公开(公告)号：US20080058916A1

公开(公告)日：2008-03-06

申请号：US11444843

申请日：2006-05-31

申请人： Bin Huang ,  David C. Gale

发明人： Bin Huang ,  David C. Gale

IPC分类号： A61F2/06 ,  B05D1/12

CPC分类号： A61F2/90 ,  A61F2210/0004

摘要： A method of manufacturing a radially expandable an implantable medical device, the method comprising: providing a plurality of fibers, the fibers comprising a polymer; disposing the plurality of fibers on a cylindrical support element to form a tubular structure, the tubular structure having an initial diameter; heat setting the tubular structure such that the temperature of the tubular structure is between Tg to Tm of the polymer while heat setting, wherein the tubular structure is maintained at a heat set diameter which is equal to or substantially equal to the initial diameter; and fabricating an implantable medical device from the tubular structure.

摘要翻译： 一种制造可径向扩张的可植入医疗装置的方法，所述方法包括：提供多根纤维，所述纤维包括聚合物; 将所述多个纤维布置在圆柱形支撑元件上以形成管状结构，所述管状结构具有初始直径; 热定形管状结构，使得管状结构的温度在热定形时在聚合物的Tg至Tm之间，其中管状结构保持在等于或基本等于初始直径的热定形直径; 以及从所述管状结构制造可植入医疗装置。

公开(公告)号：US20080021307A1

公开(公告)日：2008-01-24

申请号：US11486688

申请日：2006-07-13

申请人： Abigail Freeman ,  David C. Gale ,  Bin Huang ,  Daniel Castro

发明人： Abigail Freeman ,  David C. Gale ,  Bin Huang ,  Daniel Castro

IPC分类号： A61B5/05

CPC分类号： G01N25/72 ,  A61B90/90 ,  A61B90/98 ,  A61F2/06 ,  A61F2/82 ,  A61F2250/0085 ,  A61L2/081 ,  A61L2/082 ,  A61L2/085 ,  A61L2/087 ,  A61L2/10 ,  A61L2202/14

摘要： A method and system of monitoring environmental exposure of stents using radiofrequency identification is disclosed.

摘要翻译： 公开了使用射频识别来监测支架的环境暴露的方法和系统。

公开(公告)号：US20080009938A1

公开(公告)日：2008-01-10

申请号：US11483040

申请日：2006-07-07

申请人： Bin Huang ,  David C. Gale

发明人： Bin Huang ,  David C. Gale

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91566 ,  A61F2230/0013 ,  A61F2250/0098

摘要： A stent includes a marker that has a biodegradable body and a plurality of radiopaque nanoparticles dispersed in the body. The marker is disposed in a hole on a biodegradable structural element of the stent, and the marker and the hole have substantially the same configuration. A method for making a stent includes mixing radiopaque nanoparticles with a biodegradable material to form a stent marker, forming a hole on a structural element of a biodegradable stent for accommodating the stent marker, wherein the stent marker and hole have substantially the same configuration, and disposing the stent marker in the hole.

摘要翻译： 支架包括具有可生物降解的身体和分散在体内的多个不透射线的纳米颗粒的标记物。 标记物设置在支架的可生物降解的结构元件的孔中，并且标记和孔具有基本相同的构造。 制造支架的方法包括将不透射线的纳米颗粒与可生物降解材料混合以形成支架标记，在用于容纳支架标记的可生物降解支架的结构元件上形成孔，其中支架标记和孔具有基本相同的构造，以及 将支架标记物放置在孔中。

公开(公告)号：US07229471B2

公开(公告)日：2007-06-12

申请号：US10937975

申请日：2004-09-10

申请人： David C. Gale ,  Klaus Kleine ,  Anthony J. Abbate ,  Svava Maria Atladottir ,  Stephen D. Pacetti

发明人： David C. Gale ,  Klaus Kleine ,  Anthony J. Abbate ,  Svava Maria Atladottir ,  Stephen D. Pacetti

IPC分类号： A61F2/06 ,  A61M29/00

CPC分类号： A61L31/141

摘要： Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.

公开(公告)号：US09248034B2

公开(公告)日：2016-02-02

申请号：US11210344

申请日：2005-08-23

申请人： Syed F. A. Hossainy ,  David C. Gale ,  Florian N. Ludwig

发明人： Syed F. A. Hossainy ,  David C. Gale ,  Florian N. Ludwig

IPC分类号： A61F2/06 ,  A61F2/82 ,  A61L31/14 ,  A61L31/16 ,  A61F2/91

CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/622

摘要： Implantable medical devices for treating bodily disorders local and distally to a region of implantation are disclosed. The devices include a body structure including an active agent, erodable particles acting as a carrier of the active agent, and an erodable binder. The binder releasably binds the particles together such that after implantation the binder erodes to release the particles.

摘要翻译： 公开了用于治疗局部和远端到植入区域的身体障碍的可植入医疗装置。 这些装置包括主体结构，其包括活性剂，作为活性剂的载体的可侵蚀颗粒和可侵蚀的粘合剂。 粘合剂将颗粒可释放地结合在一起，使得在植入之后，粘合剂侵蚀以释放颗粒。

公开(公告)号：US08795030B2

公开(公告)日：2014-08-05

申请号：US12902082

申请日：2010-10-11

申请人： Bin Huang ,  David C. Gale ,  Daniel Castro ,  Timothy Limon

发明人： Bin Huang ,  David C. Gale ,  Daniel Castro ,  Timothy Limon

IPC分类号： A61F2/07 ,  A61F2/82

CPC分类号： A61F2/82 ,  A61F2/91 ,  A61L2400/18 ,  C08J7/02

摘要： Methods of treating the polymeric surfaces of a stent with a fluid including a solvent for the surface polymer are disclosed.

摘要翻译： 公开了一种用包括用于表面聚合物的溶剂的流体处理支架的聚合物表面的方法。

公开(公告)号：US08763222B2

公开(公告)日：2014-07-01

申请号：US12512855

申请日：2009-07-30

申请人： Anthony J. Abbate ,  Bin Huang ,  Gail M. Zaler ,  David C. Gale ,  Richard E. Kaufman ,  Vijaykumar Rajasekhar

发明人： Anthony J. Abbate ,  Bin Huang ,  Gail M. Zaler ,  David C. Gale ,  Richard E. Kaufman ,  Vijaykumar Rajasekhar

IPC分类号： B23P19/00 ,  B25B27/10 ,  A61F2/95 ,  A61F2/00 ,  A61F2/24

CPC分类号： A61F2/95 ,  A61F2/0095 ,  A61F2/24 ,  A61F2002/9511 ,  A61F2002/9522 ,  B25B27/10 ,  Y10T29/49908 ,  Y10T29/53657 ,  Y10T29/53709 ,  Y10T29/53783 ,  Y10T29/53991

摘要： Described here are devices and methods for crimping self-expanding devices. The crimping devices may be useful for crimping a variety of different self-expanding devices (whether such devices are biodegradable or bio-durable). The crimping devices may have crimping members to engage the self-expanding device to reduce the device from an expanding configuration to an unexpanded configuration. The crimping member may comprise or include a suture, wire, ribbon, guiding hoop, pusher, prong, holding bar, balloon, jaws, combinations thereof, or the like. The crimping devices may also include or comprise a holding structure to hold the self-expanding device in an unexpanded or expanded configuration.

摘要翻译： 这里描述了用于卷曲自扩张装置的装置和方法。 卷曲装置可用于卷曲各种不同的自扩张装置（无论这种装置是可生物降解的还是生物耐久的）。 压接装置可以具有压接构件以接合自膨胀装置，以将装置从扩张构型减小到未膨胀构型。 压接构件可以包括或包括缝合线，线，带，引导环，推动器，插脚，保持杆，气球，钳口，其组合等。 压接装置还可以包括或包括用于将自膨胀装置保持在未膨胀或膨胀构型的保持结构。

公开(公告)号：US08658081B2

公开(公告)日：2014-02-25

申请号：US12845536

申请日：2010-07-28

申请人： David C. Gale ,  Bin Huang ,  Timothy Limon ,  Vincent J. Gueriguian

发明人： David C. Gale ,  Bin Huang ,  Timothy Limon ,  Vincent J. Gueriguian

IPC分类号： B29C49/08

CPC分类号： A61F2/915 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91583 ,  A61F2002/9522 ,  A61F2210/0004 ,  A61F2220/0016 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  B29C35/045 ,  B29C49/0005 ,  B29C49/14 ,  B29C49/4273 ,  B29C49/4823 ,  B29C55/22 ,  B29C55/24 ,  B29C69/001 ,  B29C2049/0089 ,  B29C2793/0009 ,  B29K2067/00 ,  B29K2067/046 ,  B29K2105/258 ,  B29K2995/006 ,  B29L2031/7534 ,  Y10T156/1026 ,  C08L67/04

摘要： Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.

摘要翻译： 公开了制造具有增强的断裂韧性的支架的支架和方法。

公开(公告)号：US08585731B2

公开(公告)日：2013-11-19

申请号：US12334382

申请日：2008-12-12

申请人： Anthony J. Abbate ,  Bin Huang ,  Gail M. Zaler ,  David C. Gale ,  Richard E. Kaufman

发明人： Anthony J. Abbate ,  Bin Huang ,  Gail M. Zaler ,  David C. Gale ,  Richard E. Kaufman

IPC分类号： A61M29/00 ,  A61M31/00

CPC分类号： A61L31/022 ,  A61B17/24 ,  A61B17/3468 ,  A61B17/3478 ,  A61B2017/3454 ,  A61F2/04 ,  A61F2/18 ,  A61F2/186 ,  A61F2/82 ,  A61F2/86 ,  A61F2/89 ,  A61F2/95 ,  A61F5/08 ,  A61F2002/048 ,  A61F2002/91508 ,  A61F2002/9522 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0091 ,  A61F2240/001 ,  A61F2250/003 ,  A61F2250/006 ,  A61F2250/0067 ,  A61K9/70 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61M29/00

摘要： Described here are self-expanding devices and methods of using and making them. The devices may be useful in a variety of locations within the body, for a number of different uses. In some variations, the devices have a first compressed configuration enabling low profile delivery through a delivery device, a second expanded configuration for apposition against tissue, and comprise either a single continuous filament or at least two non-intersecting filaments. In some variations, the device is formed into a shape having a series of peaks and valleys. At least one of the peaks and valleys may have a loop at then end thereof. At least a portion of these devices may be capable of biodegrading over a predetermined period of time, and the devices may be configured for drug delivery. Methods of treating one or more sinus cavities are also described here.

公开(公告)号：US08496615B2

公开(公告)日：2013-07-30

申请号：US13446761

申请日：2012-04-13

申请人： Paul M. Consigny ,  Fozan O. El-Nounou ,  David C. Gale ,  Pamela A. Kramer-Brown

发明人： Paul M. Consigny ,  Fozan O. El-Nounou ,  David C. Gale ,  Pamela A. Kramer-Brown

IPC分类号： A61M29/00

CPC分类号： A61M25/10 ,  A61F2/013 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/40 ,  A61L2300/432 ,  A61L2300/62 ,  A61L2430/26 ,  A61M25/04 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2025/105

摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.