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81.发明授权公开(公告)号：US08071281B2
公开(公告)日：2011-12-06
申请号：US12930776
申请日：2011-02-07
申请人： Michael D. Cecchi
发明人： Michael D. Cecchi
CPC分类号： A01N1/0221 , A01N1/02
摘要： A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, antioxidants, fatty acids to supply the specimens with the chemical ingredients and uptake requirements required to recover and prosper during and after the cryopreservation process. The solution supplies nutrients to the specimens that will replenish depletion and damage to the specimens and their mitochondria, spindles and structural features, such as cell walls. One formulation addresses the additional requirements of frozen specimens as opposed to the current media solutions and methods which treat the un-frozen specimens the same as the frozen specimens when recovering them from cryopreservation.
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公开(公告)号：US20110281352A1
公开(公告)日：2011-11-17
申请号：US12597546
申请日：2008-04-28
申请人： Sten Raeder , Tor Paaske Utheim
发明人： Sten Raeder , Tor Paaske Utheim
CPC分类号： A01N1/02 , A01N1/0226 , A01N1/0263 , A61F2/14
摘要： A kit (1) for storing cells or tissues. The kit (1) comprises a frame (7) having an opening therein and a peripheral wall surrounding the opening. Also provided is a sealable receptacle (2) for receiving the frame (7) and for receiving a liquid medium (6). A section of the sealable receptacle (2) being formed of a resilient member (5) for permitting access to the interior of the receptacle (5) by a penetrating element and subsequently forming a seal after withdrawal of the penetrating element.
摘要翻译： 用于储存细胞或组织的试剂盒（1）。 套件（1）包括其中具有开口的框架（7）和围绕开口的周边壁。 还提供了用于容纳框架（7）并用于接收液体介质（6）的可密封的容器（2）。 可密封的容器（2）的一部分由弹性构件（5）形成，用于允许通过穿透元件进入容器（5）的内部，并且随后在抽出穿透元件之后形成密封。
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公开(公告)号：US08052667B2
公开(公告)日：2011-11-08
申请号：US11574857
申请日：2005-09-07
申请人： Keith Rosiello , Henrik Clausen
发明人： Keith Rosiello , Henrik Clausen
CPC分类号： A01N1/0226 , A01N1/00 , A01N1/02
摘要： The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
摘要翻译： 本发明提供具有降低的血小板清除率的改良血小板和减少血小板清除率的方法。 还提供了用于保存血小板的组合物。 本发明还提供了制备含有改性血小板的药物组合物和用于将哺乳动物给药以介导止血的方法。
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公开(公告)号：US20110252748A1
公开(公告)日：2011-10-20
申请号：US13167611
申请日：2011-06-23
申请人： Kazuki ISHIHARA , Hideaki MURAHASHI , Naomi NAKATANI , Yoshihiro YOSHIKAWA , Akio SHIRASU , Hidenori OZAKI
发明人： Kazuki ISHIHARA , Hideaki MURAHASHI , Naomi NAKATANI , Yoshihiro YOSHIKAWA , Akio SHIRASU , Hidenori OZAKI
CPC分类号： B32B27/34 , A01N1/02 , A01N1/0268 , A61J1/10 , A61J1/165 , A61M1/0272 , B32B27/32 , B65D81/18 , C08F214/18 , C08F214/26 , Y10T156/1002
摘要： A package for a cryopreservation container including at least an adhesive fluoropolymer film. The package for a cryopreservation container makes it possible to store blood, rare cells and vital tissues in a very low temperature environment without any damage to the container. Further, the sealing strength resulting from heat sealing after placing a cryopreservation container in the packages is very good. Therefore, liquid nitrogen can be inhibited from entering the inside and thus contamination with bacteria, viruses or the like contained in liquid nitrogen can be avoided and the package can be prevented from being broken by expansion of intruder liquid nitrogen on the occasion of thawing. Also disclosed is a method for packaging a cryopreservation container and a method of producing a package for a cryopreservation container.
摘要翻译： 一种用于至少包含粘合性氟聚合物膜的冷冻保存容器的包装。 用于冷冻保存容器的包装使得可以在非常低的温度环境中储存血液，稀有细胞和重要组织，而不会对容器造成任何损害。 此外，将冷冻保存容器放置在包装中之后的热封所产生的密封强度非常好。 因此，可以抑制液氮进入内部，因此可以避免液氮中含有的细菌，病毒等的污染，并且可以防止在解冻时通过入侵者液氮的膨胀破坏包装。 还公开了一种用于包装冷冻保存容器的方法和一种生产用于冷冻保存容器的包装的方法。
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公开(公告)号：US20110223243A1
公开(公告)日：2011-09-15
申请号：US13003400
申请日：2009-07-08
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , A61K9/1647 , A61K9/5031 , A61K9/5153 , A61K31/755
摘要： The invention relates to dispersions of artificial oxygen carriers, wherein the dispersions contain capsules with reversible oxygen storage capacity, the capsules comprising an oxygen-permeable capsule material, that contains and/or encloses fluorinated, particularly perfluorinated hydrocarbons, preferably perfluorocarbons. The dispersions are particularly suitable as a blood substitute, preferably for the purpose of transfusion, e.g. in states of blood loss of the human or animal body, in particular following surgical interventions, accidents, injuries etc, or for the prophylactic treatment and/or treatment by therapy of ischaemic states or states following a reperfusion.
摘要翻译： 本发明涉及人造氧载体的分散体，其中分散体含有具有可逆储氧能力的胶囊，所述胶囊包含透氧胶囊材料，其含有和/或包围氟化的，特别是全氟化烃，优选全氟化碳。 分散体特别适合作为血液替代物，优选用于输血的目的，例如， 在人或动物身体的失血状态下，特别是在手术干预，事故，损伤等之后，或通过再灌注后缺血状态或状态的治疗进行预防性治疗和/或治疗。
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86.发明授权公开(公告)号：US08017311B2
公开(公告)日：2011-09-13
申请号：US11856650
申请日：2007-09-17
IPC分类号： A01N1/00
CPC分类号： A01N1/0221 , A01N1/02
摘要： Living cellular material may be preserved by incubating the cellular material in a culture medium containing at least one sugar, particularly for at least three hours, and then subjecting the cellular material to a preservation protocol, such as freezing, vitrification, freeze-drying and desiccation.
摘要翻译： 活细胞材料可以通过将细胞材料在含有至少一种糖的培养基中培养来保存，特别是至少3小时，然后使细胞材料进行保存方案，如冷冻，玻璃化，冷冻干燥和干燥 。
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公开(公告)号：US08015841B2
公开(公告)日：2011-09-13
申请号：US11897448
申请日：2007-08-30
申请人： Alan Cheng
发明人： Alan Cheng
IPC分类号： F25J1/00
CPC分类号： A01N1/02 , A01N1/0252 , F25D3/10 , F25D17/02 , F25D2400/02 , F26B5/06
摘要： A cryogenic refrigeration system includes a cryogenic heat exchanger system adapted for vaporizing a liquid cryogen and using the gaseous cryogen to cool heat transfer fluid and a heat transfer cooling circuit that cools the lyophilization chamber as well as the condenser. The disclosed heat transfer cooling circuit includes a primary recirculation loop adapted for cooling the lyophilization chamber with the heat transfer fluid, a secondary recirculation loop adapted for cooling a condenser with the heat transfer fluid, and one or more valves operatively coupling the cryogenic heat exchanger system, the primary recirculation loop, and the secondary recirculation loop.
摘要翻译： 低温制冷系统包括适于蒸发液体冷冻剂并使用气态冷冻剂冷却传热流体的冷冻热交换器系统和冷冻冻干室以及冷凝器的传热冷却回路。 所公开的传热冷却回路包括适于用热传导流体冷冻冻干室的第一再循环回路，适于用传热流体冷却冷凝器的第二再循环回路，以及将低温热交换器系统 ，初级再循环回路和次级再循环回路。
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88.发明申请公开(公告)号：US20110171625A1
公开(公告)日：2011-07-14
申请号：US12930776
申请日：2011-02-07
申请人： Michael D. Cecchi
发明人： Michael D. Cecchi
IPC分类号： A01N1/00
CPC分类号： A01N1/0221 , A01N1/02
摘要： A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, antioxidants, fatty acids to supply the specimens with the chemical ingredients and uptake requirements required to recover and prosper during and after the cryopreservation process. The solution supplies nutrients to the specimens that will replenish depletion and damage to the specimens and their mitochondria, spindles and structural features, such as cell walls. One formulation addresses the additional requirements of frozen specimens as opposed to the current media solutions and methods which treat the un-frozen specimens the same as the frozen specimens when recovering them from cryopreservation.
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公开(公告)号：US07977115B2
公开(公告)日：2011-07-12
申请号：US11095700
申请日：2005-03-31
IPC分类号： G01N21/00
CPC分类号： A01N1/02 , A01N1/00 , A01N1/0221 , A23B4/064 , A23B4/068 , A23B7/0416 , A23B7/0433 , A23L3/36 , A23L3/362 , A23L3/364 , A23L3/37
摘要： A method of determining whether a brine composition for freezing an item is in a desired balance. The method includes: adding an effective amount of dye into the brine composition, cooling the dye composition to a pre-determined temperature, and comparing the color of the brine composition to a pre-established correlation of color and brine composition at the pre-determined temperature, thereby determining whether the brine composition is in the desired balance.
摘要翻译： 确定用于冷冻物品的盐水组合物是否处于期望的平衡的方法。 该方法包括：将有效量的染料加入到盐水组合物中，将染料组合物冷却至预定温度，并将盐水组合物的颜色与预先确定的颜色和盐水组成的预先确定的相关性进行比较 温度，从而确定盐水组合物是否处于期望的平衡。
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90.发明授权Composition and method for the restoration and preservation of transplant organs procured from DCD donors 有权从DCD供体采购的移植器官的恢复和保存的组成和方法公开(公告)号：US07977042B2
公开(公告)日：2011-07-12
申请号：US11460261
申请日：2006-07-27
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
摘要翻译： 本发明提供了包含特异性代谢剂，抗氧化剂和膜稳定剂的灌注溶液，所述代谢剂，抗氧化剂和膜稳定剂可以帮助改善保存，器官活力，并且在某些情况下可以回收否则不能用于移植的器官。 在另一个实施方案中，灌注溶液可以与低温机器灌注组合使用。 已经发现灌注溶液和低温机器灌注的组合可以有助于预防或减少对器官的进一步损伤并恢复器官的抗氧化系统，稳定细胞细胞骨架和细胞膜，抑制花生四烯酸途径，提供花药支持， 减少间质性水肿形成，并帮助恢复器官内的能量储存。 因此，该方法可用于改善否则边缘供体器官的生存力。
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