公开(公告)号：US20060047168A1

公开(公告)日：2006-03-02

申请号：US10926222

申请日：2004-08-25

Applicant: Bijan Harichian ,  Jose Rosa ,  Victor De Florio

Inventor： Bijan Harichian ,  Jose Rosa ,  Victor De Florio

IPC: C07C62/08

CPC classification number: C07C51/367 ,  C07C59/70

Abstract: Process for carboxy-alkylation, particularly carboxymethylation, of branched alcohols includes the reaction of isoalcohols with potassium-t-butoxide or sodium-t-butoxide and with salt of halogenated alkanoic acid in the presence of the isoalcohol (starting alcohol) as the solvent. Produced are isoalcohol carboxy-alkylates (preferably, carboxymethylates) in excellent yields and purity.

Abstract translation: 支链醇的羧基烷基化，特别是羧甲基化的方法包括在异构醇（起始醇）作为溶剂的存在下，异构醇与叔丁醇钾或叔丁醇钠和卤代链烷酸盐的反应。 产生的产物和纯度优异的是异烷基羧基烷基化物（优选羧甲基化物）。

公开(公告)号：US20090175812A1

公开(公告)日：2009-07-09

申请号：US12406643

申请日：2009-03-18

Applicant: Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Victor De Florio ,  Jose Guillermo Rosa ,  Michael Tallman

Inventor： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Victor De Florio ,  Jose Guillermo Rosa ,  Michael Tallman

IPC: A61K8/49 ,  C07D339/06 ,  C07D339/08 ,  C07D339/00 ,  A61Q19/02

CPC classification number: A61Q19/02 ,  A61K8/4986 ,  C07D339/00 ,  C07D339/06 ,  C07D339/08

Abstract: Compounds of formula I, process for making same, and cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Where each A1 and/or A2 independently is ═H or COR, CO2R, CONHR, the latter three having the following formula A: where R═C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is H; C1-C18 saturated or unsaturated hydrocarbon; or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1═C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; X is Carbon, Nitrogen, Sulfur, or Oxygen; and N is in integer between 0 and 2.

Abstract translation: 式I的化合物，其制备方法，以及使用式I化合物作为皮肤增亮剂的化妆品组合物和皮肤发白的方法：其中每个A1和/或A2独立地为-H或COR，CO 2 R，CONHR，后者三个具有 下式A：其中R-C1-C18饱和或不饱和的直链或支链烃; 并且每个Y1和/或Y2独立地为H; C1-C18饱和或不饱和烃; 或OZ，其中Z = H或COR1，式B的CO 2 R 1，CONHR：其中R 1 -C 1 -C 18饱和或不饱和的直链或支链烃; X是碳，氮，硫或氧; 并且N在0和2之间的整数。

公开(公告)号：US07211687B2

公开(公告)日：2007-05-01

申请号：US10926222

申请日：2004-08-25

Applicant: Bijan Harichian ,  Jose Guillermo Rosa ,  Victor De Florio

Inventor： Bijan Harichian ,  Jose Guillermo Rosa ,  Victor De Florio

IPC: C07C69/02 ,  C07C59/01

CPC classification number: C07C51/367 ,  C07C59/70

Abstract: Process for carboxy-alkylation, particularly carboxymethylation, of branched alcohols includes the reaction of isoalcohols with potassium-t-butoxide or sodium-t-butoxide and with salt of halogenated alkanoic acid in the presence of the isoalcohol (starting alcohol) as the solvent. Produced are isoalcohol carboxy-alkylates (preferably, carboxymethylates) in excellent yields and purity.

Abstract translation: 支链醇的羧基烷基化，特别是羧甲基化的方法包括在异构醇（起始醇）作为溶剂的存在下，异构醇与叔丁醇钾或叔丁醇钠和卤代链烷酸盐的反应。 产生的产物和纯度优异的是异烷基羧基烷基化物（优选羧甲基化物）。

公开(公告)号：US07524485B2

公开(公告)日：2009-04-28

申请号：US10718988

申请日：2003-11-21

Applicant: Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Victor De Florio ,  Jose Guillermo Rosa ,  Michael Tallman

Inventor： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Victor De Florio ,  Jose Guillermo Rosa ,  Michael Tallman

IPC: A61K8/18 ,  A61Q17/04 ,  A61K8/00 ,  A61Q5/00 ,  A61Q9/00 ,  A61K8/02

CPC classification number: A61Q19/02 ,  A61K8/4986 ,  C07D339/00 ,  C07D339/06 ,  C07D339/08

Abstract: Compounds of formula I, process for making same, and cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Where each A1 and/or A2 independently is =H or COR, CO2R, CONHR, the latter three having the following formula A: where R=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is H; C1-C18 saturated or unsaturated hydrocarbon; or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; X is Carbon, Nitrogen, Sulfur, or Oxygen; and N is in integer between 0 and 2.

Abstract translation: 式I的化合物，其制备方法，以及使用式I化合物作为皮肤增白剂的化妆品组合物和皮肤发白剂的方法：其中每个A1和/或A2独立地为= H或COR，CO 2 R，CONHR，后三者具有 下式A：其中R = C1-C18饱和或不饱和的直链或支链烃; 并且每个Y1和/或Y2独立地为H; C1-C18饱和或不饱和烃; 或OZ，其中Z = H或COR1，CO 2 R 1，式B的CONHR1：其中R 1 = C 1 -C 18饱和或不饱和的直链或支链烃; X是碳，氮，硫或氧; 并且N在0和2之间的整数。

公开(公告)号：US06379716B2

公开(公告)日：2002-04-30

申请号：US09798592

申请日：2001-03-02

Applicant: Uma Santhanam ,  Ronni Lynn Weinkauf ,  Laura Rose Palanker ,  Bijan Harichian ,  Victor De Florio

Inventor： Uma Santhanam ,  Ronni Lynn Weinkauf ,  Laura Rose Palanker ,  Bijan Harichian ,  Victor De Florio

IPC: A01N3700

CPC classification number: A61Q17/00 ,  A61K8/365 ,  A61K8/97 ,  A61K2800/75 ,  A61Q19/08

Abstract: Echinacea extract in cosmetic skin care compositions, as anti-irritant, to reduce skin irritation caused by hydroxy acids, and to boost the anti-aging efficacy of hydroxy acids.

Abstract translation: 紫锥菊提取物在化妆品护肤组合物中作为抗刺激剂，以减少由羟基酸引起的皮肤刺激，并提高羟基酸的抗衰老功效。