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公开(公告)号：US20160139126A9
公开(公告)日：2016-05-19
申请号：US14391085
申请日：2013-03-15
Applicant: Fundació Institut de Recerca Biomèdica (IRB Barcelona) , Institució Catalana de Recerca i Estudis Avançats
Inventor： Roger Gomis , Milica Pavlovic , Evarist Planet , Anna Arnal , Maria Tarragona
IPC: G01N33/574 , C12Q1/68 , C07K16/28
CPC classification number: G01N33/5748 , C07K16/2875 , C07K2317/21 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57407 , G01N33/57415 , G01N2333/4706
Abstract: The present invention relates to a method for the prognosis of bone metastasis in triple negative (including basal-like) breast cancer or, alternatively, ER+ breast cancer (including luminal A and B) which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of triple negative (including basal-like) breast cancer metastasis or, alternatively, ER+ breast cancer (including luminal A and B) metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering breast cancer and for classifying a subject from breast cancer into a cohort.
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公开(公告)号：US20150289795A1
公开(公告)日：2015-10-15
申请号：US14442015
申请日：2013-11-12
Applicant: INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS , FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA)
Inventor： Eduard Batlle Gómez , Elena Sancho Suils , David Rossell Ribera , Alexandre Calon , Elisa Espinet Hernández , Sergio Palomo Ponce
CPC classification number: A61B5/4255 , A61B5/15 , A61B5/4839 , A61B10/02 , A61K31/4709 , A61N5/10 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/3481 , G16H50/50
Abstract: The invention relates to methods for predicting the risk of relapse of cancer patients as well as methods for providing personalized medicine to said patients based on the expression levels of different genes the expression of which is induced in response to TGF-beta stimulation. The invention also relates to kits for carrying out the diagnostic and predictive medicine methods.
Abstract translation: 本发明涉及用于预测癌症患者复发风险的方法以及根据TGF-β刺激诱导其表达的不同基因的表达水平向所述患者提供个性化药物的方法。 本发明还涉及用于实施诊断和预测药物方法的试剂盒。
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公开(公告)号：US12196758B2
公开(公告)日：2025-01-14
申请号：US17108390
申请日：2020-12-01
Applicant: Fundació Institut de Recerca Biomedica (IRB Barcelona) , Institució Catalana de Recerca I Estudis Avançats
Inventor： Roger Gomis , Milica Pavlovic , Evarist Planet , Anna Arnal , Maria Tarragona
IPC: C12Q1/6886 , C07K16/28 , G01N33/574
Abstract: The present invention relates to a method for the prognosis of bone metastasis in triple negative (including basal-like) breast cancer or, alternatively, ER+ breast cancer (including luminal A and B) which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of triple negative (including basal-like) breast cancer metastasis or, alternatively, ER+ breast cancer (including luminal A and B) metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering breast cancer and for classifying a subject from breast cancer into a cohort.
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公开(公告)号：US12181541B2
公开(公告)日：2024-12-31
申请号：US18110638
申请日：2023-02-16
Applicant: FUNDACIÓ INSTITUT DE CIENCIES FOTONIQUES , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS , Politecnico Di Milano , Consiglio Nazionale Delle Ricerche
Inventor： Morgan Mitchell , Vito Giovanni Lucivero , Roberto Osellame , Giacomo Corrielli , Andrea Zanoni
Abstract: Provided is an atomic vapor cell, for atomic or molecular spectroscopy, optical pumping, and/or spin-based atomic sensing, that includes a host substrate and defined there within a buried or non-buried chamber laser written in the host substrate without the need of a mask or photoresist, with either planar or three-dimensional geometry, and intended to contain an atomic vapor.
Also provided are an integrated atomic/photonic device and an apparatus, in both cases including the presently disclosed atomic vapor cell, and a method for fabricating the presently disclosed atomic vapor cell.-
公开(公告)号：US20240382537A1
公开(公告)日：2024-11-21
申请号：US18693284
申请日：2022-09-20
Applicant: Pulmobiotics, S.L. , Fundació Centre De Regulació Genòmica , Institució Catalana De Recerca I Estudis Avançats
Inventor： Rocco Mazzolini , Maria Lluch Senar , Claudio Joao Ribeiro Dos Santos , Luis Serrano Pubul
Abstract: The present invention concerns genetically modified Mycoplasma bacteria that express gene products having an anti-biofilm activity against a biofilm formed by multiple bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus. Further intended are pharmaceutical compositions comprising genetically modified Mycoplasma bacteria and their use as a medicament.
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Patent Agency Ranking
公开(公告)号：US20240268740A1
公开(公告)日：2024-08-15
申请号：US18566540
申请日：2022-05-31
Applicant: INBRAIN NEUROELECTRONICS SL , FUNDACIÓ INSTITUT CATALÀ DE NANOCIÈNCIA I NANOTECNOLOGIA (ICN2) , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA)
Inventor： Damià VIANA , José GARRIDO , Steven WALTSON
CPC classification number: A61B5/263 , A61N1/0534 , A61N1/0551 , C25B3/07 , A61B2562/125
Abstract: The present invention relates to a reduced graphene oxide structure for stimulation and/or recording of the central and/or peripheral nervous system comprising a stack of layered. reduced graphene oxide flakes, wherein the reduced graphene oxide structure is electrochemically activated.
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公开(公告)号：US20240255502A9
公开(公告)日：2024-08-01
申请号：US17818802
申请日：2022-08-10
Applicant: FUNDACIÓ DE RECERCA CLÍNIC BARCELONA-INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER , Institució Catalana de Recerca i Estudis Avançats (ICREA)
Inventor： Josep Dalmau , Lidia Sabater , Francesc Graus
IPC: G01N33/564 , G01N33/68
CPC classification number: G01N33/564 , G01N33/6854
Abstract: A method involves detecting in a sample an autoantibody binding specifically to one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2. An autoantibody binds specifically to one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2. A diagnostically useful carrier with a solid phase with an immobilized polypeptide contains one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2 or a variant thereof. The autoantibody can be used for diagnosing a neurological autoimmune disease or a cancer.
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公开(公告)号：US20240208998A1
公开(公告)日：2024-06-27
申请号：US18556456
申请日：2022-04-21
Applicant: FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLÓGICA DE VALL HEBRON , UNIVERSITAT DE BARCELONA , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
Inventor： Héctor GARCÍA PALMER , Isabel PUIG BORREIL , Josep TABERNERO CATURLA , Carlos GALDEANO CANTADOR , Diego MUÑOZ-TORRERO LÓPEZ-IBARRA , Xavier BARRIL ALONSO , Sergio RUIZ CARMONA
IPC: C07D513/04 , A61K31/427 , A61K31/429 , A61P35/00 , C07D417/14 , C07D519/00
CPC classification number: C07D513/04 , A61K31/427 , A61K31/429 , A61P35/00 , C07D417/14 , C07D519/00
Abstract: The present invention relates to 2-aminothiazol or 2-aminooxazol derivatives or pharmaceutically acceptable salt thereof for use in the treatment of hyperproliferative disorders, to method of treatment and/or prevention of hyperproliferative disorders using said compounds and to a subgroup of said derivatives which are new.
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公开(公告)号：US12006221B2
公开(公告)日：2024-06-11
申请号：US17546488
申请日：2021-12-09
Applicant: CORNING INCORPORATED , Fundació Institut de Ciències Fotòniques (ICFO) , Institució Catalana de Recerca i Estudis Avançats
Inventor： Therese Francoise Arliguie , Theresa Chang , Miriam Marchena Martin-Francés , Prantik Mazumder , Valerio Pruneri , Frederic Christian Wagner
IPC: C01B32/194 , B05D1/00 , B05D3/12
CPC classification number: C01B32/194 , B05D1/005 , B05D3/12 , B05D2350/60 , B05D2505/50 , C01B2204/22
Abstract: A method of forming a functionalized device substrate is provided that includes the steps of: forming a conductive layer on a growth substrate; applying a polymeric layer to a device substrate, wherein a coupling agent couples the polymeric layer to the device substrate; coupling the polymeric layer to the conductive layer on the growth substrate; and peeling the growth substrate from the conductive layer.
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公开(公告)号：US11860502B2
公开(公告)日：2024-01-02
申请号：US17113749
申请日：2020-12-07
Applicant: FUNDACIÓ INSTITUT DE CIÈNCIES FOTÒNIQUES , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
Inventor： Frank Koppens , Bernat Terrés , Hitesh Agarwal
CPC classification number: G02F1/2257 , G02F1/212 , G02F2202/42
Abstract: Provided is an electro-optical modulator, particularly a double layer graphene modulator having an optimized arrangement to provide both a large optical bandwidth and a high optical transmission for light travelling through an optical waveguide of the modulator, wherein at least one of a top and a bottom graphene sheets extends along a X-direction:
above part of the width of the optical waveguide, wherein that part ranges from 50% to 100% of the width of the optical waveguide; or
completely above the whole width of the optical waveguide, and beyond through a respective further projecting portion with a length, along the X direction, of up to 25% of the optical waveguide width.
Provided is also a method for obtaining the electro-optical modulator of the invention.
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