公开(公告)号：US3736332A

公开(公告)日：1973-05-29

申请号：US3736332D

申请日：1970-09-18

Applicant: PLIVA PHARM & CHEM WORKS

Inventor： BUTULA I

IPC: C10L1/232 ,  B01J23/00 ,  C07B61/00 ,  C07D231/56 ,  C08K5/34 ,  C08L7/00 ,  C08L21/00 ,  C23F11/14 ,  C07D49/18

CPC classification number: C07D231/56

Abstract: A METHOD FOR THE PREPARATION OF 4,5,6,7,-TETRAHYDROINDAZOLES OF THE FORMULA:

1-R1,3-R2,R3,R4-4,5,6,7-TETRAHYDROINDAZOLE, OR 2-R1,3-R2,

R3,R4-4,5,6,7-TETRAHYDROINDAZOLE

IN WHICH AN INDAZOLE OF THE GENERAL FORMULA: 1-R1,3-R2,R3,R4-INDAZOLE OR 2-R1,3-R2,R3,R4-INDAZOLE IS HYDROGENATED IN THE PRESENCE OF PALLADIUM, RHODIUM OR PLATINUM OR CATALYSTS CONTAINING MIXTURES OF THEM AND IN THE PRESENCE OF A STRONG ACID IN A MOLAR EQUIVALENT AT LEAST EQUAL TO THAT OF THE BASIC GROUPS.

公开(公告)号：US3729479A

公开(公告)日：1973-04-24

申请号：US3729479D

申请日：1971-05-06

Applicant: TENNECO CHEM

Inventor： MINIERI P

IPC: C07D231/56 ,  C07F9/24 ,  C07F9/6503 ,  C09D5/14 ,  C07D49/18

CPC classification number: C09D5/14 ,  C07D231/56 ,  C07F9/24 ,  C07F9/65032 ,  C07F9/65038

Abstract: COMPOUNDS THAT HAVE THE STRUCTURAL FORMULA 1-((R-)2-N-C(=NH)-S-CH2-),3-X,(Y)N-INDAZOLE . HA WHEREIN X REPRESENTS HYDROGEN OR HALOGEN, Y REPRESENTS HALOGEN OR NITRO, EACH REPRESENTS HYDROGEN OR A LOWER ALKYL GROUP, N REPRESENTS AIN INTEGER IN THE RANGE OF ZERO TO 2, AND A REPRESENTS THE ANION OF A STRONG ACID, ARE USED TO CONTROL THE GROWTH OF FUNGI. AMONG THE MOST ACTIVE OF THESE COMPOUNDS ARE 2-(5-NITROINDAZOLYL-N1METHYL)-2-THIOPSEUDOUREA HYDROCHLORIDE AND 2 - (3 - CHLORO - 6 - NITROINDAZOLY - (1 - METHYL) - 2 - THIOPSEUDOUREA HYDROCHLORIDE.

公开(公告)号：US3725432A

公开(公告)日：1973-04-03

申请号：US3725432D

申请日：1971-06-28

Applicant: NOM COLLECTIF SCIENCE UNION ET ,  FR MEDICALE SOC

Inventor： BEREGI L ,  HUGON P ,  LE DOUAREC J

IPC: C07D231/10 ,  C07D231/12 ,  C07D521/00 ,  C07D49/18

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: Pyrazole compounds of the formula

WHEREIN R1 and R2 are hydrogen, methyl or ethyl, B is

AND X is hydrogen or halogen. These compounds possess analgesic and anti-inflammatory properties.

Abstract translation: 式WHEREIN R 1和R 2的吡唑化合物是氢，甲基或乙基，B是AND X是氢或卤素。

公开(公告)号：US3707477A

公开(公告)日：1972-12-26

申请号：US3707477D

申请日：1970-09-10

Applicant: BOEHRINGER SOHN INGELHEIM

Inventor： OST WALTER ,  THOMAS KLAUS ,  JERCHEL DIETRICH

IPC: A61K31/16 ,  A01N35/08 ,  A01N37/26 ,  A01N43/48 ,  A61K31/19 ,  A61K31/21 ,  A61K31/275 ,  A61K31/395 ,  A61K31/535 ,  A61P31/00 ,  C07C233/00 ,  C07C233/02 ,  C07C233/36 ,  C07C233/38 ,  C07C233/78 ,  C07C235/10 ,  C07C235/20 ,  C07C255/24 ,  C07C255/58 ,  C07C331/12 ,  C07D203/12 ,  C07D213/74 ,  C07D213/79 ,  C07D217/04 ,  C07D221/22 ,  C07D223/14 ,  C07D227/04 ,  C07D231/06 ,  C07D231/12 ,  C07D233/06 ,  C07D233/16 ,  C07D233/56 ,  C07D233/95 ,  C07D249/08 ,  C07D249/18 ,  C07D265/06 ,  C07D265/30 ,  C07D295/02 ,  C07D295/10 ,  C07D295/12 ,  C07D295/13 ,  C07D295/215 ,  C07D295/22 ,  C07D295/28 ,  C07D405/12 ,  C07D521/00 ,  C07D49/18 ,  C07D49/36

CPC classification number: C07D213/74 ,  C07C255/00 ,  C07D203/12 ,  C07D217/04 ,  C07D231/12 ,  C07D233/06 ,  C07D233/16 ,  C07D233/56 ,  C07D233/95 ,  C07D249/08 ,  C07D249/18 ,  C07D295/13 ,  C07D295/215 ,  C07D295/30

Abstract: COMPOUNDS OF THE FORMULA

R1-CO-NH-CH(-R2)-CCL3

WHEREIN

R1 IS HYDROGEN; ALKYL OF 1 TO 17 CARBON ATOMS; MONO-, DI- OR TRI-HALO-SUBSTITUTED ALKYL OF 1 TO 17 CARBON ATOMS; ALKENYL OF 2 TO 17 CARBON ATOMS; ALKOXY OF 1 TO 2 CARBON ATOMS; PHENYL; 2,4-DICHLOROPHENOXYMETHYL; OR A-(2,4-DICHLOROPHENOXY)-ETHYL; AND R2 IS DISUBSTITUTED ACYCLIC AMINO OR OPTIONALLY SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLIC AMINO;

THE COMPOUNDS ARE USEFUL AS CONTACT OR SYSTEMIC BIOCIDAL OR BIOSTATIC AGENTS, ESPECIALLY AGAINST MILDEW AND VARIOUS OTHER FUNGI.

公开(公告)号：US3705175A

公开(公告)日：1972-12-05

申请号：US3705175D

申请日：1970-03-26

Applicant: EGYT GYOGYSZERVEGYESZETI GYAR

Inventor： MAGDANYI LASZLO ,  GELLERI ANDRAS ,  PALLOS LASZLO ,  ERDELYI LUJZA ,  GOROG PETER

IPC: C07D231/56 ,  C07D487/14 ,  C07D49/18

CPC classification number: C07D231/56 ,  C07D487/14 ,  Y10S514/91

Abstract: INDAZOLE-3-CARBOXYLIC AMIDES OF THE GENERAL FORMULA

1-Q,3-(R1-N(-R2)-CO-),5,6-DI(CH3-O-)-1H-INDAZOLE

WHEREIN R1 AND R2 REPRESENT INDEPENDENTLY HYDROGEN, STRAIGHT CHAINED OR BRANCHED ALKYL OF UP TO 16 CARBON ATOMS, CYCLOALKYL, NAPHTHYL, PHENYL OR ARALKYL GROUP, WHERE THE PHENYL AND ARALKYL GROUPS MAY BE SUBSTITUTED WITH ONE OR TWO LOWER ALKYL, ALKOXY, TRIFLUOROMETHYL OR HALO SUBSTITUENT, FURTHER R1 AND R2 MAY FORM TOGETHER WITH THE ADJACENT NITROGEN ATOM AND OPTIONALLY WITH A FURTHER NITROGEN ATOM A 5 OR 6 MEMBERED HETEROCYCLIC RADICAL, Q REPRESENTS HYDROGEN, ALKALI METAL OR AN ACYL GROUP OF 1 TO 4 CARBON ATOMS HAVE BEEN PREPARED. THE NEW COMPOUNDS POSSESS VALUABLE PHARMACOLOGICAL ACTIVITIES, FIRST ALL THEY ARE POTENT ANTI-INFLAMMATORY AND ANALGESIC AGENTS.

公开(公告)号：US3704242A

公开(公告)日：1972-11-28

申请号：US3704242D

申请日：1970-12-30

Applicant: AMERICAN HOME PROD

Inventor： SANTILLI ARTHUR A ,  KIM DONG H

IPC: C07D231/20 ,  C07D49/18

CPC classification number: C07D231/20 ,  Y10S514/924

Abstract: R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND (LOWER)ALKYL; R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROXY, AMINO AND (LOWER) ALKOXY; N IS A WHOLE INTEGER OF 1 OR 2. THE COMPOUNDS ARE ACTIVE AS INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS.

WHEREIN

PYRAZOLE
1-(R1-NH-C(=S)-),3-(CH3-),4-(R2-CO-(CH2)N-),5-(HO-)

NOVEL COMPOUNDS OF THE FORMULA

公开(公告)号：US3697540A

公开(公告)日：1972-10-10

申请号：US3697540D

申请日：1969-09-16

Applicant: FUJI PHOTO FILM CO LTD

Inventor： KIMURA SHIRO ,  ISHIGE SADAO ,  KOBAYASHI TERUO

IPC: B41M5/145 ,  B41M5/30 ,  B41M5/327 ,  C07D491/20 ,  C07D49/18

CPC classification number: C07D491/20 ,  B41M5/145 ,  B41M5/1455 ,  B41M5/327 ,  B41M5/3275

Abstract: Chromenopyrazol compounds having the formula

D R A W I N G

Abstract translation: 公开了具有式的色烯并吡唑化合物及其制备方法。 色酮化合物可用作压敏复印纸中的成色剂。

公开(公告)号：US3665008A

公开(公告)日：1972-05-23

申请号：US3665008D

申请日：1970-06-17

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL

IPC: C07D231/18 ,  C07D495/04 ,  C07D49/18

CPC classification number: C07D495/04 ,  C07D231/18

Abstract: 1,3-Disubstituted-5,6-dihydrothiopyrano(2,3-c) pyrazoles are synthesized from the new 3-((1,3-disubstituted-5pyrazolyl)thio)propionic acids described. The new fused-ring compounds have excellent anti-inflammatory activity; they relieve edemas and are also useful as antipyretics and analgesics.

公开(公告)号：US3649641A

公开(公告)日：1972-03-14

申请号：US3649641D

申请日：1969-11-04

Applicant: AMERICAN HOME PROD

Inventor： KIM DONG H ,  SANTILLI ARTHUR A

IPC: C07D231/18 ,  C07D49/18

CPC classification number: C07D231/18

Abstract: 4 - HYDROXY-1-SUBSTITUTED-1H-THIENO(2,3-C)-PYRAZOLE-5CARBOXYLIC ACID DERIVATIVES USEFUL AS ANTIAMEBIC AGENTS ARE DISCLOSED, AS WELL AS METHODS OF SYNTHESIS OF THESE COMPOUNDS.

公开(公告)号：US3647819A

公开(公告)日：1972-03-07

申请号：US3647819D

申请日：1969-09-19

Applicant: STERLING DRUG INC

Inventor： KIRCHNER FREDERICK K

IPC: C07D231/56 ,  C07D49/18

CPC classification number: C07D231/56

Abstract: A SERIES OF INDAZOLYLPHENYLUREAS AND INDAZOLYLPHENYLTHIOUREAS, USEFUL FOR PREVENTING AND SUPPRESSING COCCIDIOSIS IN POULTRY, ARE PREPARED BY THE CONDENSATION OF AN AMINOINDAZOLE AND A PHENYLISOCYANATE OR A PHENYLISOTHIOCYANATE.