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公开(公告)号:US10100203B2
公开(公告)日:2018-10-16
申请号:US15324276
申请日:2015-07-07
摘要: A curable coating composition comprising: (a) a silicate, such as sodium silicate, potassium silicate or lithium silicate; (b) a phosphate, such calcium phosphate, magnesium phosphate or sodium phosphate; and (c) a metal oxide, such as magnesium oxide, aluminum (III) oxide, scandium (III) oxide, yttrium (III) oxide, or zirconium oxide. Such curable coating compositions may be used as non-thermochromic (tailored based on expected operating environment) thermal control coating compositions for application to spacecraft and components thereof. As an alternative metal oxide component, for use in lower temperature applications, or in applications for which thermochromism at elevated temperatures is not a concern, the metal oxide may comprise zinc oxide. Also provided is a curable coating composition comprising: (a) a silicate (e.g. as above); (b) a phosphate (e.g. as above); and (c) a metal sulphate, such as a barium sulphate. Cured coatings are also provided, as are thermal control coatings, thermal control paints, and processes for making coated substrates.
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公开(公告)号:US10022417B2
公开(公告)日:2018-07-17
申请号:US15310444
申请日:2015-05-12
发明人: Lorraine Brennan , Aisling Robinson , Nessa Noronha , Dick Fitzgerald , Alice Nongonierma , Therese Holton , Helen Roche , J C Jacquier , Denis Shields , Eileen Gibney
摘要: A peptide having 12 to 60 amino acids and including (a) a sequence of SEQUENCE ID NO: 11, or (b) a fragment of SEQUENCE ID NO: 11 that includes the sequence of SEQUENCE ID NO: 1 or 5, is described for use in improving glycemic management in a mammal. A composition, for example a food product, that includes substantially all of the peptides of SEQUENCE ID NO:'s 1 to 11, that is capable of reducing post-prandial blood glucose levels, and increasing insulin secretion in humans, is also described.
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83.
公开(公告)号:US20170355969A1
公开(公告)日:2017-12-14
申请号:US15536534
申请日:2015-12-09
发明人: Kevin O'Connor , Susan Molloy , Reeta Davis , Wesley Shaw
摘要: A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.
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公开(公告)号:US20170349849A1
公开(公告)日:2017-12-07
申请号:US15545520
申请日:2016-01-22
摘要: This invention relates to a method and apparatus for thermochemically processing material, and in particular relates to the torrefaction of organic material such as biomass, in particular to improve the energy content of the material, the method involving enclosing the material in a reactor which is then evacuated by means of a fluid driven vacuum pump to establish an oxygen free environment within the reactor, heating the material to above 200° C. to liberate process by-products such as volatile gases and/or oils, extracting the liberated volatile gases and/or oils from the enclosure and entraining same within the fluid driving the vacuum pump.
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公开(公告)号:US20170298020A1
公开(公告)日:2017-10-19
申请号:US15631796
申请日:2017-06-23
发明人: B. Therese Kinsella , Helen Reid
IPC分类号: C07D213/71 , C07D305/08 , C07D295/192 , C07D277/34 , C07D261/08 , A61K31/18 , C07D231/12 , C07D213/85 , C07D213/34 , C07D205/04 , C07D307/42 , C07D263/48
摘要: The invention generally relates to methods and compounds for treating proliferative disorders, viral infections, or both. In some embodiments, the invention provides an anticancer or antiviral compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating a proliferative disorder or a viral infection including administering an anticancer or antiviral compound that binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (TPβ) receptor subtype.
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公开(公告)号:US20170050930A1
公开(公告)日:2017-02-23
申请号:US15194745
申请日:2016-06-28
申请人: University College Dublin National University of Ireland, Dublin , The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Hol
发明人: Breandan Noel KENNEDY , Alison REYNOLDS , Claire KILTY , Jacintha O'SULLIVAN , Andrew Douglas BAXTER
IPC分类号: C07D215/14 , A61K31/47 , A61K9/00
CPC分类号: C07D215/14 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K31/47 , A61K31/4725
摘要: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.
摘要翻译: (E)-2-(2-喹啉-2-基 - 丙烯基) - 苯酚,2-喹啉-2-基 - 乙炔基 - 苯酚及其盐可用作药物,特别是用于治疗血管发生相关疾病或病症 。
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公开(公告)号:US20170015572A1
公开(公告)日:2017-01-19
申请号:US15124927
申请日:2015-03-11
发明人: Eoin CASEY , Eoin SYRON
摘要: The present invention is concerned with a hollow fibre membrane for use in a Membrane Supported Biofilm Reactor (MSBR) or the like, the hollow fibre membrane comprising a substantially cylindrical sidewall defining an internal lumen from which gas can permeate through the sidewall, and characterised in that at least a part of an outer surface of the fibre membrane is engineered to define at least one biofilm retaining region which acts to retain a quantity of biofilm therein, in particular when the fibre membrane is subjected to a high sheer biofilm control event, such as experienced during a reactor cleaning cycle, for removing excess biofilm in order to prevent clogging of the reactor.
摘要翻译: 本发明涉及用于膜支持生物膜反应器(MSBR)等的中空纤维膜,中空纤维膜包括限定内腔的基本上圆柱形的侧壁,气体可以从该内腔渗透通过侧壁,并且其特征在于 纤维膜的外表面的至少一部分被工程化以限定至少一个生物膜保持区域,其用于在其中保留一定量的生物膜,特别是当纤维膜经受高纯度的生物膜控制事件时,例如 如在反应器清洁循环期间经历的,用于除去过量的生物膜以防止反应器堵塞。
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公开(公告)号:US09388138B2
公开(公告)日:2016-07-12
申请号:US14415078
申请日:2013-07-15
申请人: University College Dublin National University of Ireland, Dublin , The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Holy
发明人: Breandan Douglas Kennedy , Alison Reynolds , Claire Kilty , Jacintha O'Sullivan , Andrew Douglas Baxter
IPC分类号: C07D215/38 , A61K31/47 , C07D215/14 , A61K31/4725
CPC分类号: C07D215/14 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K31/47 , A61K31/4725
摘要: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.
摘要翻译: (E)-2-(2-喹啉-2-基 - 丙烯基) - 苯酚,2-喹啉-2-基 - 乙炔基 - 苯酚及其盐可用作药物,特别是用于治疗血管发生相关疾病或病症 。
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89.
公开(公告)号:US09328004B2
公开(公告)日:2016-05-03
申请号:US14188631
申请日:2014-02-24
发明人: Eoin Casey , Eoin Syron , Barry Heffernan
IPC分类号: B01D61/12 , B01D65/10 , B01D65/02 , B01D63/02 , G01B13/06 , C02F3/00 , C02F3/10 , B01D61/10 , B01D69/08
CPC分类号: C02F3/006 , B01D61/10 , B01D61/12 , B01D63/02 , B01D65/02 , B01D65/10 , B01D69/08 , B01D2311/14 , B01D2311/16 , B01D2311/26 , B01D2321/18 , B01D2321/40 , C02F3/102 , G01B13/06 , Y02W10/15
摘要: A method of assessing biofilm thickness in a membrane supported biofilm reactor (MSBR) of the type comprising a lumen containing a gas phase, a liquid phase, and a gas permeable membrane providing an interface between the gas and liquid phases, the method comprising the steps of charging the lumen with an inert gas, closing the lumen to establish an initial elevated pressure in the lumen, measuring the rate of change of pressure within the lumen, and correlating the rate of change of pressure (dP/dt) with biofilm thickness. The step of correlating dP/dt with biofilm thickness involves correlating dP/dt with the rate of diffusion of the inert gas (dn/dt), correlating dn/dt with an overall mass transfer coefficient (K), correlating K with the mass transfer coefficient of the biofilm (kB), and correlating kB with the biofilm thickness. Also described is a membrane supported biofilm reactor (MSBR) of the type comprising a gas permeable membrane providing an interface between a lumen containing a gas phase, and a liquid phase, characterized in that the MSBR comprises means for flushing the lumen with an inert gas, means for closing and re-opening the lumen, and means for detecting intra-membrane pressure within the lumen. The means for detecting intra-membrane pressure is provided by a pressure transducer.
摘要翻译: 一种评估膜支撑生物膜反应器(MSBR)中的生物膜厚度的方法,该生物膜反应器(MSBR)包括含有气相,液相和气体可渗透膜的腔,其提供气相和液相之间的界面,所述方法包括步骤 用惰性气体填充内腔,关闭内腔以在内腔中建立初始升高的压力,测量内腔内的压力变化率,并将压力变化率(dP / dt)与生物膜厚度相关联。 将dP / dt与生物膜厚度相关的步骤涉及将dP / dt与惰性气体扩散速率(dn / dt)相关联,将dn / dt与总传质系数(K)相关联,将K与质量传递相关联 生物膜的系数(kB),并将kB与生物膜厚度相关联。 还描述了一种膜支持的生物膜反应器(MSBR),其包括提供在含有气相的内腔和液相之间的界面的气体可渗透膜,其特征在于,MSBR包括用惰性气体冲洗内腔的装置 用于关闭和重新打开内腔的装置,以及用于检测内腔内的膜内压力的装置。 用于检测膜内压力的装置由压力传感器提供。
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公开(公告)号:US09291818B2
公开(公告)日:2016-03-22
申请号:US14400354
申请日:2013-05-16
发明人: Fergal O'Reilly , Kenneth Fahy , Paul Sheridan
CPC分类号: G02B27/0006 , G01N21/15 , G02B1/11
摘要: A self-cleaning optical system for the transmission or reflection of light to and/or from a process region comprises a liquid bath and a transparent or reflective optical component continuously rotatable about a non-vertical axis so that a lower part of the component continuously rotates through the bath. When the component emerges from the bath, a coating of the liquid remains thereon which forms a substantially uniform film on at least a part of the component through which the light is transmitted or from which the light is reflected.
摘要翻译: 用于将光传输或反射到处理区域和/或来自处理区域的自清洁光学系统包括液槽和可绕非垂直轴线连续旋转的透明或反射光学部件,使得部件的下部部分连续旋转 通过洗澡 当组分从浴中出来时,液体的涂层保留在其上,在透射光的部件的至少一部分上或者光被反射的部分上形成基本均匀的膜。
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