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    PACING SYSTEM FOR USE DURING CARDIAC CATHETERIZATION OR SURGERY
    82.
    发明申请
    PACING SYSTEM FOR USE DURING CARDIAC CATHETERIZATION OR SURGERY 审中-公开
    在心脏导管或手术期间使用的PACING系统

    公开(公告)号：US20100056858A1

    公开(公告)日：2010-03-04

    申请号：US12547316

    申请日：2009-08-25

    申请人： Eric A. Mokelke ,  Allan C. Shuros

    发明人： Eric A. Mokelke ,  Allan C. Shuros

    IPC分类号： A61N1/36 ,  A61B17/00

    CPC分类号： A61B17/0218 ,  A61B17/3207 ,  A61B2017/0243 ,  A61B2017/22001 ,  A61B2017/308 ,  A61B2090/3784 ,  A61N1/056 ,  A61N1/08 ,  A61N1/3625 ,  G16H40/63

    摘要： Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with cardiac catheterization or surgery. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more devices used in the cardiac catheterization or surgery. The pacemaker controls the delivery of the pacing pulses by executing a cardioprotective pacing protocol. In one embodiment, the one or more pacing electrodes are incorporated onto an intravascular ultrasound (IVUS) catheter. In another embodiment, the one or more pacing electrodes are incorporated onto one or more cardiac surgical instruments such as a heart stabilizer and a sternal retractor.

    摘要翻译： 应用心脏保护起搏来预防和/或减少与心脏导管插入术或手术相关的心脏损伤。 起搏脉冲从起搏器产生并通过一个或多个起搏电极输送，该起搏电极并入到用于心脏导管插入术或手术中的一个或多个装置上。 起搏器通过执行心脏保护起搏协议来控制起搏脉冲的输送。 在一个实施例中，将一个或多个起搏电极并入到血管内超声（IVUS）导管中。 在另一个实施例中，将一个或多个起搏电极并入一个或多个心脏外科器械，例如心脏稳定器和胸骨牵开器。

    SENSING VECTOR CONFIGURATION IN ICD TO ASSIST ARRHYTHMIA DETECTION AND ANNOTATION
    83.
    发明申请
    SENSING VECTOR CONFIGURATION IN ICD TO ASSIST ARRHYTHMIA DETECTION AND ANNOTATION 有权
    ICD中的感应矢量配置，以帮助ARRHYTHMIA检测和报告

    公开(公告)号：US20090306486A1

    公开(公告)日：2009-12-10

    申请号：US12478476

    申请日：2009-06-04

    申请人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

    发明人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

    IPC分类号： A61B5/046 ,  A61B5/02 ,  A61B5/0464

    CPC分类号： A61B5/0464 ,  A61B5/0215 ,  A61B5/0422 ,  A61B5/046 ,  A61N1/3622 ,  A61N1/3702

    摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.

    摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路， 到心脏信号感测电路。 所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定是否 快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

    SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING NERVE ROOTS
    85.
    发明申请
    SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING NERVE ROOTS 有权
    用于选择性刺激神经病变的系统和方法

    公开(公告)号：US20090270935A1

    公开(公告)日：2009-10-29

    申请号：US12431621

    申请日：2009-04-28

    申请人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    发明人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36117 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/37241

    摘要： Various system embodiments comprise an implantable lead, an implantable housing, a neural stimulation circuit in the housing, and a controller in the housing and connected to the neural stimulation circuit. The lead has a proximal end and a distal end. The distal end is adapted to deliver neural stimulation pulses to the ventral nerve root and the dorsal nerve root. The proximal end of the lead is adapted to connect to the housing. The neural stimulation circuit is adapted to generate neural stimulation pulses to stimulate the ventral nerve root or the dorsal nerve root using the implantable lead. The controller is adapted to control the neural stimulation circuit to deliver a neural stimulation treatment.

    摘要翻译： 各种系统实施例包括可植入引线，可植入壳体，壳体中的神经刺激电路以及壳体中的控制器并连接到神经刺激电路。 引线具有近端和远端。 远端适于将神经刺激脉冲输送到腹侧神经根和背神经根。 引线的近端适于连接到外壳。 神经刺激电路适于产生神经刺激脉冲，以使用可植入引线刺激腹侧神经根或背神经根。 控制器适于控制神经刺激电路以递送神经刺激治疗。

    Cardiac Lead Placement Using Multiple Spatially Distributed Sensors
    86.
    发明申请
    Cardiac Lead Placement Using Multiple Spatially Distributed Sensors 有权
    使用多个空间分布式传感器的心脏导联放置

    公开(公告)号：US20090157090A1

    公开(公告)日：2009-06-18

    申请号：US12236838

    申请日：2008-09-24

    申请人： Shantha Arcot-Krishnamurthy ,  Quan Ni ,  Michael Stucky ,  Allan C. Shuros

    发明人： Shantha Arcot-Krishnamurthy ,  Quan Ni ,  Michael Stucky ,  Allan C. Shuros

    IPC分类号： A61N1/05 ,  A61B17/00

    CPC分类号： A61N1/056 ,  A61N1/36514

    摘要： Systems and methods facilitate placement of a lead in or on a patient's heart. At least one reference sensor is positioned at a right heart location of a patient's heart and a cardiac lead apparatus comprising at least one lead apparatus sensor is advanced to a plurality of left heart locations. Using the reference sensor and the lead apparatus sensor, a distance parameter indicative of a distance between the reference and lead apparatus sensors is measured for each of the plurality of left heart locations. Strain or stress estimates are determined for the plurality of left heart locations derived from the distance parameter measurements. Using the strain or stress estimates, a physician perceivable output is produced indicating suitability of the left heart locations as pacing sites.

    摘要翻译： 系统和方法有利于将铅放置在患者心脏中或患者的心脏上。 至少一个参考传感器位于患者心脏的右心脏位置，并且将包括至少一个引导装置传感器的心脏引导装置提前到多个左心脏位置。 使用参考传感器和引导装置传感器，针对多个左心脏位置中的每一个测量指示参考和引导装置传感器之间的距离的距离参数。 对于从距离参数测量导出的多个左心脏位置确定应变或应力估计。 使用应变或压力估计，产生医生可感知的输出，指示左心脏位置作为起搏部位的适合性。

    CLOSED-LOOP CONTROL OF INTERMITTENT EXCITATORY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT
    87.
    发明申请
    CLOSED-LOOP CONTROL OF INTERMITTENT EXCITATORY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT 有权
    间歇性激素治疗效果的闭环控制

    公开(公告)号：US20090082825A1

    公开(公告)日：2009-03-26

    申请号：US11860957

    申请日：2007-09-25

    申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Christopher Hartemink

    发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Christopher Hartemink

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627

    摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. In order to provide a consistent hemodynamic response, the high-output pacing is optimized by delivering it using different parameter sets, evaluating the hemodynamic response thereto as reflected by one or more measured physiological variables, and selecting the parameter set with the best hemodynamic response.

    摘要翻译： 用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。 刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。 为了提供一致的血流动力学响应，通过使用不同的参数组递送高输出起搏，通过一个或多个测量的生理变量反映的血液动力学响应进行评估，并且选择具有最佳血液动力学响应的参数集来优化高输出起搏。

    METHOD AND DEVICE FOR MYOCARDIAL STRESS REDISTRIBUTION
    88.
    发明申请
    METHOD AND DEVICE FOR MYOCARDIAL STRESS REDISTRIBUTION 有权
    用于心肌应激再分配的方法和装置

    公开(公告)号：US20080234772A1

    公开(公告)日：2008-09-25

    申请号：US11689032

    申请日：2007-03-21

    申请人： Allan C. Shuros ,  Rodney W. Salo ,  Shantha Arcot-Krishnamurthy

    发明人： Allan C. Shuros ,  Rodney W. Salo ,  Shantha Arcot-Krishnamurthy

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627

    摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such an the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.

    摘要翻译： 描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。 预激发起搏可用于故意减压可能预期会发生有害重塑的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或故意压迫远离预激励起搏的区域 为了发挥心脏保护性调理作用，类似于运动的有益效果。 预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

    METHOD AND DEVICE FOR CARDIAC VASOACTIVE THERAPY
    89.
    发明申请
    METHOD AND DEVICE FOR CARDIAC VASOACTIVE THERAPY 失效
    CARDIAC VASOACTIVE治疗的方法和装置

    公开(公告)号：US20080132972A1

    公开(公告)日：2008-06-05

    申请号：US11566896

    申请日：2006-12-05

    申请人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Joseph Walker

    发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Joseph Walker

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3627 ,  A61F2/82 ,  A61N1/3688

    摘要： A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.

    摘要翻译： 一种用于治疗心肌缺血的方法和装置，其中植入式脉冲发生器将电刺激递送到设置在冠状动脉附近的电极。 可以调节刺激参数以产生动脉的血管舒张和/或血管收缩。 该装置可以被配置为根据指定的入口和出口条件在血管舒张和/或血管收缩模式中操作。