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公开(公告)号：US20200308304A1
公开(公告)日：2020-10-01
申请号：US16852136
申请日：2020-04-17
Applicant: GENENTECH, INC.
Inventor： Yu-Ju G. Meng , Hok Seon Kim , Ingrid Kim , Christoph Spiess
IPC: C07K16/42
Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.
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公开(公告)号：US10246518B2
公开(公告)日：2019-04-02
申请号：US15837801
申请日：2017-12-11
Applicant: Genentech, Inc.
Inventor： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US09884919B2
公开(公告)日：2018-02-06
申请号：US15214160
申请日：2016-07-19
Applicant: GENENTECH, INC.
Inventor： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
IPC: A61K39/395 , C07K16/40 , C07K14/71 , C07K16/28 , A61K39/00
CPC classification number: C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US09873748B2
公开(公告)日：2018-01-23
申请号：US14582100
申请日：2014-12-23
Applicant: GENENTECH, INC.
Inventor： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC classification number: C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US20160319038A1
公开(公告)日：2016-11-03
申请号：US15214160
申请日：2016-07-19
Applicant: GENENTECH, INC.
Inventor： YONGMEI CHEN , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC classification number: C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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Patent Agency Ranking
公开(公告)号：US20240026033A1
公开(公告)日：2024-01-25
申请号：US18194276
申请日：2023-03-31
Applicant: Genentech, Inc.
Inventor： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC classification number: C07K16/40 , C07K14/71 , C07K16/2863 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/75 , C07K2317/92 , C07K2317/40 , C07K2317/41 , C07K2317/524 , C07K2317/567 , C07K2317/71 , A61K2039/505
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US20220064331A1
公开(公告)日：2022-03-03
申请号：US17341990
申请日：2021-06-08
Applicant: GENENTECH, INC.
Inventor： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US20190177432A1
公开(公告)日：2019-06-13
申请号：US16284774
申请日：2019-02-25
Applicant: GENENTECH, INC.
Inventor： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US20190040142A1
公开(公告)日：2019-02-07
申请号：US15974369
申请日：2018-05-08
Applicant: GENENTECH, INC.
Inventor： Diana Ronai Dunshee , Joanne Hongo , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Angie Grace Yee
IPC: C07K16/28
Abstract: The presently disclosed subject matter relates to multispecific antibodies, e.g., bispecific antibodies and biepitopic antibodies, and methods for screening for such antibodies, and a novel antibody structure that can be used to screen for such bispecific antibodies and biepitopic antibodies. The present disclosure further provides bispecific anti-KLB antibodies and methods
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公开(公告)号：US20180305462A1
公开(公告)日：2018-10-25
申请号：US15967154
申请日：2018-04-30
Applicant: GENENTECH, INC.
Inventor： Yu-Ju G. Meng , Hok Seon Kim , Ingrid Kim , Christoph Spiess
IPC: C07K16/42
CPC classification number: C07K16/4283 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/71 , C07K2317/75 , C07K2317/76 , C07K2317/94
Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.
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