公开(公告)号：US20220244260A1

公开(公告)日：2022-08-04

申请号：US17616246

申请日：2020-06-04

Applicant: Cambridge Enterprise Limited

Inventor： Walid T. KHALED ,  Sara PENSA ,  Karsten BACH

IPC: G01N33/574 ,  C12Q1/6886 ,  C12Q1/6881 ,  G01N33/50

Abstract: The present invention relates to a method of assessing the likelihood of a subject having breast cancer or a precancerous condition associated with breast cancer. The present invention also relates to a method of determining whether treatment of breast cancer in a subject is required, and to a chemotherapeutic agent for use in the treatment of a subject in need of said treatment.

公开(公告)号：US11384127B2

公开(公告)日：2022-07-12

申请号：US17514822

申请日：2021-10-29

Applicant: Immatics Biotechnologies GmbH

Inventor： Andrea Mahr ,  Toni Weinschenk ,  Helen Hoerzer ,  Oliver Schoor ,  Jens Fritsche ,  Harpreet Singh

IPC: A61K39/00 ,  C07K14/47 ,  C12N15/115 ,  C07K7/08 ,  C07K7/06 ,  C07K16/28 ,  C12N5/0783 ,  A61K35/17 ,  C07K16/30 ,  C12P21/02 ,  C12Q1/6881 ,  G01N33/569 ,  C07K14/82 ,  C07K16/32 ,  C12Q1/6886 ,  G01N33/574 ,  C07K14/705 ,  C07K16/18 ,  C07K14/74 ,  A61K38/00 ,  A61K35/12

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US11352670B2

公开(公告)日：2022-06-07

申请号：US16880884

申请日：2020-05-21

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Jay Shendure ,  Matthew Snyder ,  Martin Kircher

IPC: C12Q1/6881 ,  G16H50/20 ,  G16B20/00 ,  G16B40/00 ,  G16B45/00 ,  G16B20/30 ,  G16B30/00 ,  G16B20/10 ,  G16B20/20 ,  G16B40/10 ,  C12Q1/6883 ,  C12Q1/6869

Abstract: The present disclosure provides methods of determining one or more tissues and/or cell-types contributing to cell-free DNA (“cfDNA”) in a biological sample of a subject. In some embodiments, the present disclosure provides a method of identifying a disease or disorder in a subject as a function of one or more determined more tissues and/or cell-types contributing to cfDNA in a biological sample from the subject.

公开(公告)号：US20220170101A1

公开(公告)日：2022-06-02

申请号：US17531364

申请日：2021-11-19

Applicant: iRepertoire, Inc.

Inventor： JIAN HAN

IPC: C12Q1/6883 ,  G16B20/00 ,  C12Q1/6881 ,  G01N33/68

Abstract: The present disclosure generally pertains to a method for developing diagnostic tests that are based on the immune response and the resulting immune repertoire. The presently disclosed method increases the signal and reduces the background to allow the identification of shared CDR3s that can be used to produce a disease signature. The presently disclosed method may be used to develop a diagnostic test for different diseases including, but not limited to, cancer, autoimmune disease, inflammatory disease and infectious disease.

公开(公告)号：US20220160854A1

公开(公告)日：2022-05-26

申请号：US17650360

申请日：2022-02-08

Applicant: Treos Bio Limited

Inventor： Levente Molnár ,  Eniko R. Toke ,  Julianna Lisziewicz ,  József Tóth ,  Orsolya Lorincz ,  Zsolt Csiszovszki ,  Eszter Somogyi ,  Katalin Pántya ,  Mónika Megyesi ,  Péter Páles

IPC: A61K39/00 ,  C07K16/28 ,  C07K14/74 ,  A61K39/39 ,  C12Q1/6881 ,  A61P37/04 ,  A61P35/00

Abstract: The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple alleles of receptors of the highest proportion of subjects in a target population.

公开(公告)号：US11306356B2

公开(公告)日：2022-04-19

申请号：US16306397

申请日：2017-06-01

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Jan Berka ,  Brian Godwin ,  Carolina Dallett ,  Sedide Ozturk ,  Joseph Platzer ,  Seoyoung Kim

IPC: C12Q1/6881 ,  C12Q1/68 ,  C40B50/06 ,  C12N15/10 ,  C12Q1/6886

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US20220098650A1

公开(公告)日：2022-03-31

申请号：US17538876

申请日：2021-11-30

Applicant: Murdoch Childrens Research Institute

Inventor： Howard Slater

IPC: C12Q1/6827 ,  C12Q1/6816 ,  C12Q1/6881 ,  C12Q1/6806

Abstract: Methods of measuring chimerism in a biological sample use informative copy number variations (CNV) in genetically distinct cell populations. Chimerism describes the co-existence of cells originating from more than one individual. Assessing CNV polymorphisms in genomic DNA provides a useful in-vitro method of measuring chimerism. The accuracy of the methods can be validated using an internal validation step.

公开(公告)号：US20220090217A1

公开(公告)日：2022-03-24

申请号：US17463824

申请日：2021-09-01

Applicant: Janssen Sciences Ireland Unlimited Company

Inventor： Marianne Isabelle TUEFFERD ,  Marjolein CRABBE ,  Jacques Armand Henri BOLLEKENS ,  Jeroen Marcel Maria Roger AERSSENS ,  Alessandro DI CARA

IPC: C12Q1/70 ,  C12Q1/6881

Abstract: Immunogenetic biomarkers of viral control of chronic hepatitis B (CHB) infection that are indicative of relapse after a viral suppression treatment, such as a NUC treatment, in CHB infected subject are described. Also described are methods and compositions of using the immunogenetic biomarkers in predicting the relapse in the viral suppression treatment of CHB infection.

公开(公告)号：US20220090196A1

公开(公告)日：2022-03-24

申请号：US17256390

申请日：2019-07-03

Applicant: Precision for Medicine GmbH

Inventor： Sven OLEK

IPC: C12Q1/6881

Abstract: The present invention relates to improved methods for epigenetic blood and immune cell detection and counting, and respective uses and kits.

公开(公告)号：US20220081678A1

公开(公告)日：2022-03-17

申请号：US17154117

申请日：2021-01-21

Applicant: HUNAN YUANPIN CELL TECHNOLOGY CO. LTD

Inventor： Zhigang Xue ,  Ning Yi ,  Lingbin Qi ,  Bo Lv ,  Chanyi Li ,  Chunbing Zheng ,  Weilin Li ,  Jiangzhou Hua ,  Tenglong Yan ,  Yuan Yang

IPC: C12N5/0775 ,  A61K35/28 ,  C12Q1/6881 ,  A61K9/00

Abstract: The present disclosure provides the use of mesenchymal stem cells (MSC) in the treatment of viral infection and/or complications caused by the viral infection. MSC can highly express multiple antioxidative stress genes and secrete multiple antioxidative stress factors under the stimulation of oxidative stress, inhibit inflammatory reaction and excessive activation of immune cells, thus improving inflammatory indexes and myocardial injury indexes of human bodies. MSC can regulate the expression profile of monocyte genes and monocyte toxicity genes in patients with viral infection, inhibit the excessive immune response, protect alveolar function, and reduce the damage of lung and whole body organs in patients with viral infection. MSC can regulate the expression of antivirus-related genes and coagulation-related genes of terminally differentiated cell subsets in patients with viral infection, inhibit the excessive activation of monocytes in patients with viral infection, and effectively treat the complications of patients with viral infection.