公开(公告)号：US20130302340A1

公开(公告)日：2013-11-14

申请号：US13852777

申请日：2013-03-28

Applicant: Bayer Healthcare LLC

Inventor： Clark Pan ,  Andreas M. Knorr ,  Michael Schauer ,  Claudia Hirth-Dietrich ,  Sabine Kraft ,  Barbara Krebs

IPC: C07K16/38

CPC classification number: C07K16/38 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/76

Abstract: Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.

Abstract translation: 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。

公开(公告)号：US20140086935A1

公开(公告)日：2014-03-27

申请号：US14090833

申请日：2013-11-26

Applicant: Bayer Healthcare LLC

Inventor： Clark Pan ,  Andreas M. Knorr ,  Michael Schauer ,  Claudia Hirth-Dietrich ,  Sabine Kraft ,  Barbara Krebs

IPC: C07K16/40

CPC classification number: C07K16/38 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/76

Abstract: Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.

Abstract translation: 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。