee: Dompe' Farmaceutici SpA
- Current Assignee Address: IT Milano
- Priority: EP 204487.1 2020.10.28
- International Application: PCT/EP2021/079879 2021.10.27
- Date entered country: 2023-04-27
- Main IPC: A61J1/14
- IPC: A61J1/14 ; A61K38/18

Abstract:
The present invention relates to a pharmaceutical package comprising a plastic container and an aqueous formulations of nerve growth factor (NGF), in which at least the surface of the container in contact with the NGF aqueous formulation is made of particular polypropylenes (PPs), characterized by certain thermal properties and crystallinity. Advantageously said containers show a NGF adhesion significantly lower than that of siliconized glass or of other polypropylenes. It is thus possible to store aqueous formulations of NGF in less severe conditions, avoiding additional coating treatments to the containers and additives while keeping the NGF titer constant.
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