公开(公告)号：US07780973B2

公开(公告)日：2010-08-24

申请号：US10736421

申请日：2003-12-15

Applicant: Lynetta Jean Freeman ,  Mark W. DiFrancesco

Inventor： Lynetta Jean Freeman ,  Mark W. DiFrancesco

IPC: A61F2/02

CPC classification number: A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/00

Abstract: A minimally invasive method of placing a delivery device substantially adjacent to vascular tissue and a device for use with such a method are disclosed. The delivery device may be a flexible biological construct with a flexible tethering means. The delivery device may be percutaneously inserted near vascular tissue such as, for example, peritoneal tissue. When the delivery device has been inserted, the tether may be used to pull the delivery device toward the vascular tissue and secure the device thereto. Contact between the front surface of the delivery device and the vascular tissue may be maintained by making and keeping the tether substantially taut. The delivery device may serve accomplish sustained delivery of active agents.

Abstract translation: 公开了一种将输送装置放置在基本上邻近于血管组织的微创方法和用于这种方法的装置。 递送装置可以是具有柔性束缚装置的柔性生物构建体。 递送装置可以经皮插入血管组织附近，例如腹膜组织。 当输送装置被插入时，系绳可以用于将输送装置拉向血管组织并将装置固定到其上。 输送装置的前表面和血管组织之间的接触可以通过使系统基本拉紧并保持。 递送装置可以实现活性剂的持续递送。

公开(公告)号：US06331703B1

公开(公告)日：2001-12-18

申请号：US09266961

申请日：1999-03-12

Applicant: Stephen T. Yarnall ,  Mark W. DiFrancesco

Inventor： Stephen T. Yarnall ,  Mark W. DiFrancesco

IPC: A61B502

CPC classification number: A61B6/4057 ,  A61B6/425 ,  A61B6/4258

Abstract: A non-linear guidance method for radiation detection is described herein wherein a heuristic non-linear radiation detection method is utilized is for the location of sentinel nodes for staging cancer. The method of radiation detection described herein includes the steps of: Generating radiation decay rate counts wherein the counts are a sum of detected radiation decay events over a time interval; loading the counts into an array; summing selected elements of the array to generate a total count and a plurality of candidate counts; comparing the total count to one of the candidate counts to determine whether the one of the candidate counts is statistically different from the total count; using the statistically different one of the candidate counts as an output count rate; and generating an output signal using the output count rate to determine the characteristics of the output signal.

Abstract translation: 本文描述了用于放射线检测的非线性引导方法，其中利用启发式非线性辐射检测方法是用于分期癌症的前哨淋巴结的位置。 本文描述的辐射检测方法包括以下步骤：产生辐射衰减速率计数，其中计数是在时间间隔内检测到的辐射衰减事件的总和; 将计数加载到数组中; 对阵列的所选择的元素求和以产生总计数和多个候选计数; 将总计数与候选计数之一进行比较，以确定候选计数中的一个是否在统计学上与总计数不同; 使用统计上不同的一个候选计数作为输出计数率; 以及使用所述输出计数率产生输出信号以确定所述输出信号的特性。