公开(公告)号：US20180153177A1

公开(公告)日：2018-06-07

申请号：US15886791

申请日：2018-02-01

申请人： The Trustees of Columbia University in the City of New York

发明人： Shanta M. Modak ,  Arnab Kumar Ghosh ,  Lauserpina Caraos

IPC分类号： A01N65/44 ,  A61K36/28 ,  A01N65/00 ,  A61K8/365 ,  A61K8/41 ,  A61K31/05 ,  A61K36/185 ,  A61K8/60 ,  C02F3/32 ,  A61K9/06 ,  A01N65/06 ,  A61K36/15 ,  A01N65/36 ,  A61K31/14 ,  A61K31/085 ,  A01N47/44 ,  A61K31/4425 ,  A61Q17/00 ,  A01N25/16 ,  A61K9/00 ,  A61K36/899

CPC分类号： A01N65/44 ,  A01N25/16 ,  A01N31/02 ,  A01N31/08 ,  A01N31/12 ,  A01N31/14 ,  A01N33/12 ,  A01N47/44 ,  A01N65/00 ,  A01N65/06 ,  A01N65/22 ,  A01N65/36 ,  A61K8/34 ,  A61K8/345 ,  A61K8/347 ,  A61K8/365 ,  A61K8/368 ,  A61K8/416 ,  A61K8/43 ,  A61K8/60 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/047 ,  A61K31/05 ,  A61K31/085 ,  A61K31/14 ,  A61K31/155 ,  A61K31/4425 ,  A61K31/60 ,  A61K36/15 ,  A61K36/185 ,  A61K36/28 ,  A61K36/53 ,  A61K36/752 ,  A61K36/80 ,  A61K36/886 ,  A61K36/898 ,  A61K36/899 ,  A61K36/9066 ,  A61K2800/30 ,  A61K2800/592 ,  A61Q11/00 ,  A61Q17/005 ,  A61Q19/10 ,  C02F3/327 ,  C02F2103/005 ,  C02F2303/04 ,  C11D3/48 ,  A61K2300/00 ,  A01N37/36

摘要： Disclosed herein are antimicrobial compositions comprising mixtures of botanical extracts, synthetic antimicrobial agents and essential oils which do not rely solely upon alcohol to produce their antimicrobial effects.

公开(公告)号：US09981048B2

公开(公告)日：2018-05-29

申请号：US14177928

申请日：2014-02-11

申请人： University of Pittsburgh—of the Commonwealth System of Higher Education

发明人： Ira Jacob Fox ,  Aaron W. Bell ,  Taichiro N. Nishikawa ,  Alejandro Soto-Gutierrez ,  Yoram Vodovotz

IPC分类号： A61K48/00 ,  A61K31/343 ,  C07K14/47 ,  A61K45/06 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  C12N15/86

CPC分类号： A61K48/005 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61K31/343 ,  A61K45/06 ,  C07K14/4702 ,  C12N15/86 ,  C12N2750/14141 ,  C12N2750/14171 ,  A61K2300/00

摘要： The presently disclosed invention is directed to the discovery that hepatocyte nuclear factor 4 alpha (HNF4α; also known as NR2A1), a transcription factor, reverses hepatocyte dysfunction in an animal model of cirrhosis, resulting in improvement in hepatic function, treatment of cirrhosis, and prolonged survival.

公开(公告)号：US09925153B2

公开(公告)日：2018-03-27

申请号：US15036968

申请日：2014-12-05

申请人： STC.UNM

发明人： David L Vander Jagt ,  Lorraine M Deck ,  Robert E Royer ,  John E Heidrich

IPC分类号： A61K31/085 ,  A61K31/12 ,  A61K45/06 ,  A61K31/09 ,  A61K31/121 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K9/00 ,  A61K31/05 ,  A61K31/136 ,  A61K31/444

CPC分类号： A61K31/12 ,  A61K9/0014 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/121 ,  A61K31/136 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/444 ,  A61K45/06

摘要： The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.

公开(公告)号：US20180049996A1

公开(公告)日：2018-02-22

申请号：US15787999

申请日：2017-10-19

申请人： NIPPON HYPOX LABORATORIES INCORPORATED

发明人： Tokutaro Miki ,  Hiroshi Nishikawa ,  Jong-Koo Kang ,  Satoru Sugiyama

IPC分类号： A61K31/085 ,  A61K31/222

CPC分类号： A61K31/085 ,  A61K31/222

摘要： A novel agent which is effective in the prevention or treatment of a chronic respiratory disease such as COPD, interstitial pneumonia and asthma is provided. The therapeutic agent for a chronic respiratory disease comprises, as an active ingredient, a hydroquinone derivative represented by general formula (1) wherein R1 represents an alkyl group having 4 to 8 carbon atoms, and R2 represents a hydrogen atom, an alkylcarbonyl group having 2 to 6 carbon atoms or an alkoxycarbonyl group having 2 to 6 carbon atoms.

公开(公告)号：US20170348295A1

公开(公告)日：2017-12-07

申请号：US15456561

申请日：2017-03-12

申请人： SIRGA ADVANCED BIOPHARMA INC

发明人： Franck Vendeix ,  Paul F. Agris

IPC分类号： A61K31/445 ,  A61K31/085 ,  A61K31/5377 ,  A61K31/53 ,  A61K31/519 ,  A61K31/517 ,  A61K31/4745 ,  A61K31/473 ,  A61K31/47 ,  A61K31/4468 ,  A61K31/4453 ,  A61K31/44 ,  A61K31/428 ,  A61K31/427 ,  A61K31/37 ,  A61K31/222 ,  A61K31/18 ,  A61K31/136 ,  A61K31/55 ,  A61K31/63

CPC分类号： A61K31/445 ,  A61K31/085 ,  A61K31/136 ,  A61K31/18 ,  A61K31/222 ,  A61K31/37 ,  A61K31/427 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4453 ,  A61K31/4468 ,  A61K31/47 ,  A61K31/473 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/63

摘要： Disclosed herein are compounds, compositions and methods of their use to treat HIV/AIDS disease in a subject in need thereof, wherein the compositions comprise small molecule inhibitors that inhibit viral preparation or viral recruitment of human tRNA3Lys.

公开(公告)号：US09809521B2

公开(公告)日：2017-11-07

申请号：US15005952

申请日：2016-01-25

申请人： Sutter West Bay Hospitals

发明人： Sean D. McAllister ,  Pierre-Yves Desprez ,  Anuradha Mahadevan

IPC分类号： C07C39/42 ,  A61K31/05 ,  A61K45/06 ,  A61K31/352 ,  C07C39/10 ,  C07C43/21 ,  A61K31/085 ,  C07D295/096 ,  A61K31/495 ,  C07D295/30 ,  C07C69/017 ,  C07C271/44 ,  C07D213/80 ,  C07F9/09 ,  C07C309/17 ,  C07F9/12 ,  A61K31/337 ,  A61K31/4188 ,  C07C69/16 ,  C07C69/40 ,  C07C39/17 ,  C07C39/23 ,  C07C43/23

CPC分类号： C07C39/42 ,  A61K31/05 ,  A61K31/085 ,  A61K31/337 ,  A61K31/352 ,  A61K31/4188 ,  A61K31/495 ,  A61K45/06 ,  C07C39/10 ,  C07C39/17 ,  C07C39/23 ,  C07C43/21 ,  C07C43/23 ,  C07C69/017 ,  C07C69/16 ,  C07C69/40 ,  C07C271/44 ,  C07C309/17 ,  C07C2601/14 ,  C07C2601/16 ,  C07D213/80 ,  C07D295/096 ,  C07D295/30 ,  C07F9/09 ,  C07F9/12 ,  A61K2300/00

摘要： The disclosure relates to cannabinoid derivative compounds, pharmaceutical compositions made thereof, and methods for treating various diseases and disorders including cancer.

公开(公告)号：US20170304218A1

公开(公告)日：2017-10-26

申请号：US15521540

申请日：2015-10-23

申请人： LAUNX BIOMEDICAL CO., LTD.

发明人： Chiu-Hung Chen ,  Show-Mei Chuang ,  Tzong-Der Way ,  Nai-Wan Hsiao

IPC分类号： A61K31/085

CPC分类号： A61K31/381 ,  A61K31/00 ,  A61K31/085 ,  A61K31/137 ,  A61K31/138 ,  A61K31/196 ,  A61K31/197 ,  A61K31/216 ,  A61K31/341 ,  A61K31/366 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/4525 ,  A61K31/505 ,  A61K31/549 ,  A61K31/55 ,  A61K31/7056 ,  A61K38/00 ,  A61K38/02 ,  A61K38/05 ,  A61K38/14 ,  A61K45/06 ,  A61K2300/00 ,  C07C211/27 ,  C07C211/30

摘要： A method for treating a cancer includes administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising Monobenzone or a pharmaceutical acceptable salt thereof. The cancer is selected from pleural-related cancer, abdominal-related cancer, endocrine-related cancer, gastrointestinal tract-related cancer, osteosarcoma, and skin cancer. The pleural-related cancer is lung cancer. The abdominal-related cancer is selected from bladder cancer, cervical cancer, and kidney cancer. The endocrine-related cancer is selected from prostate cancer, breast cancer, and ovarian cancer. The gastrointestinal tract-related cancer is selected from gastric cancer, hepatic cancer, colorectal cancer, pancreatic cancer, and tongue cancer.

公开(公告)号：US09789099B2

公开(公告)日：2017-10-17

申请号：US14433455

申请日：2013-09-10

申请人： Beiersdorf AG

发明人： Gitta Neufang ,  Torsten Schlaeger ,  Nadine Voigt ,  Anne-Christin Worthmann

IPC分类号： A61K31/045 ,  A61K31/075 ,  A61K31/4402 ,  A61K9/00 ,  A61K47/10 ,  A61K45/06 ,  A61K31/085 ,  A61K31/11 ,  A61K31/12 ,  A61K31/166 ,  A61K31/215 ,  A61K31/22 ,  A61K9/06

CPC分类号： A61K31/4402 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/045 ,  A61K31/075 ,  A61K31/085 ,  A61K31/11 ,  A61K31/12 ,  A61K31/166 ,  A61K31/215 ,  A61K31/22 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00

摘要： Agonists for the TRPM-8 receptor, more particularly one or more substances selected from the group of, for example, linalool, geraniol, hydroxycitronellal, WS-3 (N-ethyl-p-menthane-3-carboxamide), WS-23 (2-isopropyl-N,2,3-trimethylbutyramide), Frescolat MAG (1,4-dioxaspiro[4.5]decane-2-methanol), Frescolat ML (menthyl lactate), Coolact P (5-methyl-2-prop-1-en-2-ylcyclohexan-1-ol) and Cooling Agent 10 (menthoxypropanediol), for use as medicaments to counter atopic dermatitis.

公开(公告)号：US20170290776A1

公开(公告)日：2017-10-12

申请号：US15587376

申请日：2017-05-04

申请人： MONOSOL RX, LLC

发明人： Alexander Mark Schobel ,  Stephanie Marie Varjan ,  Stephen Paul Wargacki

IPC分类号： A61K9/70 ,  A61K31/085 ,  A61K31/05 ,  A61K31/36 ,  A61K47/38 ,  A61M35/00 ,  A61K31/5517 ,  A61K31/137 ,  A61K47/32 ,  A61K47/10 ,  A61K47/14 ,  A61K36/61 ,  A61K47/12

CPC分类号： A61K9/7007 ,  A61K9/006 ,  A61K31/05 ,  A61K31/085 ,  A61K31/137 ,  A61K31/36 ,  A61K31/5513 ,  A61K31/5517 ,  A61K36/61 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/38 ,  A61K47/46 ,  A61M35/003

摘要： Pharmaceutical compositions having enhanced active component permeation properties are described.

公开(公告)号：US09693973B2

公开(公告)日：2017-07-04

申请号：US14604949

申请日：2015-01-26

申请人： Inge Kruse ,  Thomas Raschke ,  Jens-Peter Vietzke ,  Julia Eckert

发明人： Inge Kruse ,  Thomas Raschke ,  Jens-Peter Vietzke ,  Julia Eckert

IPC分类号： A61K31/075 ,  A61K31/12 ,  A61K36/484 ,  A61K31/47 ,  A61K31/085 ,  A61K8/35 ,  A61K8/97 ,  A61Q19/00 ,  A61Q19/08 ,  A61K8/34 ,  A61K31/047

CPC分类号： A61K31/12 ,  A61K8/34 ,  A61K8/345 ,  A61K8/35 ,  A61K8/97 ,  A61K31/047 ,  A61K31/075 ,  A61K31/085 ,  A61K36/484 ,  A61Q19/00 ,  A61Q19/005 ,  A61Q19/007 ,  A61Q19/08 ,  A61K2300/00

摘要： Disclosed is a method for the treatment or prophylaxis of an inflammatory skin condition with cosmetic or pharmaceutical preparation which comprises licochalcone A and phenoxyethanol.