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    Time-of-flight mass spectrometer and program
    81.
    发明授权
    Time-of-flight mass spectrometer and program 有权

    公开(公告)号：US11361957B2

    公开(公告)日：2022-06-14

    申请号：US16532630

    申请日：2019-08-06

    Applicant: SHIMADZU CORPORATION

    Inventor： Hideaki Izumi

    IPC: H01J49/40 ,  H01J49/06 ,  H01J49/42

    Abstract: A time-of-flight mass spectrometer includes a flight tube, an ion introduction unit that is connected to the flight tube, an ion detector that detects an ion flown in the flight tube, and a control unit that controls the ion introduction unit and the flight tube, wherein: the control unit sequentially changes an accumulation state of the ion to be introduced into the flight tube by the ion introduction unit, for a plurality of measurement processes performed repeatedly.

    ION ANALYZER
    82.
    发明申请
    ION ANALYZER 有权

    公开(公告)号：US20220157586A1

    公开(公告)日：2022-05-19

    申请号：US17599136

    申请日：2019-04-02

    Applicant: SHIMADZU CORPORATION ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

    Inventor： Hidenori TAKAHASHI ,  Daiki ASAKAWA

    IPC: H01J49/00 ,  H01J49/06

    Abstract: An ion analyzer includes a reaction chamber into which precursor ions derived from a sample component are introduced, a radical irradiation unit that generates and emits a predetermined type of radicals, a standard substance supply unit that individually supplies kinds of standard substances to the reaction chamber, where activation energy of radical addition reaction is known for each of the kinds of standard substances, and the activation energies are different in magnitude, an ion measurement unit that measures an amount of predetermined product ions generated from precursor ions derived from the standard substance by irradiation with the radicals, and a radical temperature calculation unit that obtains an amount of radicals that caused the radical addition reaction from the amount of the predetermined product ions and obtains a radical temperature based on a relationship between the amount of the radicals obtained for each kind of standard substance and activation energy.

    A System and Method to Conduct Correlated Chemical Mapping
    83.
    发明申请
    A System and Method to Conduct Correlated Chemical Mapping 有权

    公开(公告)号：US20220148866A1

    公开(公告)日：2022-05-12

    申请号：US17427300

    申请日：2020-02-03

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Thomas R. Covey ,  Chang Liu ,  Gary J. Van Berkel

    IPC: H01J49/00 ,  H01J49/04 ,  H01J49/06

    Abstract: A method for the repeated analysis of a sample bearing location. The sample bearing location may include, for instance, a sampled point in a tissue slice that is spatially and temporally correlated to the original slice. The slice may be in whole, or in part, a complete item or a portion of a complete item such as, for example, a human organ. The method improves the analysis process, such as mass spectrometry analysis, by providing a much more complete characterization of the target. The method also allows for the splitting of the sample and chemical/physical alteration of the aliquots for enhanced chemical analysis.

    Methods in mass spectrometry using collision gas as ion source
    84.
    发明授权
    Methods in mass spectrometry using collision gas as ion source 有权

    公开(公告)号：US11328915B2

    公开(公告)日：2022-05-10

    申请号：US16857117

    申请日：2020-04-23

    Applicant: Thermo Fisher Scientific GmbH

    Inventor： Johannes Schwieters ,  Henning Wehrs ,  Jamie Lewis

    IPC: H01J49/26 ,  H01J49/10 ,  H01J49/00 ,  H01J49/14 ,  H01J49/04 ,  H01J49/06 ,  H01J49/42

    Abstract: A mass spectrometry method comprising steps of generating an ion beam from an ion source; directing the ion beam into a collision cell; introducing into the collision cell through a gas inlet on the collision cell a charge-neutral analyte gas or reaction gas; ionizing the analyte gas or reaction gas in the collision cell by means of collisions between the analyte gas or reaction gas and the ion beam; transmitting ions from the ionized analyte gas or reaction gas from the collision cell into a mass analyzer; and mass analyzing the transmitted ions of the ionized analyte or reaction gas. The methods can be applied in isotope ratio mass spectrometry to determine the isotope abundance or isotope ratio of a reaction gas used in mass shift reactions between the gas and sample ions, to determine a corrected isotope abundance or ratio of the sample ions.

    ELECTRODYNAMIC MASS ANALYSIS WITH RF BIASED ION SOURCE
    85.
    发明申请
    ELECTRODYNAMIC MASS ANALYSIS WITH RF BIASED ION SOURCE 有权

    公开(公告)号：US20220139691A1

    公开(公告)日：2022-05-05

    申请号：US17088443

    申请日：2020-11-03

    Applicant: Applied Materials, Inc.

    Inventor： Alexandre Likhanskii ,  Joseph C. Olson ,  Frank Sinclair ,  Peter F. Kurunczi

    IPC: H01J49/36 ,  H01J49/10 ,  H01J49/06

    Abstract: Provided herein are approaches for performing electrodynamic mass analysis with a radio frequency (RF) biased ion source to reduce ion beam energy spread. In some embodiments, a system may include an ion source including a power supply, the ion source operable to generate a plasma within a chamber housing, and an extraction power assembly including a first power supply and a second power supply electrically coupled with the chamber housing of the ion source, wherein the first power supply and the second power supply are operable to bias the chamber housing of the ion source with a time modulated voltage to extract an ion beam from the ion source. The system may further include an electrodynamic mass analysis (EDMA) assembly operable to receive the ion beam and perform mass analysis on the ion beam.

    INTEGRATED LOW COST CURTAIN PLATE, ORIFICE PCB AND ION LENS ASSEMBLY
    87.
    发明申请
    INTEGRATED LOW COST CURTAIN PLATE, ORIFICE PCB AND ION LENS ASSEMBLY 有权

    公开(公告)号：US20220122829A1

    公开(公告)日：2022-04-21

    申请号：US17458218

    申请日：2021-08-26

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Aaron T. Booy

    IPC: H01J49/06 ,  H01J49/04 ,  H01J49/24 ,  H01J49/02

    Abstract: In one aspect, a curtain and orifice plate assembly for use in a mass spectrometry system is disclosed, which comprises a curtain plate including a first printed circuit board (PCB) having an aperture configured for receiving ions generated by an ion source of the mass spectrometry system and at least one gas-flow channel, where said first PCB has at least one metal coating disposed on at least a portion thereof. The assembly further includes an orifice plate coupled to the curtain plate, which includes a PCB providing an orifice that is substantially aligned with the aperture of the curtain plate so that the ions entering the assembly via said aperture of the curtain plate can exit the assembly via said orifice of the orifice plate, where the second PCB has at least one metal coating disposed on at least a portion thereof.

    APPARATUSES FOR OPTICAL AND MASS SPECTROMETRY DETECTION
    89.
    发明申请
    APPARATUSES FOR OPTICAL AND MASS SPECTROMETRY DETECTION 有权

    公开(公告)号：US20220102132A1

    公开(公告)日：2022-03-31

    申请号：US17545804

    申请日：2021-12-08

    Applicant: GMJ Technologies, Inc.

    Inventor： Oluwatosin O. Dada

    IPC: H01J49/16 ,  G01N27/447 ,  H01J49/02 ,  H01J49/06

    Abstract: Presented herein are apparatuses for use in capillary separations. An apparatus includes a coupling that integrates a capillary with a voltage source, a sheath liquid system, a fluid exit port, and a manifold. The coupling may be an elbow connector or equivalent. The manifold receives incident light from an incident light input, and emitted light is collected by a collected light output. The capillary enters the manifold at an input for the capillary, traverses the coupling, and terminates at the fluid exit port, for example an electrospray emitter. The capillary may also enter the manifold at an input for the capillary and terminates inside the manifold.

    ION GUIDE DEVICE AND ION GUIDE METHOD
    90.
    发明申请
    ION GUIDE DEVICE AND ION GUIDE METHOD 有权

    公开(公告)号：US20220102128A1

    公开(公告)日：2022-03-31

    申请号：US17393507

    申请日：2021-08-04

    Applicant: Shimadzu Corporation

    Inventor： Keke WANG ,  Xiaoqiang ZHANG ,  Wenjian SUN

    IPC: H01J49/06 ,  H01J49/02

    Abstract: An ion guide device includes a plurality of ring electrodes disposed in parallel, wherein each ring electrode includes at least 4 electrode units separated from each other, a channel for ion transmission is formed inside the plurality of ring electrodes, and an arrangement direction of the plurality of ring electrodes defines an axial direction of ion transmission; an radio-frequency voltage source, for applying out-of-phase radio-frequency voltages on the neighboring electrode units belonging to the same ring electrode, and applying in-phase radio frequency voltages on a neighboring electrode units along the axial direction, thereby forming an radio-frequency multipole field that confine ions in the ion guide device; and a direct-current voltage source, wherein the ions are transmitted off-axis and focused to a position closer to an inner surface of the ring electrode under a combined action of the radio-frequency voltage and the direct-current voltage.

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