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公开(公告)号:US09453079B2
公开(公告)日:2016-09-27
申请号:US14292461
申请日:2014-05-30
Applicant: Genentech, Inc.
Inventor: Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07K16/18 , A61K39/395 , C07K16/40 , A61K47/48 , G01N33/573 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号:US09360484B2
公开(公告)日:2016-06-07
申请号:US14078241
申请日:2013-11-12
Applicant: Genentech, Inc.
Inventor: Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
IPC: C07K16/00 , G01N33/68 , A61K47/48 , C07K16/28 , G01N33/574 , A61K31/138 , A61K31/4196 , A61K31/454 , A61K31/4745 , A61K31/517 , A61K31/56 , A61K31/568 , A61K31/5685 , A61K31/69 , A61K33/24 , A61K38/19 , A61K39/395 , A61K39/00
CPC classification number: G01N33/6854 , A61K31/138 , A61K31/4196 , A61K31/454 , A61K31/4745 , A61K31/517 , A61K31/56 , A61K31/568 , A61K31/5685 , A61K31/69 , A61K33/24 , A61K38/19 , A61K39/0011 , A61K39/39533 , A61K39/39558 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/283 , C07K2317/24 , C07K2317/522 , C07K2317/73 , G01N33/574 , G01N33/6857 , Y02A50/473
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20150232568A1
公开(公告)日:2015-08-20
申请号:US14421103
申请日:2013-08-13
Applicant: Genentech, Inc.
Inventor: Christian W. Siebel , Yan Wu
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The disclosure provides anti-Jagged antibodies and methods of using the same.
Abstract translation: 本公开提供抗锯齿抗体及其使用方法。
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公开(公告)号:US20150218276A1
公开(公告)日:2015-08-06
申请号:US14582100
申请日:2014-12-23
Applicant: GENENTECH, INC.
Inventor: Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
IPC: C07K16/28
CPC classification number: C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
Abstract translation: 目前公开的主题提供了结合KLB和FGFR1的抗体及其使用方法。 在某些实施方案中,本公开的抗体包括结合存在于FGFR1上并与KLB上存在的表位结合的双特异性抗体。
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公开(公告)号:US20150104461A1
公开(公告)日:2015-04-16
申请号:US14298488
申请日:2014-06-06
Applicant: Genentech, Inc.
Inventor: Siebel W. Christian , Yan Wu
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The invention provides anti-Notch antibodies, and in particular, antibodies that bind Notch2 NRR, and methods of using the same.
Abstract translation: 本发明提供抗Notch抗体,特别是结合Notch2 NRR的抗体及其使用方法。
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公开(公告)号:US20140234312A1
公开(公告)日:2014-08-21
申请号:US13915363
申请日:2013-06-11
Applicant: Genentech, Inc.
Inventor: Yan Wu , Wei-Ching Liang , Ryan Jefferson Watts , Anil Durgadas
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/31 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: The invention provides Nrp2 antagonists, such as anti-Nrp2 antibodies, and their use in the prevention and treatment of tumor metastasis.
Abstract translation: 本发明提供Nrp2拮抗剂,例如抗Nrp2抗体,以及它们在预防和治疗肿瘤转移中的用途。
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公开(公告)号:US20130046078A1
公开(公告)日:2013-02-21
申请号:US13653293
申请日:2012-10-16
Applicant: Genentech, Inc.
Inventor: Avi Ashkenazi , Jing Qing , Christian Wiesmann , Yan Wu
IPC: C07K16/28
CPC classification number: C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
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公开(公告)号:US12281165B2
公开(公告)日:2025-04-22
申请号:US17677283
申请日:2022-02-22
Applicant: Genentech, Inc.
Inventor: Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K31/404 , A61K31/5517 , A61K31/706 , A61K38/05 , A61K47/68 , C07K16/30 , G01N33/574 , A61K39/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号:US12134649B2
公开(公告)日:2024-11-05
申请号:US17547528
申请日:2021-12-10
Applicant: Genentech, Inc.
Inventor: Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K38/08 , A61K39/395 , A61K47/65 , A61K47/68 , A61K51/10 , A61P35/00 , C07K16/30 , G01N33/569 , A61K39/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号:US11845799B2
公开(公告)日:2023-12-19
申请号:US17119753
申请日:2020-12-11
Applicant: Genentech, Inc.
Inventor: WeiYu Lin , Christoph Spiess , Liping Sun , Yan Wu , Cecilia P. C. Chiu , Walter Christian Darbonne , Michael Andrew Dillon
CPC classification number: C07K16/2824 , C07K16/2809 , A61K2039/507 , C07K2317/565 , C07K2317/567 , C07K2317/92
Abstract: Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.
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