公开(公告)号：US09044162B2

公开(公告)日：2015-06-02

申请号：US13750341

申请日：2013-01-25

申请人： SenoRx, Inc.

发明人： Michael L. Jones ,  Paul Lubock ,  John Merritt

IPC分类号： A61B19/00 ,  A61B5/06 ,  A61B17/00 ,  A61M37/00 ,  A61B5/055 ,  A61B6/12 ,  A61B8/08 ,  A61B10/02 ,  A61M5/00

CPC分类号： A61B5/064 ,  A61B5/055 ,  A61B5/062 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B17/0057 ,  A61B90/39 ,  A61B2017/00637 ,  A61B2017/00898 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61K49/12 ,  A61K49/18 ,  A61K2123/00 ,  A61M5/007 ,  A61M37/0069

摘要： A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula.

摘要翻译： 标记输送装置包括细长的输送套管，其具有与内腔连通的远端部分中的远端部分，内腔和排出口。 至少一个细长的纤维标记物体可滑动地设置在细长的输送套管的内腔内。 所述至少一个细长的纤维标记物主体包括多个生物可吸收的聚合物链。 股线被压缩成压缩构型并且在插入细长的输送套管之前用压缩构型与聚合物粘合剂结合在一起。

公开(公告)号：US20150051477A1

公开(公告)日：2015-02-19

申请号：US14519531

申请日：2014-10-21

申请人： SenoRx, Inc.

发明人： Michael L. Jones ,  Paul Lubock ,  Lloyd H. Malchow

IPC分类号： A61B19/00

CPC分类号： A61B90/39 ,  A61B17/0057 ,  A61B2017/00637 ,  A61B2017/00898 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B2090/3987

摘要： An intracorporeal marker delivery system includes a delivery device including a delivery cannula and a plunger. The delivery cannula has an inner lumen, a distal tip, and a discharge opening in communication with the inner lumen. A radiographically detectable marker having a fibrous-body and a radiographically detectable marker element coupled to the fibrous body is disposed within and pushable by the plunger through the inner lumen of the delivery cannula. An MRI detectable distal tip plug is disposed at least in part within a distal portion of the inner lumen distal to the radiographically detectable marker, and configured to partially occlude the discharge opening in the delivery cannula. An ultrasound detectable short term marker is interposed between the radiographically detectable marker and the MRI detectable distal tip plug in the inner lumen of the delivery cannula.

摘要翻译： 体内标记递送系统包括包括递送套管和柱塞的递送装置。 输送套管具有内腔，远端头和与内腔连通的排出开口。 具有耦合到纤维体的纤维体和可放射线检测的标记元件的放射线检测标记设置在柱塞内并可通过输送套管的内腔推动。 MRI可检测的远侧末端插塞至少部分地设置在远离放射学检测标记的内腔的远端部分内，并且被构造成部分地封闭输送插管中的排出口。 超声可检测的短期标记置于放射线检测标记和输送插管的内腔中的MRI可检测的远侧末端塞之间。

公开(公告)号：US08915864B2

公开(公告)日：2014-12-23

申请号：US13683890

申请日：2012-11-21

申请人： SenoRx, Inc.

发明人： Richard L. Quick ,  Martin V. Shabaz ,  Frank R. Louw ,  Paul Lubock ,  Jason H. Safabash

IPC分类号： A61B10/00 ,  A61B10/02 ,  A61M1/00

CPC分类号： A61B10/0283 ,  A61B10/0266 ,  A61B10/0275 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2217/005 ,  A61M1/0056 ,  B01D29/0043 ,  B01D2221/10

摘要： The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid is applied to a fresh specimen. The tissue tray or basket within the tissue collector has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior.

摘要翻译： 本发明涉及一种用于从患者内的目标部位分离和收集一个或多个组织样本的系统和方法，并且在从活检装置移除样本之前冲洗样本以除去血液，碎屑等。 冲洗流体到组织收集器的流动优选地被控制以与一个或多个样品递送到装置的收集盘或篮子之间或者在组织收集器内接收到样本之后确保将流体施加到 新鲜标本。 组织收集器内的纸巾托盘或篮子具有开放或有孔的部分，以有助于从托盘上的组织标本中去除流体，例如所施加的流体和血液以及其它碎屑。 在组织收集器内提供真空，优选在托盘下面，以从收集器内部去除流体和碎屑。

公开(公告)号：US08882760B2

公开(公告)日：2014-11-11

申请号：US12229793

申请日：2008-08-27

申请人： Derek Daw ,  James Huntington Dabney

发明人： Derek Daw ,  James Huntington Dabney

IPC分类号： A61B18/10 ,  A61B18/14 ,  A61B18/12 ,  A61B18/18 ,  A61B18/00

CPC分类号： A61B18/1206 ,  A61B18/1402 ,  A61B18/18 ,  A61B2018/00601 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00755 ,  A61B2018/00875 ,  A61B2018/00946 ,  A61B2018/1286

摘要： A medical device system and method provide an RF electrosurgical generator coupled to an electrosurgical electrode via a patient box disposed in close proximity to the patient. An RF signal is delivered from the generator to the patient box where signal power is increased and the RF signal delivered to the electrosurgical electrode. The patient box is coupled to the electrosurgical electrode by a short cable capable of carrying an HV, high frequency 5 MHz signal without leakage. An electrical characteristic associated with the electrosurgical electrode is monitored and a desired RF power output and duty cycle maintained by adjusting DC input voltage applied to an RF amplifier, responsive to the monitoring. The system determines when the electrosurgical cutting electrode has started cutting and switches from a start mode to a run mode having a different RF duty cycle and a reduced RF power output controlled by a servo system.

摘要翻译： 一种医疗装置系统和方法，提供一种RF电外科发生器，其通过设置在患者附近的患者箱与电外科电极连接。 RF信号从发生器传送到患者箱，在信号功率增加并且RF信号传送到电外科电极。 患者盒通过能够承载HV，高频5MHz信号而不泄漏的短电缆耦合到电外科电极。 监测与电外科手术电极相关的电特性，并响应于监测，调整施加到RF放大器的DC输入电压来维持期望的RF功率输出和占空比。 该系统确定电外科切割电极何时开始切割并且从起动模式切换到具有不同RF占空比的运行模式以及由伺服系统控制的减少的RF功率输出。

公开(公告)号：US08795195B2

公开(公告)日：2014-08-05

申请号：US11284641

申请日：2005-11-22

申请人： Derek Daw ,  Frank R. Louw ,  Paul Lubock ,  Richard L. Quick ,  Martin V. Shabaz

发明人： Derek Daw ,  Frank R. Louw ,  Paul Lubock ,  Richard L. Quick ,  Martin V. Shabaz

IPC分类号： A61B10/02 ,  G06F3/16

CPC分类号： A61B5/061 ,  A61B5/742 ,  A61B10/0266 ,  A61B10/0275 ,  A61B90/10 ,  A61B90/37 ,  A61B2034/254

摘要： A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.

摘要翻译： 公开了一种用于组织活检系统的图形用户界面，该组织活检系统具有适于从患者内的目标部位的组织切割一个或多个组织标本的组织切割构件。 图形用户界面包括代表目标站点的第一区域的第一GUI区域，组织切割构件从该第一区域分离出一个或多个组织标本。 图形用户界面还包括第二GUI区域，其可视地与第一GUI区域区分开，代表第二区域，组织切割构件可从该第二区域将一个或多个附加的组织标本与目标部位的组织分开。

公开(公告)号：US08764741B2

公开(公告)日：2014-07-01

申请号：US11890945

申请日：2007-08-08

申请人： James Huntington Dabney ,  Richard L. Quick ,  Conrad Sawicz ,  Paul Lubock ,  Dan Kussman

发明人： James Huntington Dabney ,  Richard L. Quick ,  Conrad Sawicz ,  Paul Lubock ,  Dan Kussman

IPC分类号： A61B18/12 ,  A61B18/00

CPC分类号： G01R31/025 ,  A61B18/042 ,  A61B18/1206 ,  A61B18/16 ,  A61B18/18 ,  A61B34/35 ,  A61B2018/00601 ,  A61B2018/00607 ,  A61B2018/00666 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0094 ,  A61B2018/1213 ,  A61B2018/1266 ,  A61B2018/1286 ,  A61B2018/162

摘要： A high frequency electrosurgical power generator configured to produce electrical power at a frequency of about 1 to about 14 MHz and preferably having an essentially sinusoidal waveform with a voltage level up to 1,000 Vrms, and a current level up to 5 Amps. The output of the high frequency electrosurgical power generator is connected to an electrosurgical tool configured to receive the voltage and current produced by the electrosurgical power generator and deliver the voltage and current to an electrosurgical site. The output of the electrosurgical generator preferably is an essentially sinusoid waveform with a frequency between about 3 MHz and about 8 MHz, up to about 700 volts rms, up to about 2 amps, with a total power of up to 1,000 watts.

摘要翻译： 一种高频电外科发电机，其配置成以约1至约14MHz的频率产生电力，并且优选地具有基本上正弦波形，其电压电平高达1000Vrms，电流水平高达5安培。 高频电外科发电机的输出连接到电外科手术工具，其被配置为接收由电外科发电机产生的电压和电流，并将电压和电流传递到电外科手术部位。 电外科发生器的输出优选地是基本上是正弦波形，其频率在约3MHz至约8MHz之间，高达约700V rms，高达约2安培，总功率高达1,000瓦。

公开(公告)号：US20140121504A1

公开(公告)日：2014-05-01

申请号：US14148605

申请日：2014-01-06

申请人： SenoRx, Inc.

发明人： Lloyd H. Malchow ,  Paul Lubock ,  Derek Daw

IPC分类号： A61B10/02 ,  A61B8/08

CPC分类号： A61B10/0283 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/4405 ,  A61B8/4472 ,  A61B2017/00199 ,  A61B2090/378

摘要： A structurally integrated biopsy system includes a movable base having wheels to facilitate movement of the structurally integrated biopsy system. On the movable based there is mounted a tissue removal system, an ultrasound imaging system, and a controller. The tissue removal system includes a probe connector configured to connect to a tissue removal probe. The ultrasound imaging system is configured to generate an ultrasound image of a body region of a patient, and has an image display system having an image display screen to display ultrasound images taken by the ultrasound imaging system. The controller is configured to be in communication with each of the tissue removal system and the ultrasound imaging system to both provide control information for the ultrasound imaging system and provide control information for the tissue removal system in the structurally integrated biopsy system.

摘要翻译： 结构整合的活检系统包括具有轮子的可移动基座，以便于结构整合的活检系统的移动。 在可移动的基础上，安装有组织去除系统，超声成像系统和控制器。 组织去除系统包括配置成连接到组织去除探针的探针连接器。 超声波成像系统被配置为生成患者的身体区域的超声波图像，并且具有具有图像显示屏幕的图像显示系统，以显示由超声成像系统拍摄的超声波图像。 控制器被配置为与每个组织去除系统和超声成像系统连通，以提供用于超声成像系统的控制信息，并且提供在结构整合的活检系统中的组织去除系统的控制信息。

公开(公告)号：US20140039344A1

公开(公告)日：2014-02-06

申请号：US13749241

申请日：2013-01-24

申请人： SENORX, INC.

发明人： Richard L. Quick ,  Frank R. Louw ,  Paul Lubock ,  Martin V. Shabaz

IPC分类号： A61B10/02

CPC分类号： A61B10/0266 ,  A61B10/02 ,  A61B10/0233 ,  A61B10/0275 ,  A61B10/0283 ,  A61B17/32002 ,  A61B17/3417 ,  A61B90/30 ,  A61B90/39 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/0046 ,  A61B2017/00473 ,  A61B2017/3405 ,  A61B2017/3454 ,  A61B2090/0811 ,  A61B2090/309 ,  A61M1/0058 ,  B23Q17/2404 ,  F21V33/0068

摘要： The invention is directed to devices and methods for separating and collecting a tissue specimen from a patient's target site. The device includes a probe member with a penetrating distal tip and a tissue receiving aperture, and a tissue cutting member which is rotatable disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture. The longitudinal edges of the aperture are preferably sharpened to engage the cutting edges of the tissue cutting member. Vacuum may be provided in the inner lumen of the cutting member to transport tissue therethrough. Rotation, rotational oscillation and/or longitudinal reciprocation of the tissue cutting member is effective to separate a tissue specimen from surrounding tissue. An accessing cannula having an tissue receiving aperture may be concentrically disposed within the probe member and about the tissue cutting member. The tissue cutting edge of the tissue cutting member preferably is longitudinally oriented and may have a cutting angle less than 90° with respect to the longitudinal axis of the tissue cutting member.

摘要翻译： 本发明涉及用于从患者的目标部位分离和收集组织标本的装置和方法。 该装置包括具有穿透性远侧末端和组织接收孔的探针构件，以及组织切割构件，该组织切割构件可旋转地设置在探针构件内，以通过孔切割被拉入装置内部的组织样本。 孔的纵向边缘优选地被锐化以接合组织切割构件的切割边缘。 可以在切割构件的内腔中设置真空以将组织输送通过其中。 组织切割构件的旋转，旋转振动和/或纵向往复运动有效地将组织标本与周围组织分开。 具有组织接收孔的进入套管可以同心地设置在探针构件内并且围绕组织切割构件。 组织切割构件的组织切割边缘优选地纵向定向并且可以具有相对于组织切割构件的纵向轴线小于90°的切割角度。

公开(公告)号：US08639315B2

公开(公告)日：2014-01-28

申请号：US13895927

申请日：2013-05-16

申请人： SenoRx, Inc.

发明人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

IPC分类号： A61B6/00 ,  A61B10/00

CPC分类号： A61B90/39 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2090/3987 ,  A61K49/226

摘要： A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A marker is configured to be delivered to the cavity from the distal end of the delivery tube and is configured to remain with the porous bioabsorbable body within the cavity upon the formation thereof.

摘要翻译： 一种用于至少部分地填充和标记患者体内的部位的空腔的系统包括标记物输送装置，其具有被配置为容纳标记物质并具有被配置为排出标记物质的机构的室。 标记物质的量被容纳在标记物输送装置的室内。 标记物质构造成至少部分地填充空腔并在其中形成多孔生物可吸收体。 输送管与标记物递送装置的腔室流体连通地联接。 输送管具有远端，其具有排出口，排出标记物质。 标记被配置为从输送管的远端输送到空腔，并且构造成在其形成之后保留在空腔内的多孔生物可吸收体。

公开(公告)号：US08541764B2

公开(公告)日：2013-09-24

申请号：US13567303

申请日：2012-08-06

申请人： John Corbitt ,  Lori Anthony

发明人： John Corbitt ,  Lori Anthony

IPC分类号： A61N5/10

CPC分类号： A61F2/12 ,  A61B90/39 ,  A61B2090/3908 ,  A61B2090/3966 ,  A61F2250/0098 ,  A61N5/10 ,  A61N5/1049 ,  A61N2005/1061

摘要： A method of partial breast radiation therapy includes placing within a breast cavity a substantially radio-opaque implant constructed of biocompatible material, said substantially radio-opaque implant supporting the tissue surrounding the breast cavity; and directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast.

摘要翻译： 部分乳房放射治疗的方法包括在乳房腔内放置由生物相容性材料构成的基本不透射线的植入物，所述基本上不透射线的植入物支撑围绕乳房腔的组织; 以及将辐射束引导到所述基本上不透射线的植入物上，作为用于将辐射治疗递送到乳房腔周围的边缘的目标，使得辐射束不会实质地照射整个乳房。