公开(公告)号：US09970066B2

公开(公告)日：2018-05-15

申请号：US15224044

申请日：2016-07-29

Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE ,  ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY

Inventor： Bridget Barker ,  Elizabeth Driebe ,  David Engelthaler ,  Paul Keim ,  Jolene Bowers

IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC classification number: C12Q1/6895 ,  C12Q2600/112 ,  C12Q2600/16

Abstract: The present technology provides methods and kits that may be used to detect and quantify the presence of Coccidioides species. The methods include quantification real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.

公开(公告)号：US20180129802A1

公开(公告)日：2018-05-10

申请号：US15347727

申请日：2016-11-09

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Bertrand Francis Cambou

IPC: G06F21/46 ,  H04L9/06 ,  H04L9/08 ,  H04L9/32 ,  G06F21/44

CPC classification number: G06F21/46 ,  G06F21/44 ,  G06F2221/2103 ,  H04L9/0643 ,  H04L9/0866 ,  H04L9/0869 ,  H04L9/3226 ,  H04L9/3278

Abstract: The present invention provides a method for authenticating distributed peripherals on a computer network using an array of physically unclonable functions (PUF). As each PUF is unique, each PUF is able to generate a plurality of challenge response pairs that are unique to that PUF. The integrated circuits of the PUF comprise a plurality of cells, where a parameter (such as a voltage) of each cell may be measured (possibly averaged over many readings). The plurality of cells in the PUF may be arranged in a one, two or more dimensional matrix. A protocol based on an addressable PUF generator (APG) allows the protection of a network having distributed peripherals such as Internet of things (IoT), smart phones, lap top and desk top computers, or ID cards. This protection does not require the storage of a database of passwords, or secret keys, and thereby is immune to traditional database hacking attacks.

公开(公告)号：US20180093011A1

公开(公告)日：2018-04-05

申请号：US15725213

申请日：2017-10-04

Applicant: The Arizona Board of Regents on Behalf of Northern Arizona University ,  Dixie State University

Inventor： Robert Kellar ,  Nathan Christopher Nieto ,  Andrew Koppisch ,  Rico Del Sesto

IPC: A61L26/00 ,  A61K31/14 ,  A61K31/20 ,  A61K38/39 ,  A61K9/00

CPC classification number: A61L26/0038 ,  A61K9/0014 ,  A61K31/14 ,  A61K31/20 ,  A61K38/39 ,  A61L15/32 ,  A61L15/44 ,  A61L26/0033 ,  A61L26/0042 ,  A61L2300/404 ,  D01D5/0015 ,  D01D5/003 ,  D01F1/103

Abstract: Compositions for enhancing wound healing are disclosed herein. Also disclosed are methods of making the compositions and methods of using the compositions for the prevention of biofilm formation and for the inhibition of pathogen growth and proliferation.

公开(公告)号：US12208069B2

公开(公告)日：2025-01-28

申请号：US17457176

申请日：2021-12-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY ,  DIXIE STATE UNIVERSITY ,  TRIAD NATIONAL SECURITY, LLC ,  COLLEGE OF NEW JERSEY

Inventor： Andrew T. Koppisch ,  Gerrick E. Lindberg ,  David T. Fox ,  Joseph Baker ,  Alexanndra J. Heyert ,  Rico Del Sesto ,  Joshua R. Greene

IPC: A61K31/14 ,  A01N27/00 ,  A01N37/00 ,  A61K31/01 ,  A61K31/11 ,  A61K31/20

Abstract: Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.

公开(公告)号：US20250016010A1

公开(公告)日：2025-01-09

申请号：US18893566

申请日：2024-09-23

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University ,  Government of the United States of America, as represented by the Secretary of the Air Force

Inventor： Bertrand F. Cambou ,  Sareh Assiri ,  Christopher Robert Philabaum ,  H. Shelton Jacinto

IPC: H04L9/32 ,  H04L9/08 ,  H04L9/14

Abstract: Systems and methods for providing authentication and secure cryptographic communication between a client and server are described. The client includes an addressable array of PUF devices. The client receives or generates a set of instructions usable to determine a range of PUF addresses. The client measures the PUF addresses and generates a first set of responses. The responses are used to encrypt a session key, which is stored, along with the instructions and a hash of the responses, at the client. Later, the client may recover the session key by using the instructions to measure the PUF again, resulting in a second set of responses. Using a response-based cryptography search engine, the client may then iteratively modify and hash the second set of responses until a response set is uncovered that matches the first response set. This modified response set may then be used to uncover the session key.

公开(公告)号：US12133811B2

公开(公告)日：2024-11-05

申请号：US17515300

申请日：2021-10-29

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Zachary F Lerner ,  Grigoriy Orekhov ,  Leah Liebelt

IPC: A61F5/01

Abstract: An assistive ankle foot orthosis is described. The AFO has a tubular vertical member arranged laterally to a user's limb. The member carries a rotational bearing and a rotational element such as a pulley. The pulley is connected to a footplate. The footplate provides joint movement assistance or resistance to the user upon rotation of the pulley. The pulley is coupled to one or more springs that provide counter-rotational resistance to pulley movement, thereby storing, and then returning, rotational force during certain foot movements. The spring can include a leaf spring arranged inside the member, the stiffness of which can be manually, automatically or dynamically adjusted by movement of the device.

公开(公告)号：US12127963B2

公开(公告)日：2024-10-29

申请号：US18095940

申请日：2023-01-11

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Zachary F Lerner ,  Grigoriy Orekhov ,  Leah Liebelt

IPC: A61F5/01

CPC classification number: A61F5/0127 ,  A61F2005/0155 ,  A61F2005/0167 ,  A61F2005/0179

Abstract: An assistive ankle foot orthosis is described. The AFO has a tubular vertical member arranged laterally to a user's limb. The member carries a rotational bearing and a rotational element such as a pulley. The pulley is connected to a footplate. The footplate provides joint movement assistance or resistance to the user upon rotation of the pulley. The pulley is coupled to one or more springs that provide counter-rotational resistance to pulley movement, thereby storing, and then returning, rotational force during certain foot movements. The spring can include a leaf spring arranged inside the member, the stiffness of which can be manually, automatically or dynamically adjusted by movement of the device.

公开(公告)号：US20240348436A1

公开(公告)日：2024-10-17

申请号：US18638412

申请日：2024-04-17

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University ,  Brown University

Inventor： Bertrand F CAMBOU ,  Jeffrey HOFFSTEIN

IPC: H04L9/08 ,  H04L9/32

CPC classification number: H04L9/0869 ,  H04L9/3231 ,  H04L9/3271

Abstract: Methods for the encoding an encryption key for secure storage are disclosed. The methods rely on the use of unclonable, one-way functions, such as images of biological objects that may be measured according to challenges to result in responses. A biometric print of a biological object is measured with a set of n challenges resulting in n responses. The responses are an ordered sequence, with each response having a fixed position in the sequence. A key is generated of bit length n. A subset of m responses in the full set of n responses is selected, where the selected responses correspond to positions of is in the key. The response subset is stored. The key is then used, and deleted. A party wishing to re-generate the key generates the same set of challenges, measures the same biological object with the challenges a second time, and generates a second set of n responses. Responses in the stored subset of m responses will match responses in the second set of n responses at certain positions in second set of n responses. These matching positions correspond to is in the key. The non-matching positions correspond to Os. Thus, comparison between the response sets recovers the key.

公开(公告)号：US20240214224A1

公开(公告)日：2024-06-27

申请号：US18397975

申请日：2023-12-27

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Bertrand F. CAMBOU ,  Michael L. GARRETT

IPC: H04L9/32

CPC classification number: H04L9/3278 ,  H04L9/3231 ,  H04L9/3239

Abstract: Methods for the generation and use of session keys for authentication of a user of a server device are disclosed. The methods use a biological objects of the user to generate responses to challenges. During enrollment, the server device receives a password, hashes it a first number of times, and sends the hash to the user. The user interprets the hash as a set of challenges for the biological object, applies the challenges, and stores the responses. During authentication, the server hashes the password a second number of times, less than the first number, and sends the hash to the user. The user iteratively applies second hash to the biological object, compares the responses to the stored responses, and if there is not a match, hashes the challenges again until there is a match. The number of hashes needed for a match is a session key or subkey.

公开(公告)号：US11993812B2

公开(公告)日：2024-05-28

申请号：US17395432

申请日：2021-08-05

Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE ,  ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY

Inventor： Elizabeth Driebe ,  Jolene Bowers ,  David Engelthaler ,  Paul Keim

IPC: C12Q1/68 ,  C12Q1/686 ,  C12Q1/689

CPC classification number: C12Q1/686 ,  C12Q1/689 ,  C12Q2600/156 ,  C12Q2600/16

Abstract: Embodiments of the invention include methods of identifying microorganisms and/or diagnosing infections in subjects cause by microorganisms. Embodiments of the invention may also include further characterizing (e.g., determining the presence of one or more antibiotic resistance markers) the microorganisms and determining a strain identity of the microorganisms.