公开(公告)号：US07357915B2

公开(公告)日：2008-04-15

申请号：US10210986

申请日：2002-08-02

Applicant: Francis G. Blankenberg ,  H. W. Strauss ,  Jonathan F. Tait ,  Peter D. Katsikis

Inventor： Francis G. Blankenberg ,  H. W. Strauss ,  Jonathan F. Tait ,  Peter D. Katsikis

IPC: A61K51/08 ,  A61K49/00 ,  A61K103/00 ,  G01N33/567 ,  G01N33/532

CPC classification number: A61K51/088 ,  A61B6/037 ,  A61B6/4057 ,  A61B6/425 ,  A61B6/4258 ,  A61K51/087

Abstract: A method of imaging apoptosis in vivo, using radiolabeled annexin, is described.

Abstract translation: 描述了使用放射性标记的膜联蛋白在体内成像凋亡的方法。

公开(公告)号：US07026623B2

公开(公告)日：2006-04-11

申请号：US10752978

申请日：2004-01-07

Applicant: Jacob Oaknin ,  Shoulamit C. Shwartz ,  Israel Ohana

Inventor： Jacob Oaknin ,  Shoulamit C. Shwartz ,  Israel Ohana

IPC: G01T1/166

CPC classification number: G06T11/006 ,  A61B6/037 ,  A61B6/4057 ,  A61B6/503 ,  A61B6/541 ,  A61B6/583 ,  G01T1/1644 ,  G06T2211/424

Abstract: A method of diagnostic imaging in a shortened acquisition time for obtaining a reconstructed diagnostic image of a portion of a body of a human patient who was administered with dosage of radiopharmaceutical substance radiating gamma rays, using SPECT. The method comprises acquiring photons emitted from said portion of the body, by means of a detector capable of converting the photons into electric signals, wherein the total time of photon acquiring is substantially shorter than the clinically acceptable acquisition time; processing said electric signals by a position logic circuitry and thereby deriving data indicative of positions on said photon detector crystal, where the photons have impinged the detector; andreconstructing an image of a spatial distribution of the pharmaceutical substance within the portion of the body by iteratively processing said data.

Abstract translation: 一种缩短采集时间的诊断成像方法，用于获得使用SPECT辐射伽马射线的放射性药物物质的剂量的人体患者身体的一部分的重建诊断图像。 该方法包括通过能够将光子转换为电信号的检测器来获取从身体的所述部分发射的光子，其中光子获取的总时间明显短于临床可接受的获取时间; 通过位置逻辑电路处理所述电信号，从而导出指示所述光子检测器晶体上的位置的数据，其中光子已经撞击了检测器; 以及通过迭代地处理所述数据来重建身体部分内的药物的空间分布的图像。

公开(公告)号：US06331703B1

公开(公告)日：2001-12-18

申请号：US09266961

申请日：1999-03-12

Applicant: Stephen T. Yarnall ,  Mark W. DiFrancesco

Inventor： Stephen T. Yarnall ,  Mark W. DiFrancesco

IPC: A61B502

CPC classification number: A61B6/4057 ,  A61B6/425 ,  A61B6/4258

Abstract: A non-linear guidance method for radiation detection is described herein wherein a heuristic non-linear radiation detection method is utilized is for the location of sentinel nodes for staging cancer. The method of radiation detection described herein includes the steps of: Generating radiation decay rate counts wherein the counts are a sum of detected radiation decay events over a time interval; loading the counts into an array; summing selected elements of the array to generate a total count and a plurality of candidate counts; comparing the total count to one of the candidate counts to determine whether the one of the candidate counts is statistically different from the total count; using the statistically different one of the candidate counts as an output count rate; and generating an output signal using the output count rate to determine the characteristics of the output signal.

Abstract translation: 本文描述了用于放射线检测的非线性引导方法，其中利用启发式非线性辐射检测方法是用于分期癌症的前哨淋巴结的位置。 本文描述的辐射检测方法包括以下步骤：产生辐射衰减速率计数，其中计数是在时间间隔内检测到的辐射衰减事件的总和; 将计数加载到数组中; 对阵列的所选择的元素求和以产生总计数和多个候选计数; 将总计数与候选计数之一进行比较，以确定候选计数中的一个是否在统计学上与总计数不同; 使用统计上不同的一个候选计数作为输出计数率; 以及使用所述输出计数率产生输出信号以确定所述输出信号的特性。

公开(公告)号：US5961457A

公开(公告)日：1999-10-05

申请号：US642840

申请日：1996-05-03

Applicant: Raymond R. Raylman ,  Richard L. Wahl

Inventor： Raymond R. Raylman ,  Richard L. Wahl

IPC: A61B6/00 ,  A61B10/00 ,  A61B10/02

CPC classification number: A61B6/4057 ,  A61B6/4258 ,  A61B10/02 ,  A61B6/583

Abstract: A medical method and apparatus for the localization and biospy of lesions in a patient body part. A radiopharmaceutical is administered to the patient followed by placement of the body part within a scanner for obtaining emission data. The emission data is converted into Cartesian coordinates which are used to guide a sampling instrument for the biopsy of said lesion.

Abstract translation: 用于患者身体部位的病变局部化和生物周期性的医疗方法和装置。 向患者施用放射性药物，然后将身体部位放置在扫描器内以获得排放数据。 发射数据被转换成笛卡尔坐标，用于引导用于所述病变活检的采样仪器。

公开(公告)号：US5331961A

公开(公告)日：1994-07-26

申请号：US853622

申请日：1992-03-19

Applicant: Makoto Inaba ,  Masakazu Gotanda ,  Hiromu Takahashi ,  Takashi Nakamura ,  Masatoshi Itoh ,  Masaki Matsumoto ,  Hiroshi Watabe

Inventor： Makoto Inaba ,  Masakazu Gotanda ,  Hiromu Takahashi ,  Takashi Nakamura ,  Masatoshi Itoh ,  Masaki Matsumoto ,  Hiroshi Watabe

IPC: A61B10/00 ,  A61B6/00 ,  G01T1/161

CPC classification number: A61B6/4057 ,  A61B6/425 ,  A61B6/4258 ,  G01T1/161

Abstract: In a probe, two scintillators are arranged in tandem, the front end surfaces of two optical fibers transmitting the light emitted by the scintillators are connected to the rear of the scintillators and two photoelectric converters converting the light to pulse signals are connected to the rear of the optical fibers. A gate delay generator produces a gate signal from one pulse signal. A delay amplifier delays the other pulse signal. An M.C.A. will count up in case the pulse signal output by the delay amplifier is obtained during the gate signal.

Abstract translation: 在探头中，串联布置两个闪烁体，将由闪烁体发射的光的两根光纤的前端表面连接到闪烁体的后部，并将两个将光转换成脉冲信号的光电转换器连接到 光纤。 门延迟发生器从一个脉冲信号产生门信号。 延迟放大器延迟另一个脉冲信号。 一个M.C.A. 在门信号期间获得由延迟放大器输出的脉冲信号的情况下将计数。

公开(公告)号：US5119818A

公开(公告)日：1992-06-09

申请号：US557343

申请日：1990-07-25

Applicant: Robert G. Carroll ,  Robin A. Wise, Jr.

Inventor： Robert G. Carroll ,  Robin A. Wise, Jr.

IPC: A61B6/00 ,  A61B10/00 ,  A61B10/02 ,  A61B17/34 ,  A61B19/00 ,  G01T1/161

CPC classification number: A61B10/0233 ,  A61B17/3403 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4423 ,  G01T1/161 ,  A61B2017/00902

Abstract: A biopsy probe for detecting radiation emanating from a hidden source in a patient. The probe comprises a body member formed of a radiation blocking material and having a distal end portion and a proximal end portion. The proximal end portion is arranged to be held in the hand of a user. The probe comprises a radiation detector, e.g., a scintillation crystal, located within the distal portion of body member, a first radiation transparent window located at the distal end of the body member confronting the detector and through which radiation may pass to the detector, and a passageway extending through the distal end portion of the body member centered in the window and the detecting means. The passageway is arranged to guide a thin instrument, e.g., a biopsy needle, therethrough when the distal end portion is oriented in a direction toward the hidden source of radiation. A disposable cover/shield is also provided for releasable securement to the distal end of the probe to protect it from contamination. A collimator is also provided for releasable securement to the probe to reduce the probe's field of view.

Abstract translation: 用于检测患者隐藏源发出的放射线的活检探针。 探针包括由辐射阻挡材料形成并具有远端部分和近端部分的主体部件。 近端部分被布置成保持在使用者的手中。 探针包括放射线检测器，例如闪烁晶体，其位于主体构件的远端部分内，第一辐射透明窗口，位于身体构件的远端处，与检测器相对，并且辐射可以通过该检测器传递到检测器;以及 延伸穿过位于窗口中心的身体构件的远端部分的通道和检测装置。 当远端部分朝向隐藏的辐射源的方向定向时，该通道被布置成引导诸如活检针的薄器械穿过其中。 还提供一次性盖/护罩用于可释放地固定在探针的远端，以防止其受到污染。 还提供准直器用于可释放地固定到探头以减小探头的视野。

公开(公告)号：US4660563A

公开(公告)日：1987-04-28

申请号：US775093

申请日：1985-09-11

Applicant: Robert S. Lees

Inventor： Robert S. Lees

IPC: A61B6/00 ,  A61K51/12

CPC classification number: A61B6/4057 ,  A61B6/4258 ,  A61K51/1224 ,  A61K2123/00

Abstract: The atherosclerotic plaques which form arterial lesions have been found to take up lipoproteins from the blood flowing through the arteries. Accordingly, the early detection of arterial disease is accomplished by preparing an infusate composed of radiolabeled low-density lipoproteins and introducing the infusate into the patient's arterial system. A gamma radiation detector is then used to detect and quantify concentrations of the radiolabeled proteins thereby to indicate the locations and sizes of the lesions.

Abstract translation: 已经发现形成动脉损伤的动脉粥样硬化斑块从流经动脉的血液中摄取脂蛋白。 因此，动脉疾病的早期检测是通过制备由放射性标记的低密度脂蛋白组成的灌注液并将输注物引入患者的动脉系统来完成的。 然后使用γ辐射检测器来检测和定量放射性标记的蛋白质的浓度，从而指示病变的位置和大小。

公开(公告)号：US4404973A

公开(公告)日：1983-09-20

申请号：US255895

申请日：1981-04-20

Applicant: Jack Lancaster ,  John Floyd ,  William Harvey

Inventor： Jack Lancaster ,  John Floyd ,  William Harvey

IPC: A61B6/00 ,  G01T1/161 ,  G06F17/00 ,  A61G5/02

CPC classification number: G01T1/161 ,  A61B6/4057 ,  A61B6/4258

Abstract: A method and apparatus for evaluating the condition of the heart muscle utilizing a single roughly collimated radiation detector which is non-critically positioned over the heart muscle. A small amount of radioactive material is injected into the bloodstream and detected during the first transit through the heart. The background radiation level is empirically derived from, and may be utilized to correct, the aforementioned first transit data. Numerous parameters affecting the heart muscle may be determined by analysis of the resultant data.

Abstract translation: 一种用于使用非关键定位在心脏肌肉上的单个大致准直的放射线检测器来评估心肌的状况的方法和装置。 少量的放射性物质注入血液中，并在首次通过心脏途中检测到。 背景辐射水平经验地来自并且可以用于校正上述第一过境数据。 可以通过分析所得数据来确定影响心脏肌肉的许多参数。

公开(公告)号：US4111191A

公开(公告)日：1978-09-05

申请号：US487425

申请日：1974-07-10

Applicant: Robert F. Shaw

Inventor： Robert F. Shaw

IPC: A61B6/00 ,  G01T1/164 ,  G06F19/00 ,  A61B5/02

CPC classification number: G01T1/1647 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/507 ,  G06F19/3487

Abstract: The extent, location, and severity of stenotic atherosclerotic lesions in the coronary arteries are determined by intravenous injection into the circulating blood of a number of small, discrete positron-emitting particles and by tracking the particles in three dimensions in the region of the heart using suitable gamma detectors disposed external to the patient's chest. The resolution and counting rates of the gamma detectors permit the sequence of positions of each particle to be recorded as a function of time as each particle flows through a coronary vessel. Data analysis of these recordings of particle position provide information about the velocity of blood flow through the course of each coronary artery. This velocity information is used to determine the extent, severity, and location of stenotic lesions of the coronary arteries.

公开(公告)号：US3970853A

公开(公告)日：1976-07-20

申请号：US585625

申请日：1975-06-10

Applicant: David E. Kuhl ,  Roy Q. Edwards

Inventor： David E. Kuhl ,  Roy Q. Edwards

IPC: G01T1/161 ,  A61B6/00 ,  G01T1/29 ,  G01T1/20

CPC classification number: A61B6/56 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/548 ,  G01T1/2985

Abstract: This invention provides a transverse section radionuclide scanning system for high-sensitivity quantification of brain radioactivity in cross-section picture format in order to permit accurate assessment of regional brain function localized in three-dimensions. High sensitivity crucially depends on overcoming the heretofore known raster type scanning, which requires back and forth detector movement involving dead-time or partial enclosure of the scan field. Accordingly, this invention provides a detector array having no back and forth movement by interlaced detectors that enclose the scan field and rotate as an integral unit around one axis of rotation in a slip ring that continuously transmits the detector data by means of laser emitting diodes, with the advantages that increased amounts of data can be continuously collected, processed and displayed with increased sensitivity according to a suitable computer program.

Abstract translation: 本发明提供横截面放射性核素扫描系统，用于高分辨率定量横截面图像格式的脑放射性，以便准确评估三维局部区域性脑功能。 高灵敏度至关重要地取决于克服迄今为止已知的光栅类型扫描，其需要来回检测器移动，涉及扫描场的死区或部分封闭。 因此，本发明提供了一种检测器阵列，其不需要通过交错检测器进行前后移动，该检测器包围扫描场并围绕滑环中的一个旋转轴旋转，作为整体单元，其通过激光发射二极管连续传输检测器数据， 具有根据合适的计算机程序可以以增加的灵敏度连续收集，处理和显示增加数据量的优点。