公开(公告)号：US20220126262A1

公开(公告)日：2022-04-28

申请号：US17424996

申请日：2020-01-22

Applicant: INSTITUTE FOR BASIC SCIENCE ,  UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Cybulski OLGIERD ,  Dygas MIROSLAW ,  Mikulak-klucznik BARBARA ,  Sobolev YAROSLAV ,  Grzybowski BARTOSZ A

IPC: B01J19/28 ,  B01J19/00

Abstract: The present invention relates to a reaction method for forming a layered structure of immiscible liquid-phase concentric layers within a rotary reactor and a reaction system including the layered structure, and may provide a basis capable of efficiently performing a multistage reaction in terms of time and space.

公开(公告)号：US11236343B2

公开(公告)日：2022-02-01

申请号：US16346251

申请日：2017-11-01

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Won Jong Kim ,  Jeong Hun Kim ,  Jihyun Lee ,  Byung Joo Lee

IPC: C12N15/115 ,  A61K47/61 ,  A61P27/02 ,  A61P35/00 ,  A61K31/713

Abstract: The present invention relates to a method for producing dextran polymer-based amplified nucleic acid aptamer nanoconstructs which efficiently and selectively capture a specific target molecule, the method comprising linking a short nucleic acid sequence or a complementary sequence for formation of nanoconstructs and a nucleic acid aptamer sequence for capture of the specific target molecule to a dextran polymer by a chemical reaction, mixing the resulting polymer/nucleic acid substances with each other to form nanostructures, subjecting the nanostructures to rolling circle amplification, thereby forming a nucleic acid aptamer having a repeated structure. The dextran polymer-based amplified nucleic acid aptamer nanoconstructs have the effect of efficiently and selectively capturing a specific target molecule.

公开(公告)号：US20220019846A1

公开(公告)日：2022-01-20

申请号：US17375650

申请日：2021-07-14

Applicant: Institute for Basic Science

Inventor： Meeyoung CHA ,  Sungwon HAN ,  Sungwon PARK ,  Sundong KIM ,  Sungkyu PARK

IPC: G06K9/62 ,  G06K9/42

Abstract: Disclosed is an image analysis system which includes a first analyzer and a second analyzer. The first analyzer generates first features by encoding images through a first model and adjusts a weight of the first model based on the first features. The second analyzer generates second features based on the first features by encoding the images through a second model, classifies the second features into classes, respectively, and adjusts a weight of the second model based on mutual information and a correlation between a first class among the classes which features corresponding to an original image group from among the second features are classified as and a second class among the classes which features corresponding to an augmentation group of the original image group from among the second features are classified as.

公开(公告)号：US11197935B2

公开(公告)日：2021-12-14

申请号：US15807850

申请日：2017-11-09

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Dong Wook Kim ,  Jin Soo Kim ,  Chul Yong Park ,  Duk Hyoung Kim ,  Jung Eun Kim ,  Jiyeon Kweon

IPC: A61K48/00 ,  C12N5/074 ,  C12N9/22 ,  C12N15/11 ,  A61K35/545 ,  C07K14/755 ,  C12N15/113 ,  A61K35/12

Abstract: The present invention provides a method for inducing an inversion of normal blood coagulation factor VIII (F8) gene, a method for correcting an inversion of blood coagulation factor VIII gene in which the inversion has occurred, and a Hemophilia A patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the F8 gene, which is responsible for the majority of severe hemophilia A, and thereby may be effectively used for studying the development mechanism of hemophilia A and as a research tool for screening therapeutic agents. The inversion-corrected induced pluripotent stem cell constructed according the method of the present invention enables an efficient and fundamental treatment for hemophilia A by restoring a genotype in which mutation has occurred to a wild type-like state, without limitation via normal gene or protein delivery.

公开(公告)号：US11155604B2

公开(公告)日：2021-10-26

申请号：US15742874

申请日：2016-12-21

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Won Do Heo ,  Yun Ju Lee ,  Daseuli Yu ,  Byung Ouk Park

IPC: C07K16/00 ,  C07K14/00 ,  C07K16/14 ,  C07K16/18

Abstract: The present invention relates to the preparation of an antibody analogue capable of being activated reversibly, and uses thereof, and provides a fusion protein comprising an inactive first fragment of an antibody analogue is fused to a stimulus-induced dimerization protein.

公开(公告)号：US20210254161A1

公开(公告)日：2021-08-19

申请号：US17181142

申请日：2021-02-22

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE ,  ANLBIO

Inventor： Kee Tae KIM ,  Hong Gil NAM ,  Chand Parvez DANKA MOHAMMED

IPC: C12Q1/6883 ,  C12N15/113 ,  G01N33/50 ,  G01N33/68

Abstract: Provided are a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions.

公开(公告)号：US20210152348A1

公开(公告)日：2021-05-20

申请号：US16845601

申请日：2020-04-10

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Kyung Ah SHIM ,  Hyun Suk MOON

IPC: H04L9/08 ,  H04L9/30 ,  G06F17/11

Abstract: A method of generating a public key and a secret key using a key generator is disclosed. The method includes acquiring an affine map and a secret central map, and generating a public key and a secret key using the affine map and the secret central map, in which the secret central map is expressed as a system of o multivariate quadratic polynomials, the system of o multivariate quadratic polynomials can be expressed as a structured matrix or a product of a submatrix of a structured matrix and a vector when v linear equations and v variables defined on a finite field are given.

公开(公告)号：US10858662B2

公开(公告)日：2020-12-08

申请号：US15527837

申请日：2015-11-19

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin Soo Kim ,  Tae Young Koo

IPC: C12N15/74 ,  C12N15/63 ,  C12N15/11 ,  C12N15/864 ,  C12N15/867 ,  C12N9/16 ,  C12N9/22

Abstract: The present invention relates to a method for regulating gene expression, comprising introducing into a cell each of a recombinant vector which expresses a first domain comprising N-terminus of a Cas9 protein, and a recombinant vector which expresses a second domain comprising C-terminus of a Cas9 protein, a composition comprising the recombinant vectors, a kit for regulating gene expression, and a method for intracellular production of Cas9 protein. Moreover, the present invention relates to a transformed cell introduced with a viral vector which packages the first domain, and a viral vector which packages the second domain, and to a composition comprising a virus produced therefrom.

公开(公告)号：US20200318193A1

公开(公告)日：2020-10-08

申请号：US16889372

申请日：2020-06-01

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Kee Tae KIM ,  Hong Gil Nam ,  Chand Parvez Danka Mohammed

IPC: C12Q1/6883 ,  C12N15/113 ,  G01N33/50 ,  G01N33/68

Abstract: The present invention relates to a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions. The present invention confirms that miR-204, among miRNAs up-regulated in an aged hippocampus, decreases the expression of EphB2, by accurately targeting EphB2, which is an important regulatory receptor, resulting in a decrease in the neuronal surface expression of an NR1 subunit of an NMDAR in hippocampal nerves and a decrease in the density of dendrites, thereby having an effect of determining whether the functions of the hippocampus are decreased, by using the correlation between a miRNA and an NMDAR, and furthermore, has an effect of providing a method for inhibiting the decrease in the functions of the hippocampus, and a method for screening for inhibitors of the decrease in the functions.

公开(公告)号：US10543477B2

公开(公告)日：2020-01-28

申请号：US15586068

申请日：2017-05-03

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Kimoon Kim ,  Gyeongwon Yun ,  Zahid Hassan ,  Jiyeong Lee ,  Jeehong Kim ,  Nam Hoon Kim ,  Kangkyun Baek ,  Ilha Hwang

IPC: B01J23/52 ,  B01J31/06 ,  C08J7/06 ,  C08J7/12 ,  B01J23/44 ,  B01J23/42 ,  B01J35/00 ,  B01J13/18 ,  B01J33/00 ,  B82Y30/00 ,  B01J35/02 ,  B01J37/02 ,  B01J37/16

Abstract: Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b).