公开(公告)号：US20170037073A1

公开(公告)日：2017-02-09

申请号：US15285057

申请日：2016-10-04

Applicant: ROQUETTE FRERESS

Inventor： Manuel BARATA ,  Pierrick DUFLOT ,  Abdelfattah BENSOUISSI ,  Mohamed MATHLOUTHI

IPC: C07H15/04 ,  A23L27/30

CPC classification number: C07H15/04 ,  A23L27/34 ,  A23V2002/00

Abstract: The invention concerns maltitol crystals, characterized in that they have a rectangular parallelepipedal shape and have a length to width dimensional ratio in the range 1.8 to 5.3, preferably 3±0.7, and a process for producing them.

Abstract translation: 本发明涉及麦芽糖醇晶体，其特征在于它们具有长方体形状并且具有1.8至5.3，优选3±0.7的长宽比尺寸比及其制备方法。

公开(公告)号：US09534008B2

公开(公告)日：2017-01-03

申请号：US14237786

申请日：2012-08-08

Applicant: Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder ,  Stephan H. Von Reuss ,  Fatma Kaplan ,  Peter A. Teal ,  Hans Alborn

Inventor： Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder ,  Stephan H. Von Reuss ,  Fatma Kaplan ,  Peter A. Teal ,  Hans Alborn

IPC: C07H15/04 ,  C07H15/10 ,  A01N63/02 ,  A01N43/16 ,  A01N37/36 ,  A61K31/7028 ,  A61K31/454 ,  C07H15/08 ,  C07H15/18 ,  C07H15/26 ,  A01N43/38 ,  C07D309/10

CPC classification number: C07H15/04 ,  A01N37/36 ,  A01N43/16 ,  A01N43/38 ,  A01N63/02 ,  A61K31/454 ,  A61K31/7028 ,  C07D309/10 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26

Abstract: The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a first location, and methods of treating or preventing parasite infection of a plant.

Abstract translation: 本发明涉及使用某些分离的调节剂化合物来修饰线虫行为的方法。 还公开了促进或抑制线虫群体繁殖的方法，在第一位置促进或抑制线虫聚集的方法，以及治疗或预防植物寄生虫感染的方法。

公开(公告)号：US09517243B2

公开(公告)日：2016-12-13

申请号：US14879476

申请日：2015-10-09

Applicant: The United States of America, as represented by the Secretary, Department of Health and Humam Services ,  The University of Birmingham, of Edgbaston

Inventor： Jay A. Berzofsky ,  Jessica J. O'Konek ,  Masaki Terabe ,  Petr A. Illarionov ,  Gurdyal S. Besra

IPC: A61K31/7032 ,  A61K45/06 ,  A61K38/20 ,  A61K39/00 ,  C07H15/06 ,  A61K31/7004 ,  C07H15/04

CPC classification number: A61K31/7032 ,  A61K31/7004 ,  A61K38/2013 ,  A61K39/00 ,  A61K39/0011 ,  A61K45/06 ,  A61K2039/585 ,  C07H15/04 ,  C07H15/06

Abstract: β-mannosylceramides or salts or solvates thereof in a pharmaceutically acceptable carrier, for use as a Type I NKT cell agonist in conjunction with a therapeutically effective amount of α-galactosylceramide or a salt or a solvate thereof, and/or at least one or more T-cell co-stimulatory molecules, disclosed. Compositions comprising β-mannosylceramide, as well as methods of treatment of tumors are also provided.

Abstract translation: β-甘露糖基神经酰胺或其盐或溶剂合物在药学上可接受的载体中，用作I型NKT细胞激动剂与治疗有效量的α-半乳糖神经酰胺或其盐或溶剂合物，和/或至少一种或多种 T细胞共刺激分子，公开。 还提供了包含β-甘露糖基神经酰胺的组合物以及治疗肿瘤的方法。

公开(公告)号：US20160355536A1

公开(公告)日：2016-12-08

申请号：US15238232

申请日：2016-08-16

Applicant: FUJIFILM Corporation

Inventor： Takayuki ITO ,  Toru WATANABE ,  Hideki OKADA ,  Hidenobu KUNIYOSHI

IPC: C07H13/08 ,  C07D333/32 ,  C07H15/04

CPC classification number: C07H13/08 ,  C07D333/32 ,  C07H15/04 ,  C07H15/18

Abstract: There is provided a production method of a compound represented by the following formula (II) through a step of reacting a compound represented by the following General Formula (I) with a sulfur compound. In General Formulas (I) and (II), R1 represents a hydrogen atom or an acyl group, R2 represents a hydrogen atom, a fluorine atom, an acyloxy group, an arylmethyloxy group, an allyloxy group, an arylmethyloxycarbonyloxy group, or an allyloxycarbonyloxy group, R3 represents a hydrogen atom or an acyloxy group, R5 represents an alkyl group or an aryl group, and X represents a leaving group. Here, in a case where R2 is a fluorine atom, an acyloxy group, an arylmethyloxy group, an allyloxy group, an arylmethyloxycarbonyloxy group, or an allyloxycarbonyloxy group, R3 is an acyloxy group.

Abstract translation: 在通式（I）和（II）中，R 1表示氢原子或酰基，R 2表示氢原子，氟原子，酰氧基，芳基甲氧基，烯丙氧基，芳基甲氧基羰基氧基或烯丙氧羰基氧基 基团，R 3表示氢原子或酰氧基，R 5表示烷基或芳基，X表示离去基团。 这里，在R 2为氟原子，酰氧基，芳基甲氧基，烯丙氧基，芳基甲氧基羰基氧基或烯丙氧基羰基氧基的情况下，R 3为酰氧基。

公开(公告)号：US09512158B2

公开(公告)日：2016-12-06

申请号：US13716570

申请日：2012-12-17

Applicant: NewLink Genetics Corp.

Inventor： Mario R. Mautino ,  Nicholas N. Vahanian ,  Won-Bin Young ,  Gabriela Rossi ,  Charles J. Link ,  Firoz Jaipuri

IPC: A61K39/00 ,  C07H5/04 ,  C07H15/04 ,  C07H15/00 ,  A61K39/39 ,  A61K31/70

CPC classification number: C07H5/04 ,  A61K31/70 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/55511 ,  C07H15/00 ,  C07H15/04

Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epitopes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

公开(公告)号：US09494515B2

公开(公告)日：2016-11-15

申请号：US13977202

申请日：2010-12-30

Applicant: Nikolay Vladimirovich Bovin ,  Nadezhda Vladimirovna Shilova

Inventor： Nikolay Vladimirovich Bovin ,  Nadezhda Vladimirovna Shilova

IPC: G01N21/64 ,  G01N33/533 ,  A61K49/00 ,  C07H15/04 ,  C07H15/12 ,  G01N33/543

CPC classification number: G01N21/6428 ,  A61K49/0043 ,  A61K49/0054 ,  C07H15/04 ,  C07H15/12 ,  G01N33/533 ,  G01N33/54393 ,  G01N2400/40

Abstract: The invention relates to glycan arrays with quantified levels of glycan expression and a method for fabricating thereof. The method comprises quantitatively reacting an ω-aminoalkylglycan with an activated polymer of an acrylic acid derivative to obtain glycoconjugated polymer or copolymer and covalently attaching the (co)polymer to a functionalized substrate. The glycan arrays according to the invention comprise an co-aminoalkylglycan covalently attached to a functionalized substrate via a fluorescently labeled (co)polymer of an acrylic acid derivative. The copolymer of the acrylic acid derivative may comprise fluorescein cadaverine as a fluorescent label or lysine or aminated PEG. The functionalized substrate is selected from an epoxylated and aminated glass or plastic. The invention also provides a fluorescently labeled co-aminoalkylglycan conjugated polymer of the acrylic acid derivative for use in the fabrication of glycan arrays.

Abstract translation: 本发明涉及具有定量水平的聚糖表达的聚糖阵列及其制备方法。 该方法包括将ω-氨基烷基糖胺与丙烯酸衍生物的活化聚合物定量反应以获得糖缀合的聚合物或共聚物，并将（共）聚合物共价连接到官能化底物上。 根据本发明的聚糖阵列包含通过丙烯酸衍生物的荧光标记（共）聚合物共价连接到官能化底物的共 - 氨基烷基糖基团。 丙烯酸衍生物的共聚物可以包含荧光素尸胺，作为荧光标记或赖氨酸或胺化PEG。 功能化底物选自环氧化和酰胺化玻璃或塑料。 本发明还提供用于制备聚糖阵列的丙烯酸衍生物的荧光标记的共 - 氨基烷基糖结合聚合物。

公开(公告)号：US09487596B2

公开(公告)日：2016-11-08

申请号：US14239136

申请日：2012-06-28

Applicant: Bong Hyun Chung ,  So Yeon Yi ,  Ui Jin Lee

Inventor： Bong Hyun Chung ,  So Yeon Yi ,  Ui Jin Lee

IPC: C07H15/04 ,  C08B37/00 ,  A61K36/39 ,  C07D407/12 ,  C07D407/14 ,  A23L1/29 ,  A61K31/715 ,  A61K45/06 ,  A61K31/351

CPC classification number: C08B37/006 ,  A23L33/40 ,  A61K31/351 ,  A61K31/715 ,  A61K36/39 ,  A61K45/06 ,  C07D407/12 ,  C07D407/14 ,  C07H15/04

Abstract: The present invention relates to a novel compound isolated from Quamoclit sp., and more particularly to a novel compound isolated from Quamoclit sp. and a composition for preventing or treating diabetes and its complications comprising the compound as an active ingredient. The novel compound isolated from Quamoclit sp. according to the present invention has excellent effects on lowering blood sugar, promoting insulin secretion, inhibiting VEGF expression, and so on. Thus, the present invention not only functions to prevent or treat diabetes and its complications, but also functions to promote treatment effects when treated together with conventional diabetes medicines.

Abstract translation: 本发明涉及从Quamoclit sp。分离的新化合物，更具体地说涉及从Quamoclit sp。分离的新型化合物。 以及用于预防或治疗糖尿病及其并发症的组合物，其包含该化合物作为活性成分。 从Quamoclit sp。 根据本发明对降低血糖，促进胰岛素分泌，抑制VEGF表达等具有优异的效果。 因此，本发明不仅起到预防或治疗糖尿病及其并发症的作用，而且还用于与常规糖尿病药物一起治疗时促进治疗效果的功能。

公开(公告)号：US09394328B2

公开(公告)日：2016-07-19

申请号：US14360583

申请日：2012-11-28

Applicant: SANDOZ AG

Inventor： Fritz Blatter ,  Katharina Reichenbaecher

IPC: C07H15/04 ,  A01N43/04 ,  A61K31/70 ,  C07H7/04 ,  C07D309/10

CPC classification number: C07H7/04 ,  C07D309/10

Abstract: A crystalline dapagliflozin hydrate and a process for obtaining the same is described.

Abstract translation: 描述了晶体达曲格式水合物及其获得方法。

公开(公告)号：US20160194349A1

公开(公告)日：2016-07-07

申请号：US14959714

申请日：2015-12-04

Applicant: Ionis Pharmaceuticals, Inc.

Inventor： Thazha P. Prakash ,  Punit P. Seth ,  Eric E. Swayze ,  Susan M. Freier ,  Mark J. Graham ,  Rosanne M. Crooke

IPC: C07H19/20 ,  C07H15/04

CPC classification number: C07H19/20 ,  C07H15/04 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/32 ,  C12N2310/3525 ,  C12N2310/3231

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids and/or glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease and/or metabolic disease, or a symptom thereof, in an individual in need thereof.

公开(公告)号：US09382505B2

公开(公告)日：2016-07-05

申请号：US14501909

申请日：2014-09-30

Applicant: Ecolab USA Inc.

Inventor： Charles Allen Hodge ,  Erin Jane Dahlquist ,  Amanda Ruth Blattner

IPC: C11D1/62 ,  C11D3/22 ,  C07H15/04 ,  C11D3/20 ,  C11D3/33

CPC classification number: C11D1/62 ,  C07H15/04 ,  C11D3/2003 ,  C11D3/227 ,  C11D3/33 ,  C11D11/0023

Abstract: A cleaning composition including a primarily C12 quaternary functionalized alkyl polyglucoside selected from the group consisting of stearyldimoniumhydroxypropyl laurylglucosides chloride and lauryldimoniumhydroxypropyl cocoglucosides chloride, a water conditioning agent, an acid source, a solvent, and water. In one embodiment, the cleaning composition is substantially free of alkyl phenol ethoxylates. The cleaning composition is capable of removing soils including up to 20% proteins. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food soils.

Abstract translation: 一种清洁组合物，其包含主要是C12季铵官能化的烷基聚葡萄糖苷，其选自硬脂基二甲基羟丙基月桂基葡糖苷氯化物和月桂基二甲基羟丙基葡糖苷氯化物，水调节剂，酸源，溶剂和水。 在一个实施方案中，清洁组合物基本上不含烷基酚乙氧基化物。 清洁组合物能够去除包括多达20％蛋白质的土壤。 清洁组合物包括生物可再生的，环保的壬基苯酚乙氧基化物的替代物，并且表现出优异的食品污垢清洁。