公开(公告)号：US12180245B1

公开(公告)日：2024-12-31

申请号：US18395180

申请日：2023-12-22

Applicant: KING FAISAL UNIVERSITY

Inventor： Maged Elsayed Mohamed ,  Nancy Safwat Younis ,  Bandar Essa Eldubiab ,  Azza M. El Shafae ,  Nora Tawfeek ,  Eman Fikry

IPC: A61K36/185 ,  C07H1/08 ,  C07H17/07

Abstract: The disclosure of the present patent application relates generally to the separation and identification of myricetin-3-O-galactoside from Casuarina glauca Sieber branchlets.

公开(公告)号：US20230322838A1

公开(公告)日：2023-10-12

申请号：US18004468

申请日：2021-07-08

Applicant: LES LABORATOIRES SERVIER

Inventor： Bruno SCHIAVI ,  Philppe BESCOND ,  Patrick MOUCHET

IPC: C07H17/07 ,  C07H1/00

CPC classification number: C07H17/07 ,  C07H1/00

Abstract: Process for the preparation of diosmin.

公开(公告)号：US11248017B2

公开(公告)日：2022-02-15

申请号：US16622100

申请日：2018-06-11

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yong-Deog Hong ,  Jeong-Kee Kim

IPC: A61K36/82 ,  C07H17/07 ,  A61P29/00

Abstract: The present specification relates to an anti-inflammatory composition including a novel compound isolated from a post-fermented tea, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, and may be widely used in various areas related to anti-inflammation.

公开(公告)号：US20190225639A1

公开(公告)日：2019-07-25

申请号：US16373118

申请日：2019-04-02

Applicant: INTERQUIM, S.A.

Inventor： Francisco Javier LÓPEZ CREMADES

IPC: C07H17/07 ,  C07H1/00

Abstract: Provided is a process for the preparation of diosmin from hesperidin. The process involves the oxidation of acylated hesperidin with iodine or bromine in a C2-C4 carboxylic acid medium and subsequent treatment with an inorganic base to partially neutralize the acidic media. The process allows obtaining diosmin with low iodine or bromine content, avoiding the use of organic solvents.

公开(公告)号：US08993749B2

公开(公告)日：2015-03-31

申请号：US12740331

申请日：2008-12-26

Applicant: Masanori Hiramitsu ,  Toshikazu Omori ,  Kenji Yamaguchi ,  Hiroaki Bessho

Inventor： Masanori Hiramitsu ,  Toshikazu Omori ,  Kenji Yamaguchi ,  Hiroaki Bessho

IPC: C07H1/06 ,  C07H1/08 ,  A01N43/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K8/49 ,  A61K36/752 ,  A61Q19/00 ,  C07H17/07

CPC classification number: A61K31/7048 ,  A61K8/498 ,  A61K36/752 ,  A61Q19/00 ,  C07H17/07

Abstract: A process for producing an eriocitrin-containing material comprises the steps of: preparing an eriocitrin-containing citrus extract from a citrus fruit using an extractant; and separating eriocitrin from the citrus extract. The step of separating eriocitrin from the citrus extract comprises the steps of: bringing the citrus extract into contact with a porous synthetic adsorption resin such that eriocitrin in the citrus extract is adsorbed on the porous synthetic adsorption resin, the porous synthetic adsorption resin comprising a phenol-formaldehyde resin as a main framework and having amino and phenolic hydroxyl groups; and eluting the eriocitrin adsorbed on the porous synthetic adsorption resin using an elution solvent.

Abstract translation: 一种用于产生含有黑色素的材料的方法包括以下步骤：使用提取剂从柑橘类水果制备含有黑色素的柑橘提取物; 并从柑橘提取物中分离出白藜芦醇。 从柑橘提取物中分离出白藜芦醇的步骤包括以下步骤：使柑橘提取物与多孔合成吸附树脂接触，使得柑橘提取物中的白藜芦醇吸附在多孔合成吸附树脂上，多孔合成吸附树脂包含苯酚 甲醛树脂为主要骨架，具有氨基和酚羟基; 并使用洗脱溶剂洗脱吸附在多孔合成吸附树脂上的白藜芦醇。

公开(公告)号：US20140364382A1

公开(公告)日：2014-12-11

申请号：US14229352

申请日：2014-03-28

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： In Wook Choi ,  Yong Kon Park ,  Yoon Sook Kim ,  Hee Don Choi ,  Ho Young Park

IPC: A61K31/7048 ,  C07H1/08 ,  A23L1/30 ,  A23C9/133 ,  A61K36/752 ,  C07H17/07

CPC classification number: A61K31/7048 ,  A23C9/133 ,  A23L33/105 ,  A61K36/752 ,  A61K2236/30 ,  C07H1/08 ,  C07H17/07

Abstract: The present invention relates to a pharmaceutical composition for treating liver diseases, containing a narirutin extract of citrus peel extract or narirutin as an active ingredient. The extract or narirutin decreases cholesterol levels and fat levels in liver tissue, and thus can be utilized as a composition or food for preventing and treating liver diseases. In addition, the present invention relates to a method for extracting narirutin from citrus peel, and a method for preparing citrus fermented milk using the same.

Abstract translation: 本发明涉及一种用于治疗肝病的药物组合物，其含有柑橘皮提取物或奈替瑞汀的纳利霉素提取物作为活性成分。 提取物或奈替瑞汀降低肝组织中的胆固醇水平和脂肪水平，因此可用作预防和治疗肝脏疾病的组合物或食物。 此外，本发明涉及一种从柑橘皮中提取奈鲁定的方法，以及使用其制备柑橘发酵乳的方法。

公开(公告)号：US20140341934A1

公开(公告)日：2014-11-20

申请号：US14451845

申请日：2014-08-05

Applicant: Universiteit Leiden

Inventor： Jacob van Spronsen ,  Geert-Jan Witkamp ,  Frank Hollman ,  Young Hae Choi ,  Robert Verpoorte

IPC: C09K3/00 ,  C07H17/07 ,  C07D311/62

CPC classification number: C09K3/00 ,  B01D11/0288 ,  B01D11/04 ,  C07D311/62 ,  C07H17/07

Abstract: The invention is directed to a process for extracting materials from biological material, which process is characterized in that the naturally occurring biological material is treated with an extractant consisting of a deep eutectic solvent of natural origin or a an ionic liquid of natural origin to produce a biological extract of natural origin dissolved in the said solvent or ionic liquid.

Abstract translation: 本发明涉及从生物材料中提取材料的方法，该方法的特征在于天然存在的生物材料用天然来源的深共晶溶剂或天然来源的离子液体组成的萃取剂处理，以产生 天然来源的生物提取物溶解在所述溶剂或离子液体中。

公开(公告)号：US20140288286A1

公开(公告)日：2014-09-25

申请号：US14296698

申请日：2014-06-05

Applicant: King Saud University

Inventor： Amani S. AWAAD ,  Reham Moustafa EL-MELIGY

IPC: C07H17/07 ,  C07D311/40

CPC classification number: A61K31/352 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/47 ,  A61K2236/30 ,  C07D311/40 ,  C07H17/07

Abstract: The present invention relates to methods to isolate flavonoids from Euphorbia cuneata, and a pharmaceutical composition comprising the flavonoids or the extracts or both of them for a use as anti-ulcer agent. The present invention further relates to a method to isolate a compound selected from the group consisting of 4′-methoxy-luteolin-7-O-rhamnoglucoside and/or aromadendrin from Euphorbia cuneata.

Abstract translation: 本发明涉及从大戟属中分离黄酮的方法，以及包含类黄酮或其提取物或它们两者用作抗溃疡剂的药物组合物。 本发明还涉及从大戟属中分离选自4'-甲氧基 - 木犀草素-7-O-鼠李糖苷和/或芳香苷的化合物的方法。

公开(公告)号：US20140107051A1

公开(公告)日：2014-04-17

申请号：US14107055

申请日：2013-12-16

Applicant: INSTYTUT FARMACEUTYCZNY

Inventor： Grzegorz GRYNKIEWICZ ,  Grzegorz WEGRZYN ,  Barbara SZECHNER ,  Wieslaw SZEJA ,  Anna TYLKI-SZYMANSKA ,  Alicja WEGRZYN ,  Joanna JAKOBKIEWICZ-BANECKA ,  Sylwia BARANSKA ,  Barbara CZARTORYSKA ,  Ewa PIOTROWSKA

IPC: A61K31/353 ,  C07H17/07 ,  C07D407/12 ,  C07D311/34

CPC classification number: A61K31/353 ,  A61K31/352 ,  C07D311/34 ,  C07D407/12 ,  C07H17/07

Abstract: A pharmaceutical composition including a pharmaceutically acceptable excipient; and a natural isoflavone of formula (I), a derivative thereof, or a pharmaceutically acceptable salt thereof, the natural isoflavone, the derivative thereof, or the pharmaceutically acceptable salt thereof being in a therapeutically effective amount for the treatment of mucopolysaccharidosis. A method of treatment of mucopolysaccharidosis, the method including administering to a patient in the need of such treatment—a therapeutically effective amount of a natural isoflavone of formula (I), a derivative thereof, or a pharmaceutically acceptable salt thereof.

Abstract translation: 包含药学上可接受的赋形剂的药物组合物; 和式（I）的天然异黄酮，其衍生物或其药学上可接受的盐，其用于治疗粘多糖贮积病的治疗有效量的天然异黄酮，其衍生物或其药学上可接受的盐。 一种治疗粘多糖贮积症的方法，所述方法包括对需要这种治疗的患者施用治疗有效量的式（I）的天然异黄酮，其衍生物或其药学上可接受的盐。

公开(公告)号：US20140033369A1

公开(公告)日：2014-01-30

申请号：US13979717

申请日：2012-01-11

Applicant: Yoshikazu Tanaka ,  Naoko Okitsu ,  Keisuke Matsui

Inventor： Yoshikazu Tanaka ,  Naoko Okitsu ,  Keisuke Matsui

IPC: C12N9/10 ,  C12N15/82 ,  C07H17/07 ,  C12P19/18

CPC classification number: C12N9/1048 ,  A23L33/18 ,  A61K8/606 ,  A61Q19/00 ,  C07H17/07 ,  C12N15/8245 ,  C12P19/18 ,  C12P19/46 ,  C12P19/60 ,  C12P19/605 ,  Y02P20/52

Abstract: Provided is a polynucleotide encoding a protein having an activity to transfer a sugar to the hydroxy groups at the 4′- and 7-positions of a flavone. The polynucleotide is selected from the group consisting of: (a) a polynucleotide which comprises a base sequence represented by SEQ ID NO: 1, 3, or 12; (b) a polynucleotide which hybridizes to a polynucleotide comprising a base sequence complementary to a base sequence represented by SEQ ID NO: 1, 3, or 12 under high stringency conditions, and encodes a protein having an activity to transfer a sugar to the hydroxy groups at the 4′- and 7-positions of a flavone; (c) a polynucleotide which encodes a protein comprising an amino acid sequence represented by SEQ ID NO: 2, 4, or 13; (d) a polynucleotide which encodes a protein comprising an amino acid sequence in which one or more amino acids have been deleted, substituted, inserted, and/or added in an amino acid sequence represented by SEQ ID NO: 2, 4, or 13 and having an activity to transfer a sugar to the hydroxy groups at the 4′- and 7-positions of a flavone; etc.

Abstract translation: 提供了编码具有将糖转移到黄酮的4'-和7位上的羟基的活性的蛋白质的多核苷酸。 所述多核苷酸选自：（a）包含由SEQ ID NO：1,3或12表示的碱基序列的多核苷酸; （b）在高度严格条件下与包含与SEQ ID NO：1,3或12表示的碱基序列互补的碱基序列的多核苷酸杂交的多核苷酸，并编码具有将糖转移到羟基的活性的蛋白质 在黄酮的4'-和7位上的基团; （c）编码包含SEQ ID NO：2,4或13所示氨基酸序列的蛋白质的多核苷酸; （d）编码包含氨基酸序列的蛋白质的多核苷酸，其中一个或多个氨基酸已被缺失，取代，插入和/或添加在由SEQ ID NO：2,4或13表示的氨基酸序列中 并且具有将糖转移到黄酮的4'-和7-位的羟基的活性; 等等