公开(公告)号：US20210301324A1

公开(公告)日：2021-09-30

申请号：US17270733

申请日：2019-08-23

Applicant: Repertoire Genesis Incorporation

Inventor： Ryuji Suzuki ,  Hiroyuki Sato

IPC: C12Q1/686 ,  C12N15/86 ,  G16B30/10 ,  C12Q1/6806 ,  C12Q1/6881 ,  C12P19/34

Abstract: The present disclosure provides a method for analyzing a functional subunit pair gene of a T cell receptor (TCR) or a B cell receptor (BCR). The present disclosure provides a method comprising: (1) a step for providing a nucleic acid sample containing a nucleic acid of a TCR or BCR from a cell expressing an activated TCR or BCR; (2) a step for determining the nucleic acid sequence of the functional pair gene of the TCR or the BCR; and (3) a step for calculating the frequency of appearance of each gene and combinations thereof on the basis of the determined nucleic sequences, and identifying a functional subunit pair gene of the TCR or the BCR.

公开(公告)号：US11124566B2

公开(公告)日：2021-09-21

申请号：US17032838

申请日：2020-09-25

Applicant: Ten Peaks LLC

Inventor： Sundar Srinivasan ,  Christina Chow

IPC: C12Q1/68 ,  C07H21/04 ,  C07K16/24 ,  C12Q1/686 ,  C12Q1/6827 ,  C12Q1/6881

Abstract: The present disclosure provides methods of treating a patient with infliximab or alternative therapies to reduce the risk of developing, and/or severity of, an adverse drug reaction such as drug-induced liver injury. The methods include identifying patients at risk for developing DILI by determining the presence or absence of one or more HLA alleles in the patients.

公开(公告)号：US20210277359A1

公开(公告)日：2021-09-09

申请号：US16973916

申请日：2019-07-01

Applicant: L'OREAL

Inventor： Valérie HAYDONT

IPC: C12N5/077 ,  C12Q1/6881

Abstract: The present invention relates to an in vitroprocess for preparing cell and tissue models comprising at least one step of culturing fibroblasts of the dermo-hypodermic junction; the models obtained and also the implementation thereof in processes for screening active agents that promote the differentiation of fibroblasts of the dermo-hypodermic junction into adipocyte, osteoblast and/or chondroblast cells.

公开(公告)号：US20210277081A1

公开(公告)日：2021-09-09

申请号：US17314629

申请日：2021-05-07

Applicant: IMMATICS BIOTECHNOLOGIES GMBH

Inventor： Andrea MAHR ,  Toni WEINSCHENK ,  Helen HOERZER ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH

IPC: C07K14/47 ,  C07K14/74 ,  A61K39/00 ,  C12N15/115 ,  C07K7/08 ,  C07K7/06 ,  C07K16/28 ,  C12N5/0783 ,  A61K35/17 ,  C07K16/30 ,  C12P21/02 ,  C12Q1/6881 ,  G01N33/569 ,  C07K14/82 ,  C07K16/32 ,  C12Q1/6886 ,  G01N33/574 ,  C07K14/705 ,  C07K16/18

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US11111536B2

公开(公告)日：2021-09-07

申请号：US16666449

申请日：2019-10-29

Applicant: ABION INC

Inventor： Yoon La Choi ,  Yun Su Lee

IPC: C12Q1/6881

Abstract: The present application relates to a detection kit for genotypes capable of confirming cross contamination that may occur in a banking process of a patient-derived xenograft model or cell-derived xenograft model and a method for determining cross contamination using the same. According to the present disclosure, it is possible to determine all of cross contamination of mouse related genes, have high detection sensitivity and specificity to be close to 100%, rapidly examine the contamination, and be very useful in predicting mouse contamination.
Therefore, according to the present disclosure, cross contamination of genes related with the human and the mouse is predicted in advance to be applied to evaluation of anticancer drug efficacy using a patient-derived xenograft model or cell-derived xenograft model and contribute to cell banks using the patient-derived xenograft model or cell-derived xenograft model, and as a result, the present disclosure is very useful in a medical industry.

公开(公告)号：US11071756B2

公开(公告)日：2021-07-27

申请号：US17116635

申请日：2020-12-09

Applicant: Immatics Biotechnologies GmbH

Inventor： Heiko Schuster ,  Janet Peper ,  Philipp Wagner ,  Hans-Georg Rammensee

IPC: A61K39/00 ,  A61K35/17 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/725 ,  C07K16/30 ,  C12N15/115 ,  C12P21/02 ,  C12Q1/6881 ,  C12Q1/6886 ,  G01N33/574

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US11053546B2

公开(公告)日：2021-07-06

申请号：US15737105

申请日：2016-07-13

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Jurgen Peter Lode Del Favero ,  Michaël Vyverman ,  Paul Vauterin

IPC: G16B20/00 ,  G16H50/20 ,  C12Q1/6881 ,  C12Q1/6827 ,  G16H10/40 ,  G01N33/49 ,  G01N33/68

Abstract: A method for estimating whether a female is pregnant, said method comprising measuring allele presences (D) for a plurality of genetic markers of at least one chromosome, different from the X and Y chromosome, in a sample of cell-free DNA from a potentially pregnant female; each allele presence representing the presence at a genetic marker of at least one of: a reference allele of maternal or foetal origin, and an alternative allele of maternal or foetal origin; based on said measured allele presences, determining a homozygous fraction (Fho) thereof which is associated with purely homozygous genetic markers; and estimating whether the female is pregnant based on said fraction.

公开(公告)号：US20210196806A1

公开(公告)日：2021-07-01

申请号：US17058128

申请日：2019-05-23

Applicant: Gritstone Oncology, Inc.

Inventor： Roman Yelensky ,  James Xin Sun ,  Michele Busby ,  Jennifer Busby ,  Brendan Bulik-Sullivan ,  Mojca Skoberne ,  Wade Blair ,  Karin Jooss

IPC: A61K39/00 ,  C07K14/47 ,  C07K14/74 ,  C12N15/86 ,  A61K9/51 ,  A61K39/395 ,  C12Q1/6881 ,  C12Q1/6886 ,  A61P35/00

Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.

公开(公告)号：US20210147935A1

公开(公告)日：2021-05-20

申请号：US17114912

申请日：2020-12-08

Applicant: CONEXIO GENOMICS PTY LTD

Inventor： David Charles Sayer ,  Dianne Desantis

IPC: C12Q1/6881 ,  C12Q1/6874 ,  A61K35/28 ,  A61L27/38

Abstract: The present invention relates to a method of genotyping highly polymorphic nucleic acid. In particular, the present disclosure relates to methods for genotyping highly polymorphic gene alleles, such as HLA alleles using high-throughput sequencing technology. More particularly, the present invention relates to a capture probe method that is suitable for identifying alleles in highly polymorphic gene by targeting capture probes to non-coding sequences.

公开(公告)号：US20210106623A1

公开(公告)日：2021-04-15

申请号：US17116635

申请日：2020-12-09

Applicant: Immatics Biotechnologies GmbH

Inventor： Heiko SCHUSTER ,  Janet PEPER ,  Philipp WAGNER ,  Hans-Georg RAMMENSEE

IPC: A61K35/17 ,  C07K14/47 ,  A61K39/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/725 ,  C07K16/30 ,  C12N15/115 ,  C12P21/02 ,  C12Q1/6881 ,  C12Q1/6886 ,  G01N33/574

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.