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公开(公告)号：US11488088B2
公开(公告)日：2022-11-01
申请号：US17164990
申请日：2021-02-02
发明人： Paul Glavina , Jody Ann Tirinato , Pierre Emeric , Dan Molloy , Maureen Weber , Christopher Fetters
摘要： The present invention relates to a method and system for quality compliance, system and operator verification, and process management for point of care biological sample testing systems used in hospitals and other medical delivery environments. Specifically, the present invention may be directed to a computing device configured to generate a plurality of attributes configured to assess a competency level of an operator to operate at least one sample testing instrument, obtain operator derived data pertaining to the operator's ability to operate the at least one sample testing instrument, and determine a competency level of the operator for the at least one sample testing instrument based the plurality of attributes and the operator derived data.
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2.发明申请公开(公告)号：US20220003790A1
公开(公告)日：2022-01-06
申请号：US17475570
申请日：2021-09-15
发明人： Tian-Xian Zhao , Anjulia Chiu-Yuk Wong , Glenn Brian Martin , Katrina Petronilla Di Tullio , Isabelle Louisette Thibodeau , Steven Roy Breeze , Smitha RK Sutrala , Eric Hong , Jay Kendall Taylor , Sheila Diane Ball
IPC分类号： G01N33/86 , G01N33/49 , B01L3/00 , G01N27/403 , G01N27/416
摘要： The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.
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公开(公告)号：US11156607B2
公开(公告)日：2021-10-26
申请号：US15836216
申请日：2017-12-08
发明人： Jing Hua Hu , Antti Leo Oskari Virtanen , John Wilfrid Bezaire , Eric Edward Potter , James T. K. Smith , Cary James Miller , John Lewis Emerson Campbell , Adam Roger Moss
IPC分类号： G01N33/543 , G01N33/68 , G01N33/536 , G01N27/327 , G01R33/12 , B01L3/00 , G01N33/53 , G01N33/50 , G01N27/74
摘要： The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a housing, a heterogeneous surface capture immunosensor within the housing and configured to generate a first signal indicative of the concentration of the analyte in an upper concentration range, and a homogeneous magnetic bead capture immunosensor within the housing and configured to generate a second signal indicative of the concentration of the analyte in a lower concentration range.
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公开(公告)号：US20210310978A1
公开(公告)日：2021-10-07
申请号：US17350426
申请日：2021-06-17
发明人： Michael Louie LOW , Barry Bass , Sergey Gershtein
摘要： This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).
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公开(公告)号：US11060994B2
公开(公告)日：2021-07-13
申请号：US16104204
申请日：2018-08-17
发明人： Michael Louie Low , Barry Bass , Sergey Gershtein
IPC分类号： G01N27/327 , B01L3/00 , G01N21/31 , G01N27/27 , G01N21/77 , G01N33/48 , G01N27/07 , G01N27/416
摘要： This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).
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公开(公告)号：US20210162418A1
公开(公告)日：2021-06-03
申请号：US17166215
申请日：2021-02-03
发明人： Gary J. Vandersleen , Sergey Gershtein , Mitchell Tilson , Jaymin Patel , Craig H. Schneider , Seth Hunter , Paul Wasserman , Pierre Emeric
摘要： The invention relates to a thermal control system for controlling the temperature of a fluid. In particular, the invention relates to a control system having at least two heating elements, at least one of which is used for directly or indirectly heating a fluid, and at least one of which is used for heating a thermal probe used to determine the temperature of the fluid. The heating systems are controlled by at least one feedback controller.
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公开(公告)号：US20210156852A1
公开(公告)日：2021-05-27
申请号：US17165282
申请日：2021-02-02
IPC分类号： G01N33/543 , G01N33/539 , G01N27/74 , G01N33/68
摘要： The present invention relates to methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a method includes forming, in a biological sample, a first complex of signal antibodies and analyte, and a second complex of the first complex and capture antibodies immobilized on magnetic beads, and contacting a first immunosensor with the biological sample to form a third complex localized on or near a surface of the first immunosensor. The first immunosensor includes an immobilized layer of capture antibodies configured to bind to the analyte, and the third complex includes the first complex bound to the immobilized layer of capture antibodies. The method further includes contacting a magnetic field localized around a second immunosensor with the biological sample such that the second complex is localized on or near a surface of the second immunosensor.
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公开(公告)号：US11002747B2
公开(公告)日：2021-05-11
申请号：US15145899
申请日：2016-05-04
发明人： Paul Glavina , Jody Ann Tirinato
摘要： The present invention relates to systems and methods of determining quality compliance for one or more biological sample testing instruments used with one or more type of single-use blood testing cartridge, at the point-of-care in a hospital, or other location that deliver medical care. In particular, the systems and methods ensure that only instruments that pass a quality assurance protocol are used for point-of-care testing.
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公开(公告)号：US10981172B2
公开(公告)日：2021-04-20
申请号：US14206547
申请日：2014-03-12
发明人： Gary J. Vandersleen , Sergey Gershtein , Mitchell Tilson , Jaymin Patel , Craig H. Schneider , Seth Hunter , Paul Wasserman , Pierre Emeric
摘要： The invention relates to a thermal control system for controlling the temperature of a fluid. In particular, the invention relates to a control system having at least two heating elements, at least one of which is used for directly or indirectly heating a fluid, and at least one of which is used for heating a thermal probe used to determine the temperature of the fluid. The heating systems are controlled by at least one feedback controller.
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公开(公告)号：US10598675B2
公开(公告)日：2020-03-24
申请号：US16150818
申请日：2018-10-03
IPC分类号： G01N33/86 , G01N31/00 , B01L3/00 , G01N33/49 , G01N27/403 , G01N27/416
摘要： The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor.
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