公开(公告)号：US20240091308A1

公开(公告)日：2024-03-21

申请号：US18317277

申请日：2023-05-15

申请人： DEVINTEC SAGL

发明人： Miguel Angel Alonso Cohen ,  Rossana Sidoti ,  Bhavna Karnani

IPC分类号： A61K38/16 ,  A61K31/573 ,  A61K47/36 ,  A61P19/02

CPC分类号： A61K38/168 ,  A61K31/573 ,  A61K47/36 ,  A61P19/02

摘要： The present invention provides pea protein and compositions comprising pea protein for use in the prevention and/or treatment of autoimmune arthritis. The invention also provides said compositions for use in combination therapy with an antirheumatic drug. The invention also provides compositions comprising pea protein, alpha-glucooligosaccharide, acacia gum, and an antirheumatic drug, and their use as a medicament. The compositions of the invention are particularly useful for treating rheumatoid arthritis.

公开(公告)号：US20240091266A1

公开(公告)日：2024-03-21

申请号：US18262505

申请日：2022-01-21

申请人： Silviu ITESCU ,  Roger BROWN

发明人： Silviu ITESCU ,  Roger BROWN

IPC分类号： A61K35/28 ,  A61K47/36 ,  A61P25/04

CPC分类号： A61K35/28 ,  A61K47/36 ,  A61P25/04

摘要： The present disclosure relates to opioid sparing compositions and use of the same for reducing opioid use. Such compositions and methods method may be used for reducing pain or reducing opioid use or increasing mobility in subjects using an opioid.

公开(公告)号：US11925668B2

公开(公告)日：2024-03-12

申请号：US18051983

申请日：2022-11-02

申请人： CHAMBIO CO., LTD.

发明人： Meei-Yn Lin ,  Hung-Pin Chiu ,  Yi-Heng Chiu

IPC分类号： A61K35/747 ,  A01N63/20 ,  A23L33/135 ,  A61K35/00 ,  A61K35/741 ,  A61K35/745 ,  A61K39/085 ,  A61K47/36 ,  A61K47/42 ,  A61K35/744

CPC分类号： A61K35/747 ,  A01N63/20 ,  A23L33/135 ,  A61K35/741 ,  A61K35/745 ,  A61K39/085 ,  A61K47/36 ,  A61K47/42 ,  A23V2002/00 ,  A23V2400/113 ,  A23V2400/127 ,  A23V2400/517 ,  A23V2400/531 ,  A23V2400/533 ,  A61K2035/115 ,  A61K35/744

摘要： Disclosed herein is a process for producing a postbiotic extract, which includes providing a first material having a first isoelectric point ranging from pH 1 to pH 6 and a second material having a second isoelectric point ranging from pH 4 to pH 8, admixing the first material and a probiotic microorganism with water having a pH greater than the second isoelectric point, so as to form a mixture, adding the second material into the mixture and then adjusting a pH of the second material-added mixture to between the first and second isoelectric points so that a precipitate is formed, and subjecting the precipitate to a cell wall isolation treatment to obtain the postbiotic extract. Use of the postbiotic extract is also disclosed.

公开(公告)号：US20240066094A1

公开(公告)日：2024-02-29

申请号：US18474456

申请日：2023-09-26

申请人： University of Florida Research Foundation, Inc.

发明人： Daiqing Liao ,  Iqbal Mahmud ,  Guimei Tian

IPC分类号： A61K38/04 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00

CPC分类号： A61K38/04 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00 ,  A61K45/06

摘要： Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.

公开(公告)号：US20240065985A1

公开(公告)日：2024-02-29

申请号：US18456758

申请日：2023-08-28

申请人： Curio IP, LLC

发明人： Amanda Karwic ,  Donald J. Treacy, JR. ,  Bruce Artman ,  Edward M. Rudnic

IPC分类号： A61K31/01 ,  A61K9/00 ,  A61K31/015 ,  A61K31/045 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61K47/46

CPC分类号： A61K31/01 ,  A61K9/0056 ,  A61K31/015 ,  A61K31/045 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61K47/46

摘要： Compositions and dosage forms that contain volatile lipophilic compounds, and methods of manufacturing such compositions and dosage forms, are described.

公开(公告)号：US11911477B2

公开(公告)日：2024-02-27

申请号：US17646935

申请日：2022-01-04

申请人： Beihang University

发明人： Bing Zhou ,  Xunming Ji ,  Jing Liang ,  Panpan Yu ,  Rongrong Han

IPC分类号： A61K47/36 ,  A61P25/00 ,  A61K45/06

CPC分类号： A61K47/36 ,  A61K45/06 ,  A61P25/00

摘要： The present disclosure provides use of fructose in preparing a drug for treating a cerebral ischemic stroke, and relates to the technical field of biomedicine. In the present disclosure, an ischemic injury cell model and an ischemic injury animal model are established, and fructose treatment is conducted on the injury models; and it is found that the fructose can regulate energy metabolism and redox metabolism of neurons, and reduce an ischemic injury of model cells and model animals. Specifically, the present disclosure includes: reducing a neuronal mortality after the ischemic injury, reducing an area of cerebral infarction in animals with the ischemic injury, and improving neurobehavioral characteristics of the animals.

公开(公告)号：US11911379B2

公开(公告)日：2024-02-27

申请号：US17570928

申请日：2022-01-07

申请人： ADS Therapeutics LLC

发明人： Jinsong Ni ,  Rong Yang

IPC分类号： A61K31/496 ,  A61K9/00 ,  A61K9/08 ,  A61K9/107 ,  A61K31/365 ,  A61K31/404 ,  A61K31/407 ,  A61K31/416 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/675 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  A61P27/02 ,  A61P27/06

CPC分类号： A61K31/496 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/08 ,  A61K9/107 ,  A61K31/365 ,  A61K31/404 ,  A61K31/407 ,  A61K31/416 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/675 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/186 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  A61P27/02 ,  A61P27/06

摘要： Compositions and methods of using nintedanib for treating indications with abnormal neovascularization in the front part of the eye are disclosed.

公开(公告)号：US11896628B2

公开(公告)日：2024-02-13

申请号：US17856013

申请日：2022-07-01

申请人： Artugen Therapeutics Ltd.

发明人： Ronald Farquhar ,  Christopher K. Murphy ,  Colin Hill ,  Paul Ross ,  Mary Rea ,  Michelle O'Donnell ,  Brian Healy ,  Laurent Chesnel

IPC分类号： A61K35/74 ,  A61P1/12 ,  A61K9/19 ,  A61K45/06 ,  A61K47/36

CPC分类号： A61K35/74 ,  A61K9/19 ,  A61K45/06 ,  A61K47/36 ,  A61P1/12

摘要： Disclosed herein are compositions and methods for preventing, ameliorating, or treating Clostridium difficile infections and/or reducing the severity of one or more risk factors, signs, or symptoms associated with C. difficile infections. In particular, the technology of the present disclosure relates to methods for administering an effective amount of a composition comprising strains of Bacillus amyloliquefaciens bacteria identified as ART24, ART4, and ART 12, to a subject suffering from or at risk for C. difficile infections.

公开(公告)号：US11896575B2

公开(公告)日：2024-02-13

申请号：US16756689

申请日：2018-10-16

申请人： Delivra Inc.

发明人： Joseph Gabriele ,  Mikaela Teris

IPC分类号： A61K31/352 ,  A61K9/00 ,  A61K9/107 ,  A61K31/05 ,  A61K31/137 ,  A61K31/167 ,  A61K31/445 ,  A61K31/485 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/36 ,  A61K47/38

CPC分类号： A61K31/352 ,  A61K9/006 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/107 ,  A61K31/05 ,  A61K31/137 ,  A61K31/167 ,  A61K31/445 ,  A61K31/485 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/36 ,  A61K47/38

摘要： The present application includes a transdermal base formulation useful for example, for the transdermal delivery of active pharmaceutical ingredients along with a process for preparation thereof. In particular, the transdermal base formulation comprises: (a) an aqueous phase comprising water and at least one emulsion stabilizer; (b) an oil phase comprising at least one emulsifier, at least one emulsion stabilizer, at least one emollient comprising at least one flavonoid, at least one other emollient, and a terpene-rich natural butter; (c) an external phase comprising at least one terpene-rich extract or oil, at least one penetration enhancer and a phospholipid-complexed flavonoid; and optionally (d) at least one preservative phase.

公开(公告)号：US20240041852A1

公开(公告)日：2024-02-08

申请号：US18487241

申请日：2023-10-16

申请人： ARMS Pharmaceutical LLC

发明人： Afif Ghannoum ,  Brian Vincent Sokol

IPC分类号： A61K31/4425 ,  A61K45/06 ,  A61K9/00 ,  A61K31/155 ,  A61K47/10 ,  A61K47/36

CPC分类号： A61K31/4425 ,  A61K45/06 ,  A61K9/006 ,  A61K31/155 ,  A61K47/10 ,  A61K47/36 ,  Y02A50/30

摘要： A method for treating a disease or for treating a symptom of a disease, or a combination of both, the disease being caused or aggravated by microorganisms includes: treating the disease, treating the symptom of the disease, or reducing the duration of the disease, or a combination of both by administering a barrier-forming composition in a therapeutically effective amount to a surface, the surface comprising a mammal mucosa, the mammal being infected with the disease or experiencing symptoms of the disease caused or aggravated by the microorganisms. The barrier-forming composition includes an antimicrobial. Upon administering the composition, the method includes forming a barrier coating on the surface that is active to kill or neutralize microorganisms encountered by the barrier coating. A composition with an agent active for relieving symptoms of a disease is also included.