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    Antibodies that are capable of specifically binding tissue factor pathway inhibitor
    81.
    发明授权
    Antibodies that are capable of specifically binding tissue factor pathway inhibitor 有权
    能够特异性结合组织因子途径抑制剂的抗体

    公开(公告)号：US09228022B2

    公开(公告)日：2016-01-05

    申请号：US13780631

    申请日：2013-02-28

    Applicant: Novo Nordisk A/S

    Inventor： Ida Hilden ,  Jes Thorn Clausen ,  Lars Christian Petersen ,  Brit Binow Soerensen ,  Helle Heibroch Petersen ,  Anders Svensson

    IPC: A61K39/00 ,  C07K16/38

    CPC classification number: C07K16/38 ,  C07K2317/34 ,  C07K2317/76

    Abstract: The invention relates to antibodies that are capable of specifically binding tissue factor pathway inhibitor (TFPI), neutralizing free TFPI and reducing the clotting time of blood. Furthermore, the invention relates to polynucleotides that encode such antibodies and to cells that comprise the polynucleotides or that express the antibodies of the invention. Such antibodies have utility in the treatment of subjects with a coagulopathy, alone as well as in combination with a second agent.

    Abstract translation: 本发明涉及能够特异性结合组织因子途径抑制剂（TFPI），中和游离TFPI并降低血液凝血时间的抗体。 此外，本发明涉及编码这种抗体的多核苷酸以及包含多核苷酸或表达本发明的抗体的细胞。 这样的抗体可用于治疗具有凝血病的受试者，单独和与第二药剂组合。

    Serpinf2-Binding Molecules and Method of Use Thereof
    86.
    发明申请
    Serpinf2-Binding Molecules and Method of Use Thereof 审中-公开
    Serpinf2结合分子及其使用方法

    公开(公告)号：US20140220034A1

    公开(公告)日：2014-08-07

    申请号：US14198804

    申请日：2014-03-06

    Applicant: Translational Sciences Inc.

    Inventor： Guy L. Reed

    IPC: C07K16/38

    CPC classification number: C07K16/38 ,  A61K2039/505 ,  C07K16/18

    Abstract: Compositions and methods of using SerpinF2-binding molecules for preventing and/or reducing organ damage, functional disability or mortality in a patient at risk due to the activity of SerpinF2 and/or plasminogen activators on tissue injury. Also provided are compositions and methods of using SerpinF2-binding molecules for inhibiting hemorrhage, edema, and apoptosis. Methods for the preparation of medicaments for such methods of treatment and prevention are provided.

    Abstract translation: 使用SerpinF2结合分子预防和/或减少由于SerpinF2和/或纤溶酶原激活物对组织损伤的活性而处于风险中的患者的器官损伤，功能障碍或死亡率的组合物和方法。 还提供了使用SerpinF2结合分子来抑制出血，水肿和凋亡的组合物和方法。 提供了用于制备用于这种治疗和预防方法的药物的方法。

    Shutter repair system
    87.
    发明授权
    Shutter repair system 有权
    快门修复系统

    公开(公告)号：US08783992B2

    公开(公告)日：2014-07-22

    申请号：US13948079

    申请日：2013-07-22

    Applicant: Ben Hoch ,  Michael Cerillo

    Inventor： Henry Golden

    IPC: F16D3/00

    CPC classification number: F16C11/04 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/38 ,  E06B7/086 ,  E06B9/0638 ,  E06B9/302 ,  F16B45/00 ,  Y10T403/32041 ,  Y10T403/32606 ,  Y10T403/33

    Abstract: A system is provided for joining two discrete devices together, such as a louver panel and a tilt rod, where the system comprises a first and second component, each comprising a link connected to a resilient sheet, with each component being independently adhered to one of the two discrete devices for joining the two devices in engaged but moveable relationship.

    Abstract translation: 提供了一种用于将两个分立装置连接在一起的系统，例如百叶窗板和倾斜杆，其中系统包括第一和第二部件，每个部件包括连接到弹性片的连杆，每个部件独立地粘附到 用于将两个装置接合但可移动的关系的两个分立装置。

    Methods and compositions for reducing amyloid beta levels
    88.
    发明授权
    Methods and compositions for reducing amyloid beta levels 有权
    降低淀粉样蛋白β水平的方法和组合物

    公开(公告)号：US08691519B2

    公开(公告)日：2014-04-08

    申请号：US13847092

    申请日：2013-03-19

    Applicant: The J. David Gladstone Institutes

    Inventor： Li Gan ,  Lennart Mucke

    IPC: C12Q1/37 ,  G01N33/53 ,  C12N9/50

    CPC classification number: C12Q1/37 ,  A61K31/7052 ,  A61K38/00 ,  A61K38/55 ,  A61K39/3955 ,  C07K16/38 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2330/51 ,  C12Q1/68 ,  G01N33/6896

    Abstract: The present invention provides methods for reducing the level of amyloid beta protein in a cell or tissue, the methods generally involving contacting the cell or tissue with an agent that reduces cystatin C levels and/or activity. The present invention provides methods for treating Alzheimer's disease (AD), and methods for treating cerebral angiopathy, in an individual, the methods generally involving administering to an individual having AD a therapeutically effective amount of an agent that reduces cystatin C levels and/or activity. The present invention further provides methods for identifying an agent that reduces cystatin C levels and/or activity.

    Abstract translation: 本发明提供降低细胞或组织中淀粉样蛋白β蛋白水平的方法，所述方法通常涉及使细胞或组织与降低半胱氨酸蛋白酶抑制剂C水平和/或活性的试剂接触。 本发明提供了治疗阿尔茨海默氏病（AD）的方法和个体治疗脑血管病的方法，通常涉及向患有AD的个体施用治疗有效量的减少半胱氨酸蛋白酶抑制剂C水平和/或活性的药物的方法 。 本发明进一步提供了用于鉴定降低半胱氨酸蛋白酶抑制剂C水平和/或活性的试剂的方法。

    Antibodies That Are Capable of Specifically Binding Tissue Factor Pathway Inhibitor
    90.
    发明申请
    Antibodies That Are Capable of Specifically Binding Tissue Factor Pathway Inhibitor 审中-公开
    能够特异性结合组织因子途径抑制剂的抗体

    公开(公告)号：US20130253173A1

    公开(公告)日：2013-09-26

    申请号：US13780631

    申请日：2013-02-28

    Applicant: NOVO NORDISK A/S

    Inventor： Ida Hilden ,  Jes Thorn Clausen ,  Lars Christian Petersen ,  Brit Binow Soerensen ,  Helle Heibroch Petersen ,  Anders Svensson

    IPC: C07K16/38

    CPC classification number: C07K16/38 ,  C07K2317/34 ,  C07K2317/76

    Abstract: The invention relates to antibodies that are capable of specifically binding tissue factor pathway inhibitor (TFPI), neutralising free TFPI and reducing the clotting time of blood. Furthermore, the invention relates to polynucleotides that encode such antibodies and to cells that comprise the polynucleotides or that express the antibodies of the invention. Such antibodies have utility in the treatment of subjects with a coagulopathy, alone as well as in combination with a second agent.

    Abstract translation: 本发明涉及能够特异性结合组织因子途径抑制剂（TFPI），中和游离TFPI并降低血液凝血时间的抗体。 此外，本发明涉及编码这种抗体的多核苷酸以及包含多核苷酸或表达本发明的抗体的细胞。 这样的抗体可用于治疗具有凝血病的受试者，单独和与第二药剂组合。

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