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    Amine compounds, their production and use
    55.
    发明申请
    Amine compounds, their production and use 有权
    胺化合物，其生产和使用

    公开(公告)号：US20020032189A1

    公开(公告)日：2002-03-14

    申请号：US09931140

    申请日：2001-08-16

    发明人： Kaneyoshi Kato ,  Jun Terauchi ,  Hiroaki Fukumoto ,  Mitsuru Kakihana

    IPC分类号： A61K031/55 ,  A61K031/445 ,  A61K031/40 ,  C07D207/46 ,  A61K031/135

    CPC分类号： C07D213/30 ,  C07B2200/07 ,  C07C217/74 ,  C07C255/54 ,  C07C2602/10 ,  C07D215/14 ,  C07D215/20 ,  C07D215/58 ,  C07D271/06 ,  C07D277/64 ,  C07D295/096 ,  C07D307/80 ,  C07D317/54 ,  C07D333/16

    摘要： A compound of the formula: 1 wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) nullSnull, nullSOnull or nullSO2null, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) nullCOnullOnull or (v) null(CH2)p-X1-, null(CH2)p-X1-(CH2)q-, null(CH2)r-CO-X1-, nullSO2nullNR8- or null(CH2)r-SO2nullNR8- wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, pnullq is 1 to 5, and r is 1 to 4; Y is a divalent C1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1 and R2 each is H or a lower alkyl which may be substituted, or R1 and R2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-null protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.

    摘要翻译： 下式的化合物：其中Ar是可被取代的芳环组合基团或可被取代的稠合芳基; X是（i）键，（ii）-S-，-SO-或-SO 2 - ，（iii）C 1-6亚烷基，C 2-6亚烯基或C 2-6亚炔基等，（iv）-CO- O-或（V） - （CH 2）p -X 1 - ， - （CH 2）p -X 1 - （CH 2）q - ， - （CH 2）r -CO-X 1 - ，-SO 2 -NR 8 - 或 - （CH 2） r-SO 2 -NR 8 - ，其中X 1为O或NR 8，R 8为H，可被取代的烃基或酰基，p为0至5，q为1至5，p + q为1至5，r 是1到4; Y是任选地含有O或S的二价C 1-6脂族烃基，其可被取代; R 1和R 2各自为H或可被取代的低级烷基，或R 1和R 2形成可被取代的含氮杂环; 环A是可以被进一步取代的苯环; 环B为可进一步取代的4-至8-元环，或其盐具有抑制淀粉样蛋白β蛋白产生和/或分泌的作用，并且可用作预防和/或治疗 神经变性疾病等

    1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents
    57.
    发明授权
    1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents 失效
    1-氨基（或取代的氨基）-1,4-二氢-4-氧代-6-氟-7-杂环喹啉-3-羧酸及其作为抗菌剂的用途

    公开(公告)号：US4499091A

    公开(公告)日：1985-02-12

    申请号：US466095

    申请日：1983-02-14

    申请人： Mark P. Wentland ,  Denis M. Bailey

    发明人： Mark P. Wentland ,  Denis M. Bailey

    IPC分类号： C07D215/58 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  A61K31/47

    CPC分类号： C07D401/04 ,  C07D215/58

    摘要： Novel 1-R-1,4-dihydro-4-oxo-6-fluoro-7-(Z.dbd.N--)-quinolinecarboxylic acids and esters thereof, where R is amino, lower-alkylamino, 2-propenylamino or di-lower-alkylamino, R" is hydrogen or lower-alkyl, and Z.dbd.N is a heterocyclic group, useful as antibacterial agents, are prepared by reacting the corresponding 7-chloroquinoline derivatives with the appropriate heterocyclic compound, Z.dbd.NH. A preferred group of compounds are those where Z.dbd.N is 1-piperazinyl or 4-lower-alkyl-1-piperazinyl.

    摘要翻译： 新的1-R-1,4-二氢-4-氧代-6-氟-7-（Z = N - ） - 喹啉羧酸及其酯，其中R是氨基，低级烷基氨基，2-丙烯基氨基或二低级 - 烷基氨基，R“是氢或低级烷基，Z = N是可用作抗菌剂的杂环基团，通过使相应的7-氯喹啉衍生物与适当的杂环化合物Z = NH反应来制备。 一组优选的化合物是其中Z = N是1-哌嗪基或4-低级 - 烷基-1-哌嗪基的化合物。