公开(公告)号：US09972482B2

公开(公告)日：2018-05-15

申请号：US15634151

申请日：2017-06-27

Applicant: Smiths Detection Montreal Inc.

Inventor： Jan Hendrikse ,  Vladimir Romanov

IPC: H01J49/16 ,  H01J49/14 ,  H01J49/00 ,  H01J49/24 ,  H01J49/04

CPC classification number: H01J49/168 ,  G01N33/0057 ,  H01J49/0004 ,  H01J49/0022 ,  H01J49/0036 ,  H01J49/0404 ,  H01J49/145 ,  H01J49/24

Abstract: A concentric APCI surface ionization probe, supersonic sampling tube, and method for use of the concentric APCI surface ionization probe and supersonic sampling tube are described. In an embodiment, the concentric APCI surface ionization probe includes an outer tube, an inner capillary, and a voltage source coupled to the outer tube and the inner capillary. The inner capillary is housed within and concentric with the outer tube such that ionized gas (e.g., air) travels out of the outer tube, reacts with a sample, and the resulting analyte ions are sucked into the inner capillary. A supersonic sampling tube can include a tube coupled to a mass spectrometer and/or concentric APCI surface ionization probe, where the tube includes at least one de Laval nozzle.

公开(公告)号：US09934953B1

公开(公告)日：2018-04-03

申请号：US15194917

申请日：2016-06-28

Applicant: Elemental Scientific, Inc.

Inventor： Nathan Saetveit ,  Daniel R. Wiederin

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/14

CPC classification number: H01J49/105 ,  B05B14/45 ,  H01J49/0031 ,  H01J49/0077 ,  H01J49/045 ,  H01J49/145

Abstract: A system for determining an analyte by inductively coupled plasma mass spectrometry (ICPMS) includes a sample introduction device having a heated cyclonic spray chamber. The system is configured to introduce sample that includes a metal and/or a metalloid having an organic interferent. The system also includes an inductively coupled plasma mass spectrometry device with a collision/reaction cell configured to receive a mixture of gases including both ammonia and hydrogen. A method includes introducing a sample to plasma to produce a characteristic spectrum associated with an elemental composition of the sample. The method also includes introducing both ammonia and hydrogen to a collision/reaction cell to remove carbon-based interferences to detection of the sample prior to determining the elemental composition of the sample.

公开(公告)号：US09916972B2

公开(公告)日：2018-03-13

申请号：US14897690

申请日：2014-06-11

Applicant: University of Helsinki

Inventor： Mikko Sipilä ,  Heikki Junninen ,  Douglas Worsnop

IPC: H01J49/10 ,  H01J49/14 ,  H01J49/12 ,  H01J49/26 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/145 ,  G01N27/622 ,  H01J49/0077 ,  H01J49/12 ,  H01J49/26

Abstract: A device for ionizing sample particles of a sample gas flow comprises a first flow tube for providing the sample gas flow, and an introducing means for providing H2SO4 molecules to an interaction region. In addition the device comprises a generator for producing reagent primary ions from particles of candidate reagent gas flow essentially in a primary ion production region. The device is configured to introduce said reagent primary ions with H2SO4 molecules in said interaction region in order to arrange interaction between the reagent primary ions and the H2SO4 molecules, thereby producing HSO4− ions and again to produce HSO4− ion clusters comprising HSO4− ions and at least two H2SO4 molecules via interactions of HSO4− with other H2SO4 molecules in said interaction region. Furthermore the device is configured to introduce said HSO4− ion clusters with the sample particles of the sample gas flow in order to provide reactions between said HSO4− ion clusters and the sample particles, and thereby provide a sample cluster comprising the HSO4− ion clusters and said base sample to be determined.

公开(公告)号：US20180068840A1

公开(公告)日：2018-03-08

申请号：US15256626

申请日：2016-09-05

Applicant: Agilent Technologies, Inc.

Inventor： Kenneth R. Newton

IPC: H01J49/04 ,  H01J49/24 ,  H01J49/14

CPC classification number: H01J49/0404 ,  H01J49/145 ,  H01J49/24

Abstract: An ion transfer device for transferring ions from one chamber to another, reduced-pressure chamber includes an inlet section and a main capillary section. The inlet section has a lumen and the main capillary section has a bore communicating with the lumen. The inside diameter of the lumen is less than that of the bore. The inlet section may be removable from an installation site separately from the main capillary section. The ion transfer device may be utilized, for example, in an atmospheric-pressure interface of a mass spectrometer.

公开(公告)号：US20180061622A1

公开(公告)日：2018-03-01

申请号：US15558389

申请日：2016-08-24

Applicant: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY ,  AMR INCORPORATED

Inventor： Kanako SEKIMOTO ,  Mitsuo TAKAYAMA ,  Hiroshi HIKE ,  Motoshi SAKAKURA

IPC: H01J49/14

CPC classification number: H01J49/145 ,  H01J49/168

Abstract: An atmospheric pressure ionization method uses: a gas flow passage control unit (26) and a gas outlet nozzle (24) configured to jet argon gas to an atmospheric atmosphere; a needle electrode (19) arranged between an outlet port of the gas outlet nozzle (24) and an introduction port of an ion introduction pipe (6) that includes a tip end portion formed into a curved surface; a needle electrode support mechanism (20); and an electric power generation unit (22) configured to apply extremely low electric power to the needle electrode (19). The atmospheric pressure ionization method includes: applying the extremely low electric power to the needle electrode (19) from the electric power generation unit (22) to generate a dark discharge; exciting the argon gas with the dark current; and causing the excited argon gas and the sample to react with each other, to thereby ionize the sample.

公开(公告)号：US20180024099A1

公开(公告)日：2018-01-25

申请号：US15548864

申请日：2016-09-06

Applicant: Huajun Zhang

Inventor： Huajun Zhang ,  Ning Ying

IPC: G01N30/72

CPC classification number: G01N30/72 ,  G01N30/7206 ,  G01N2560/00 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/145 ,  H01J49/165

Abstract: The present invention provides a mass spectrometric detection and analysis method, comprising the steps of: selecting, as a perturbation condition, one or more parameters of a mass spectrometer during detection, setting a set of different numeric values for the perturbation condition, detecting by the mass spectrometer a substance to be detected under the different numeric values of the perturbation condition to obtain a set of mass spectrometric data; calculating the set of obtained mass spectrometric data by an entropy minimization algorithm to obtain independent ions in the mass spectrometric data and kinetic processes thereof; and performing mass spectrometric analysis on the basis of the obtained independent ions and kinetic processes thereof. The method of the present invention can quickly and accurately perform qualitative analysis on the substances to be detected, especially on substances that are difficult to distinguish with existing mass spectrometric techniques such as isomers and homologues. The method of the present invention can also perform analysis by the difference between the kinetic processes and thereby determine the nature of such substances. The method of the present invention has a very broad application prospect due to its simple operation and accurate results of analysis.

公开(公告)号：US09759685B2

公开(公告)日：2017-09-12

申请号：US14800410

申请日：2015-07-15

Applicant: Brechtel Manufacturing, Inc.

Inventor： Fredrick J Brechtel ,  Xerxes Lopez-Yglesias

IPC: H01J49/26 ,  G01N30/32 ,  G01N27/66 ,  G01R29/24 ,  H01J27/02 ,  G01N27/62 ,  H01J49/14 ,  H01J49/16

CPC classification number: G01N27/66 ,  G01N27/624 ,  G01R29/24 ,  H01J27/02 ,  H01J49/145 ,  H01J49/161

Abstract: A system and method comprising an ion production chamber having a ultra-violet light source disposed towards said chamber, a harvest gas disposed to flow through the chamber from an inlet to an outlet, and a jet, said jet operable to introduce a sample into the harvest gas flow. In some embodiments the system includes using helium as the harvest gas. Certain embodiments include introducing a sample perpendicular to the harvest gas flow and using multiple sample introduction jets to increase mixing efficiency. The charge sample may be coupled to a MEMS-based electrometer.

公开(公告)号：US09696325B2

公开(公告)日：2017-07-04

申请号：US14816586

申请日：2015-08-03

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Scott M. Goldman ,  Julie A. Neidich

IPC: G01N33/92 ,  G01N33/26 ,  G01N30/72 ,  G01N24/00 ,  H01J49/00 ,  H01J49/16 ,  H01J49/26 ,  H01J49/14

CPC classification number: G01N33/92 ,  G01N30/7266 ,  G01N33/26 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/145 ,  H01J49/165 ,  H01J49/168 ,  Y10T436/104165 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.

公开(公告)号：US09691598B2

公开(公告)日：2017-06-27

申请号：US14909256

申请日：2013-08-02

Applicant: SHIMADZU CORPORATION ,  Public University Corporation Yokohama City University

Inventor： Kanako Sekimoto ,  Mitsuo Takayama ,  Daisuke Okumura

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/14 ,  H01J49/26

CPC classification number: H01J49/167 ,  H01J49/142 ,  H01J49/145 ,  H01J49/168 ,  H01J49/26

Abstract: In the ionizer of the present invention, a stream of gas spouted from a nozzle (18) of a DART ionization unit (10) vaporizes and ionizes the components in a sample (25). Gaseous sample-component molecules which have not been ionized by that process are subsequently ionized by a reaction with a reactant ion produced by a corona discharge generated from a needle electrode (20). Such a two-stage ionization of the sample-component molecules improves the ionization efficiency. A needle-electrode support mechanism (21) adjusts the position and/or angle of the needle electrode (20) and thereby controls a potential gradient. Therefore, a specific sample-derived ion species can be efficiently introduced into an ion introduction tube (31) and be detected with a high level of sensitivity.

公开(公告)号：US20170169999A1

公开(公告)日：2017-06-15

申请号：US15388368

申请日：2016-12-22

Applicant: Micromass UK Limited

Inventor： David GORDON ,  Daniel James KENNY

IPC: H01J49/00 ,  H01J49/24 ,  H01J49/14

CPC classification number: H01J49/0013 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/145 ,  H01J49/24 ,  H01J49/40

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.