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    Delivery of Biologic Therapeutics
    61.
    发明申请
    Delivery of Biologic Therapeutics 有权
    交付生物治疗

    公开(公告)号：US20140186446A1

    公开(公告)日：2014-07-03

    申请号：US14142651

    申请日：2013-12-27

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Mikael Trollsas ,  John Stankus ,  James Su ,  Syed Hossainy ,  Joshua Takeshi Smith ,  Shadid Askar

    IPC: A61K9/14 ,  A61K38/19 ,  A61K38/21 ,  C07K16/18

    CPC classification number: A61K9/146 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/08 ,  A61K38/215 ,  A61K47/10 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/40 ,  C07K2317/21

    Abstract: Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.

    Abstract translation: 公开了提供对体内空间的生物治疗剂的受控的持续释放的制剂和方法。 更具体地，公开了包含多个亲水性聚合物链的制剂，以及形成和施用这些制剂的方法。 在一些实施方案中，制剂在生物治疗的三十至九十天内显示爆发释放，初始释放，三相释放和释放。 在一些实施方案中，制剂将生物治疗剂的可逆沉淀显示为具有约50nm至约10μm直径的沉淀物。

    DRUG COATED BALLOON CATHETER AND PHARMACOKINETIC PROFILE
    63.
    发明申请
    DRUG COATED BALLOON CATHETER AND PHARMACOKINETIC PROFILE 审中-公开
    药物涂层气囊导管和药物动力学特征

    公开(公告)号：US20140046254A1

    公开(公告)日：2014-02-13

    申请号：US14054797

    申请日：2013-10-15

    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

    Inventor： John Stankus ,  Mikael Trollsas ,  Syed Hossainy ,  Zhang Liangxuan ,  Ed Berger ,  Stephen Pacetti ,  John L. Toner

    IPC: A61L29/16 ,  A61L29/08

    CPC classification number: A61L29/16 ,  A61L29/08 ,  A61L29/085 ,  A61L29/141 ,  A61L2300/416 ,  A61L2300/606

    Abstract: A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.

    Abstract translation: 提供了药物递送球囊，其包括具有表面的球囊，以及设置在球囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂，赋形剂和增塑剂。 根据本主题，至少30％的涂层在气球膨胀后两分钟内从气球表面转移。 或者，至少30％的涂层在充气后一分钟内从气球表面转移。 涂层导致脉管系统或靶组织中细胞抑制治疗剂的有效药代动力学特征。

    SURFACE MODIFICATION OF MEDICAL DEVICES TO ENHANCE ENDOTHELIAL ADHESION AND COVERAGE
    66.
    发明申请
    SURFACE MODIFICATION OF MEDICAL DEVICES TO ENHANCE ENDOTHELIAL ADHESION AND COVERAGE 审中-公开
    医疗器械的表面改性，以增强内皮粘连和覆盖

    公开(公告)号：US20130103138A1

    公开(公告)日：2013-04-25

    申请号：US13655762

    申请日：2012-10-19

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Syed Hossainy ,  Mikael Trollsas ,  Kristen O'Halloran Cardinal ,  Marcus Foley ,  Paul Consigny

    IPC: A61F2/82 ,  B05D5/00

    CPC classification number: A61L31/043 ,  A61F2/0077 ,  A61F2/07 ,  A61F2/91 ,  A61L31/10 ,  A61L2400/18

    Abstract: Acceleration of the endothelialization process on implantable medical devices having at least one blood-contacting surface is achieved by a microscale pattern of sub-sections of EC-inductive coatings or EC-conductive coatings and nano/macro textured surfaces. The EC-inductive coating and EC-conductive coating can be applied either on the entire surface of the blood-contacting surface or selective placed on the blood-contacting surface, for example, in particular patterns. In this regard, the EC-conductive and EC-inductive coatings can be selectively placed relative to the textured surface to achieve a desired pattern of texture surface to coatings.

    Abstract translation: 具有至少一个血液接触表面的可植入医疗装置上的内皮化过程的加速通过EC感应涂层或EC-导电涂层和纳米/宏纹理表面的细分图形来实现。 EC感应涂层和EC-导电涂层可以施用在接触血液的表面的整个表面上，或者被选择性地施加在接触血液的表面上，例如特别是图案。 在这方面，EC导电和EC感应涂层可以相对于纹理表面选择性地放置，以获得所需的纹理表面与涂层的图案。

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