公开(公告)号：US20190040142A1

公开(公告)日：2019-02-07

申请号：US15974369

申请日：2018-05-08

Applicant: GENENTECH, INC.

Inventor： Diana Ronai Dunshee ,  Joanne Hongo ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Angie Grace Yee

IPC: C07K16/28

Abstract: The presently disclosed subject matter relates to multispecific antibodies, e.g., bispecific antibodies and biepitopic antibodies, and methods for screening for such antibodies, and a novel antibody structure that can be used to screen for such bispecific antibodies and biepitopic antibodies. The present disclosure further provides bispecific anti-KLB antibodies and methods