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    Personal care products which include dihydroxypropyltri(C1-C3 alkyl) ammonium salts
    74.
    发明申请
    Personal care products which include dihydroxypropyltri(C1-C3 alkyl) ammonium salts 有权
    包括二羟丙基（C 1 -C 3烷基）铵盐的个人护理产品

    公开(公告)号：US20060088495A1

    公开(公告)日：2006-04-27

    申请号：US10972483

    申请日：2004-10-25

    Applicant: Bijan Harichian ,  Richard Mc Manus ,  Jose Rosa

    Inventor： Bijan Harichian ,  Richard Mc Manus ,  Jose Rosa

    IPC: A61K8/41

    CPC classification number: A61Q19/08 ,  A61K8/416 ,  A61Q1/02 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/10

    Abstract: A personal care product is provided which includes a composition containing dihydroxypropyltri(C1-C3 alkyl) ammonium salt in a carrier. The composition is packaged for delivery to a consumer and includes instructions printed on or associated with the packaging indicating topical use of the composition on skin, hair or the oral mucosae. Particularly useful is dihydroxypropyltrimonium chloride which operates as a humectant to moisturize both at high and low relative humidity environments.

    Abstract translation: 提供了一种个人护理产品，其包括在载体中含有二羟丙基（C 1 -C 3 -C 3烷基）铵盐的组合物。 将组合物包装以递送至消费者，并包括印刷在包装上或与包装有关的说明，指示组合物在皮肤，毛发或口腔粘膜上的局部使用。 特别有用的是二羟丙基三甲基氯化铵，其作为湿润剂在高和低相对湿度环境下均湿润。

    Process for making carboxyalkylates of branched alcohols
    75.
    发明申请
    Process for making carboxyalkylates of branched alcohols 失效
    制备支链醇的羧烷基化物的方法

    公开(公告)号：US20060047168A1

    公开(公告)日：2006-03-02

    申请号：US10926222

    申请日：2004-08-25

    Applicant: Bijan Harichian ,  Jose Rosa ,  Victor De Florio

    Inventor： Bijan Harichian ,  Jose Rosa ,  Victor De Florio

    IPC: C07C62/08

    CPC classification number: C07C51/367 ,  C07C59/70

    Abstract: Process for carboxy-alkylation, particularly carboxymethylation, of branched alcohols includes the reaction of isoalcohols with potassium-t-butoxide or sodium-t-butoxide and with salt of halogenated alkanoic acid in the presence of the isoalcohol (starting alcohol) as the solvent. Produced are isoalcohol carboxy-alkylates (preferably, carboxymethylates) in excellent yields and purity.

    Abstract translation: 支链醇的羧基烷基化，特别是羧甲基化的方法包括在异构醇（起始醇）作为溶剂的存在下，异构醇与叔丁醇钾或叔丁醇钠和卤代链烷酸盐的反应。 产生的产物和纯度优异的是异烷基羧基烷基化物（优选羧甲基化物）。

    Skin lightening agents, compositions and methods
    76.
    发明申请
    Skin lightening agents, compositions and methods 有权
    护肤剂，组合物和方法

    公开(公告)号：US20050191250A1

    公开(公告)日：2005-09-01

    申请号：US10789293

    申请日：2004-02-27

    Applicant: Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

    Inventor： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

    IPC: A61K8/365 ,  A61K8/37 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732 ,  A61K7/42 ,  A61K7/135

    CPC classification number: A61K8/365 ,  A61K8/37 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732

    Abstract: Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

    Abstract translation: 披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或 杂烷基 和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或 杂芳基。 在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表 甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备 。 本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。 还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。

    Skin lightening agents, compositions and methods
    77.
    发明授权
    Skin lightening agents, compositions and methods 失效
    护肤剂，组合物和方法

    公开(公告)号：US06875425B2

    公开(公告)日：2005-04-05

    申请号：US10317484

    申请日：2002-12-12

    Applicant: Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Michael Tallman

    Inventor： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Michael Tallman

    IPC: A61K8/49 ,  A61Q19/02 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44

    CPC classification number: A61K8/4986 ,  A61K8/49 ,  A61Q19/02

    Abstract: Cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Wherein X represents Carbon, Nitrogen, Sulfur or Oxygen; each A1 and/or A2 independently is =H or COR, CO2R, CONHR having the following formula A: where R=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is C1-C18 saturated or unsaturated hydrocarbon or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon.

    Abstract translation: 使用式I化合物作为皮肤增亮剂的化妆品组合物和皮肤发白方法：其中X表示碳，氮，硫或氧;每个A1和/或A2独立地为= H或COR，CO 2 R，CONHR，具有下式A： 其中R = C1-C18饱和或不饱和的直链或支链烃; Y 1和/或Y 2独立地是C 1 -C 18饱和或不饱和烃或OZ，其中Z = H或COR 1，CO 2 R 1，CONHR 1，其中R 1 = C1- C18饱和或不饱和的直链或支链烃。

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