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公开(公告)号:US20250003987A1
公开(公告)日:2025-01-02
申请号:US18707545
申请日:2022-11-08
Applicant: Randox Laboratories Ltd.
Inventor: Paul Innocenzi , Stephen Peter Fitzgerald , Ivan McConnell
Abstract: A method is described for the identification of individuals with a BMI of less than 25 who have a biochemical profile that corresponds to an overweight or obese phenotype. The method of highlighting this hidden obesity makes use of various biomarker combinations that can incorporate various analytes including leptin and complement C3.
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公开(公告)号:US20240201178A1
公开(公告)日:2024-06-20
申请号:US18284783
申请日:2022-03-31
Applicant: RANDOX LABORATORIES LTD. , RANDOX TEORANTA
Inventor: Peter Fitzgerald , John Victor Lamont , Ivan McConnell , Ciaran Richardson , Philip Lowry , Jim Curry
IPC: G01N33/543 , G01N33/68
CPC classification number: G01N33/54353 , G01N33/54393 , G01N33/6857 , G01N2650/00
Abstract: The present invention relates to improved detection assays via the utilisation of a substrate with an analyte immobilised on its surface by means of a linking agent and a cross-linker. The present invention also relates to a method of producing a substrate for use in detection assays and a method of detecting an analyte using said substrate.
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公开(公告)号:US20240091783A1
公开(公告)日:2024-03-21
申请号:US18273737
申请日:2022-01-21
Applicant: RANDOX LABORATORIES LTD , Randox Teoranta
Inventor: Dale Love , Peter Fitzgerald , Ivan McConnell , Christina McFadden
IPC: B01L9/00
CPC classification number: B01L9/523 , B01L2200/025
Abstract: There is provided a bracket for a biological sample analyser. The bracket comprises abase and an arm extending from the base, the base being engageable with a platform of a biological sample analyser, wherein, when the base is engaged with the platform, the arm extends into a sample plate bay of the biological sample analyser prohibiting access to a portion of the bay. The arm thereby limits misalignment of a sample plate in the bay by blocking access to a portion of the bay only required when the sample plate is loaded into the bay in an incorrect orientation. A biological sample analyser comprising a bay in which a sample plate is loadable in use and the bracket is also provided.
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公开(公告)号:US20240003910A1
公开(公告)日:2024-01-04
申请号:US18037968
申请日:2021-11-15
Applicant: RANDOX LABORATORIES LTD
Inventor: Paul Innocenzi , Peter Fitzgerald , McMaster Steven
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N2800/7042
Abstract: Methods and products for adjusting the chronological age of a biological system or an individual to provide finer scale insight to health status are provided. The methods are underpinned by various serum and urinary biomarkers including antistreptolysin.
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公开(公告)号:US11602757B2
公开(公告)日:2023-03-14
申请号:US16341436
申请日:2017-10-13
Applicant: Randox Laboratories Ltd.
Inventor: Stuart Jackson , Stephen Peter Fitzgerald , Ivan McConnell , John Lamont
IPC: B01F33/452 , C12N15/10 , B03C1/01 , B03C1/28 , B01F101/23
Abstract: There is provided a method of extracting material from a fluid method of extracting material from a fluid, the fluid being held within a fluid chamber. The method comprises drawing, with a magnetic field generating system, at least one magnetically susceptible member through the fluid around a closed path between at least three points in the chamber, said at least one member being adapted to bind to material in fluid in the chamber. The at least three points are arranged relative to each other in a shape having at least two dimensions, the magnetic field generating system being configured to move the at least on magnetically susceptible member directly between the at least three points, material in the fluid binding to the at least one magnetically susceptible member when it comes into contact with the at least one member as it moves through the fluid.
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公开(公告)号:US20220349882A1
公开(公告)日:2022-11-03
申请号:US17630101
申请日:2020-07-26
Applicant: Randox Laboratories Ltd , Randox Teoranta
Inventor: Peter Fitzgerald , Ivan McConnell , Ciaran Richardson , John Lamont
IPC: G01N33/543 , G01N33/569
Abstract: The current invention provides a multiplex method for screening bovine samples for antibodies against several important pathogens. These pathogens include Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpesvirus-1 (BoHV-1), Mycobacterium paratuberculosis (MAP), Leptospira species, Neospora caninum and Fasciola hepatica. This multiplex screening is enabled by substrates with immobilized pathogen antigens and offer multiple advantages for the routine testing of farm animals.
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公开(公告)号:US20220011311A1
公开(公告)日:2022-01-13
申请号:US17294358
申请日:2019-11-15
Applicant: Randox Laboratories Ltd.
Inventor: Mark Ruddock , John Lamont , Stephen Fitzgerald , Kathleen Williamson
IPC: G01N33/574
Abstract: The present invention provides a method for detecting the presence or risk of bladder cancer in a female patient comprising the steps of detecting the presence of a panel of biomarkers in a sample isolated from a female patient, said panel of biomarkers comprising IL-13 and IL-12p70 and one or more biomarkers selected from BTA, Midkine, PAI-1/tPA, 8OHdG, CEA, CK18, Clusterin, Creatinine, CXCL16, Cystatin B, Cystatin C, d-Dimer, EGF, FAS, HAD, IL-1a, IL-1b, IL-4, IL-6, IL-7, IL-8, MCP-1, Microalbumin, MMP9NGAL, MMP9TIMP1, NGAL, NSE, Progranulin, TUP, TGFB1, Thrombomodulin, sTNFR1, TPA, VEGF and Triglycerides and/or the concentration of albumin/microalbumin/protein and creatinine expressed as an albumin:creatinine ratio in a sample isolated from a female patient; and assessing the results and comparing them to a normal control wherein an elevated presence of the biomarker compared to a normal control indicates the presence or risk of cancer in the patient from whom the sample is isolated.
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公开(公告)号:US20210316312A1
公开(公告)日:2021-10-14
申请号:US17265441
申请日:2019-08-02
Applicant: RANDOX LABORATORIES LTD
Inventor: Paul Courtney , Martin Reid , Stuart Jackson , John Lamont , Ivan McConnell , Peter Fitzgerald
Abstract: There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.
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公开(公告)号:US20210299655A1
公开(公告)日:2021-09-30
申请号:US17265434
申请日:2019-08-02
Applicant: RANDOX LABORATORIES LTD
Inventor: David Sloan , Stuart Jackson , John Lamont , Ivan McConnell , Peter Fitzgerald
IPC: B01L3/00
Abstract: A cartridge for polymerase chain reaction, PCR, comprises a vessel for PCR having an opening and a resealable membrane arranged, in use, to cover the opening of the vessel such that the opening of the vessel is vapour tight.
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公开(公告)号:US10914745B2
公开(公告)日:2021-02-09
申请号:US15457297
申请日:2017-03-13
Applicant: Randox Laboratories Ltd.
Inventor: John Lamont , Ivan McConnell , Peter Fitzgerald
IPC: G01N33/68 , C12Q1/6883
Abstract: The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.
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